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  • 1
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2010
    In:  European Journal of Echocardiography Vol. 11, No. Supplement 2 ( 2010-12-07), p. ii158-ii186
    In: European Journal of Echocardiography, Oxford University Press (OUP), Vol. 11, No. Supplement 2 ( 2010-12-07), p. ii158-ii186
    Type of Medium: Online Resource
    ISSN: 1525-2167 , 1532-2114
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2010
    detail.hit.zdb_id: 2042482-6
    detail.hit.zdb_id: 2647943-6
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  • 2
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Cell and Developmental Biology Vol. 10 ( 2023-1-10)
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 10 ( 2023-1-10)
    Abstract: Introduction: The centrally projecting Edinger-Westphal nucleus (EWcp) contributes to the control of alcohol consumption by its urocortin 1 (UCN1) and cocaine- and amphetamine-regulated transcript (CART) co-expressing peptidergic neurons. Our group recently showed that the urocortinergic centrally projecting EWcp is the primary seat of central nervous system transient receptor potential ankyrin 1 (TRPA1) cation channel mRNA expression. Here, we hypothesized that alcohol and its metabolites, that pass through the blood-brain barrier, may influence the function of urocortinergic cells in centrally projecting EWcp by activating TRPA1 ion channels. We aimed to examine the functional activity of TRPA1 in centrally projecting EWcp and its possible role in a mouse model of acute alcohol exposure. Methods: Electrophysiological measurements were performed on acute brain slices of C57BL/6J male mice containing the centrally projecting EWcp to prove the functional activity of TRPA1 using a selective, potent, covalent agonist JT010. Male TRPA1 knockout (KO) and wildtype (WT) mice were compared with each other in the morphological studies upon acute alcohol treatment. In both genotypes, half of the animals was treated intraperitoneally with 1 g/kg 6% ethanol vs. physiological saline-injected controls. Transcardial perfusion was performed 2 h after the treatment. In the centrally projecting EWcp area, FOS immunohistochemistry was performed to assess neuronal activation. TRPA1, CART, and urocortin 1 mRNA expression as well as urocortin 1 and CART peptide content was semi-quantified by RNAscope in situ hybridization combined with immunofluorescence. Results: JT010 activated TRPA1 channels of the urocortinergic cells in acute brain slices. Alcohol treatment resulted in a significant FOS activation in both genotypes. Alcohol decreased the Trpa1 mRNA expression in WT mice. The assessment of urocortin 1 peptide immunoreactivity revealed lower basal urocortin 1 in KO mice compared to WTs. The urocortin 1 peptide content was affected genotype-dependently by alcohol: the peptide content decreased in WTs while it increased in KO mice. Alcohol exposure influenced neither CART and urocortin 1 mRNA expression nor the centrally projecting EWcp/CART peptide content. Conclusion: We proved the presence of functional TRPA1 receptors on urocortin 1 neurons of the centrally projecting EWcp. Decreased Trpa1 mRNA expression upon acute alcohol treatment, associated with reduced neuronal urocortin 1 peptide content suggesting that this cation channel may contribute to the regulation of the urocortin 1 release.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2737824-X
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  • 3
    In: Mentálhigiéné és Pszichoszomatika, Akademiai Kiado Zrt., Vol. 22, No. 1 ( 2021-04-24), p. 1-49
    Abstract: Elméleti háttér: Fogyasztói kultúránkat jelentős mértékben meghatározza, hogy az emberi testnek központi szerepet tulajdonít. Ezen túlmenően a fiatalságot és szépséget tekinti az ideális és kívánt állapotnak. A női test kitüntetett helyet foglal el ebben a rendszerben. A fehérneműreklámokban jellemzően egysíkú nőábrázolással találkozhatunk, amely figyelmen kívül hagyja a fogyasztók életkori heterogenitását, eltérő életciklusát, testalkatát és igényeit. Azt, hogy kire milyen módon hatnak a reklámok, számos tényező befolyásolja. Cél: A 20 és 65 év közötti nők fehérneműreklámokhoz fűződő asszociációinak vizsgálata, továbbá annak