In:
Frontiers in Pediatrics, Frontiers Media SA, Vol. 11 ( 2023-6-16)
Abstract:
The intestinal microbiome forms a major reservoir for antibiotic resistance genes (ARGs). Little is known about the neonatal intestinal resistome. Objective The objective of this study was to investigate the intestinal resistome and factors that influence the abundance of ARGs in a large cohort of neonates. Methods Shotgun metagenomics was used to analyse the resistome in stool samples collected at 1 week of age from 390 healthy, term-born neonates who did not receive antibiotics. Results Overall, 913 ARGs belonging to 27 classes were identified. The most abundant ARGs were those conferring resistance to tetracyclines, quaternary ammonium compounds, and macrolide-lincosamide-streptogramin-B. Phylogenetic composition was strongly associated with the resistome composition. Other factors that were associated with the abundance of ARGs were delivery mode, gestational age, birth weight, feeding method, and antibiotics in the last trimester of pregnancy. Sex, ethnicity, probiotic use during pregnancy, and intrapartum antibiotics had little effect on the abundance of ARGs. Conclusion Even in the absence of direct antibiotic exposure, the neonatal intestine harbours a high abundance and a variety of ARGs.
Type of Medium:
Online Resource
ISSN:
2296-2360
DOI:
10.3389/fped.2023.1169651
DOI:
10.3389/fped.2023.1169651.s001
DOI:
10.3389/fped.2023.1169651.s002
DOI:
10.3389/fped.2023.1169651.s003
DOI:
10.3389/fped.2023.1169651.s004
DOI:
10.3389/fped.2023.1169651.s005
DOI:
10.3389/fped.2023.1169651.s006
DOI:
10.3389/fped.2023.1169651.s007
DOI:
10.3389/fped.2023.1169651.s008
DOI:
10.3389/fped.2023.1169651.s009
DOI:
10.3389/fped.2023.1169651.s010
DOI:
10.3389/fped.2023.1169651.s011
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
2711999-3
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