körüljárása, hogy a fehérneműmodellek megítélése hogyan függ össze a nők saját testükkel kapcsolatos elégedettségével. Módszer: A feltáró kutatásban 95 nő (átlagéletkor: 40,9 [SD = 12,6] év) vett részt, a népességi adatoknak megfelelő korosztályi arányban. A papír-ceruza teszteken túl a résztvevőkkel készült fehérneműreklámokról szóló interjúkat és reklámképekre adott reakcióikat tartalomelemzéses módszerrel értékeltük. Eszközök: Emberalakrajzok Tesztje, Sziluett-teszt, Képasszociációs feladat, Szituációs feladat, gondolattérkép készítése. Eredmények: A nők 66,3%-a utalt rá, hogy az átlagos nőktől eltérőek a fehérneműreklámokban szereplő modellek. Jelentős együttjárás van abban, hogy milyen testalkatot tartanak a nők ideálisnak saját maguk és a fehérneműmodellek számára ( r = 0,56; p 〈 0,001). A testtömegindex bejósló hatású ( ß = –0,16; p 〈 0,001) a saját testtel (centrális területtel) való elégedettségre. A legtöbben (59%) a bokájukkal voltak elégedettek, míg a legnagyobb számban (37%-ban) a csípőjükkel kapcsolatban fejezték ki elégedetlenségüket. A megkérdezett nők 53,7%-a fejezte ki aktuális testalkatával való elégedettségétől, életkorától, iskolázottságától függetlenül, hogy változatosabb testalkatú nők megjelenítésére vágyik a fehérneműreklámokban. Jelentős arányban (41,1%) jelent meg a változatosabb életkorú modellek megjelenítésére való igény is. A modell testalkatának változására vonatkozó igényt előre jelzi a diszkrepancia élményének kifejezése (OR = 1,95; p = 0,003), a modell életkorának változására vonatkozó igény mértéke, továbbá bejósolható a válaszadó életkora (OR = 1,05; p = 0,008), illetve a diszkrepancia említésének gyakorisága alapján (OR = 1,71; p = 0,009). A modell változatosabb testalkata iránti igény jelentősen összefügg a modell életkorának változását sürgető válaszokkal ( r s = 0,58; p 〈 0,001). Következtetés: A nők jelentős százaléka szóvá teszi, hogy különbséget lát a modellek és a hétköznapi nők testalkata között. A résztvevők nagyobb része nem tartja ideálisnak jelenlegi testalkatát. Többen voltak teljesen elégedettek a „perifériás” testrészeikkel, mint a „centrális” területekkel. A modellek és a hétköznapi nők ideális testalkatának együttjárása utalhat arra is, hogy a modellek által megjelenített testideál fontos a nők saját ideális testalkatának meghatározásában, de az is lehetséges, hogy a nők testalkat tekintetében magukhoz hasonló modelleket szeretnének viszontlátni a reklámokban. A résztvevők jelentős része kifejezte igényét a reklámokban megjelenő fehérneműmodellek változatosabb megjelenítésére mind a testalkatot, mind az életkort tekintve, ami a fehérneműreklámokban megjelenített nőkép újragondolásának igényére hívja fel a figyelmet, különös tekintettel az ideáltól való eltérés esetleges negatív pszichés következményeire. Background: Our consumer culture is largely defined by the central role it attributes to the human body. Moreover, it views youth and beauty as the ideal and desirable state. Female bodies play a prominent role in this system. Representation of women in lingerie advertisements typically ignores the heterogeneous ages, life stages, body types, and needs of women. How individuals are affected by advertising is influenced by multiple factors. Purpose: Examining the associations of women between the ages of 20 and 65 on lingerie advertisements, and exploring the interaction between the judgement of lingerie models, and women’s body satisfaction. Methods: The pilot study had 95 female participants (mean age: 40.9 [SD = 12.6] years) whose ages reflect a similar age distribution to that of the broader population of Hungary. In addition to analysis of questionnaires, content analysis was applied to interviews and reactions to advertisements. Measures: Fallon-Rozin body shape figure scale (1985), Silhouette-test, Picture association exercise, Situational exercise, Mind Map. Results: 66.3% of women indicated that models featured in lingerie advertisements do not reflect average women. The body size that women saw as ideal for themselves and for lingerie models correlate significantly ( r = 0.56, p 〈 0.001). Body mass index is predictive ( ß = –0.16, p 〈 0.001) of satisfaction with the central areas of the body. Most participants were satisfied with their ankle (59%), and dissatisfaction with hips was most common (37%). 53.7% of participants expressed a desire to have more diverse body types featured in lingerie advertisements. This is independent of their current body satisfaction, body mass index, age or level of education. A significant amount (41.1%) of participants expressed their demand for more diversity in the age of models as well. The frequency of mentioning the demand for changing the body type of models can be predicted based on the expression of discrepancy (OR = 1.95; p = 0.003), and the extent of the demand for changing the age of models can be predicted based on the age of the participant (OR = 1.05, p = 0.008) and the frequency of referring to the discrepancy between models and other women (OR = 1.71, p = 0.009). The demand for more diverse body types strongly correlate with the responses demanding a change of the age of lingerie models ( r s = 0.58, p 〈 0.001). Discussion: A considerable percentage of women point out perceiving a difference between the body types of models and everyday women. Most participants do not regard their current body type as ideal. More women were satisfied with their ‘peripheral’ than their ‘central’ areas. The correlation between the ideal body type that women identify for themselves and for models may indicate that the body ideal represented by models is important in defining women’s body ideals, but it is also possible that women are expressing a wish to see models that are more similar to themselves. A significant number of women expressed a need for more diversity among lingerie models regarding both body type and age, which highlights a need to reconsider the image of women represented in lingerie advertising, especially considering the potential adverse psychological effects of differing from the ideal.
    Type of Medium: Online Resource
    ISSN: 1419-8126 , 1786-3759
    Language: Unknown
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2021
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  • 4
    In: Journal of Investigative Dermatology, Elsevier BV, Vol. 138, No. 8 ( 2018-08), p. 1774-1784
    Type of Medium: Online Resource
    ISSN: 0022-202X
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2006902-9
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  • 5
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Physiology Vol. 14 ( 2023-6-7)
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 14 ( 2023-6-7)
    Abstract: Introduction: Previous studies have established that endogenous inorganic polysulfides have significant biological actions activating the Transient Receptor Potential Ankyrin 1 (TRPA1) receptor. Organic polysulfides exert similar effects, but they are much more stable molecules, therefore these compounds are more suitable as drugs. In this study, we aimed to better understand the mechanism of action of organic polysulfides by identification of their binding site on the TRPA1 receptor. Methods: Polysulfides can readily interact with the thiol side chain of the cysteine residues of the protein. To investigate their role in the TRPA1 activation, we replaced several cysteine residues by alanine via site-directed mutagenesis. We searched for TRPA1 mutant variants with decreased or lost activating effect of the polysulfides, but with other functions remaining intact (such as the effects of non-electrophilic agonists and antagonists). The binding properties of the mutant receptors were analyzed by in silico molecular docking. Functional changes were tested by in vitro methods: calcium sensitive fluorescent flow cytometry, whole-cell patch-clamp and radioactive calcium-45 liquid scintillation counting. Results: The cysteines forming the conventional binding site of electrophilic agonists, namely C621, C641 and C665 also bind the organic polysulfides, with the key role of C621. However, only their combined mutation abolished completely the organic polysulfide-induced activation of the receptor. Discussion: Since previous papers provided evidence that organic polysulfides exert analgesic and anti-inflammatory actions in different in vivo animal models, we anticipate that the development of TRPA1-targeted, organic polysulfide-based drugs will be promoted by this identification of the binding site.
    Type of Medium: Online Resource
    ISSN: 1664-042X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2564217-0
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  • 6
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-05-12)
    Abstract: Pancreatic necrosis is a consistent prognostic factor in acute pancreatitis (AP). However, the clinical scores currently in use are either too complicated or require data that are unavailable on admission or lack sufficient predictive value. We therefore aimed to develop a tool to aid in necrosis prediction. The XGBoost machine learning algorithm processed data from 2387 patients with AP. The confidence of the model was estimated by a bootstrapping method and interpreted via the 10th and the 90th percentiles of the prediction scores. Shapley Additive exPlanations (SHAP) values were calculated to quantify the contribution of each variable provided. Finally, the model was implemented as an online application using the Streamlit Python-based framework. The XGBoost classifier provided an AUC value of 0.757. Glucose, C-reactive protein, alkaline phosphatase, gender and total white blood cell count have the most impact on prediction based on the SHAP values. The relationship between the size of the training dataset and model performance shows that prediction performance can be improved. This study combines necrosis prediction and artificial intelligence. The predictive potential of this model is comparable to the current clinical scoring systems and has several advantages over them.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
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  • 7
    Online Resource
    Online Resource
    OMICS Publishing Group ; 2014
    In:  European Journal for Biomedical Informatics ( 2014)
    In: European Journal for Biomedical Informatics, OMICS Publishing Group, ( 2014)
    Type of Medium: Online Resource
    ISSN: 1801-5603
    Language: Unknown
    Publisher: OMICS Publishing Group
    Publication Date: 2014
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  • 8
    In: European Journal of Organic Chemistry, Wiley, Vol. 2013, No. 15 ( 2013-05), p. 2994-3004
    Type of Medium: Online Resource
    ISSN: 1434-193X
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1475010-7
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  • 9
    In: Clinical and Translational Medicine, Wiley, Vol. 12, No. 6 ( 2022-06)
    Abstract: Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 h to predict the severity; therefore, the early therapeutic window is often missed. Methods The early achievable severity index (EASY) is a multicentre, multinational, prospective and observational study (ISRCTN10525246). The predictions were made using machine learning models. We used the scikit‐learn, xgboost and catboost Python packages for modelling. We evaluated our models using fourfold cross‐validation, and the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and accuracy metrics were calculated on the union of the test sets of the cross‐validation. The most critical factors and their contribution to the prediction were identified using a modern tool of explainable artificial intelligence called SHapley Additive exPlanations (SHAP). Results The prediction model was based on an international cohort of 1184 patients and a validation cohort of 3543 patients. The best performing model was an XGBoost classifier with an average AUC score of 0.81 ± 0.033 and an accuracy of 89.1%, and the model improved with experience. The six most influential features were the respiratory rate, body temperature, abdominal muscular reflex, gender, age and glucose level. Using the XGBoost machine learning algorithm for prediction, the SHAP values for the explanation and the bootstrapping method to estimate confidence, we developed a free and easy‐to‐use web application in the Streamlit Python‐based framework (http://easy‐app.org/). Conclusions The EASY prediction score is a practical tool for identifying patients at high risk for severe AP within hours of hospital admission. The web application is available for clinicians and contributes to the improvement of the model.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2697013-2
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  • 10
    In: Acta Technica Jaurinensis, Szechenyi Istvan University, Vol. 14, No. 4 ( 2021-11-12), p. 488-507
    Abstract: In our days, simulation based development is a core element of vehicle engineering, especially considering highly automated or fully autonomous vehicles. Accordingly, the paper presents a benchmark of three different automotive simulators: PreScan, IPG CarMaker, and VTD Vires. The three software tools were applied for the same goal, namely, modelling the ZalaZONE Proving Ground of Hungary for vehicle testing. The paper aims to highlight the experiences while creating the virtual models by presenting and comparing the relevant software features and providing suggestions for scientific or practical application.
    Type of Medium: Online Resource
    ISSN: 2064-5228
    Language: Unknown
    Publisher: Szechenyi Istvan University
    Publication Date: 2021
    detail.hit.zdb_id: 2812545-9
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