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  • 1
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2018-12-06)
    Abstract: Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders. Here we provide evidence of a network of immunoglobulin G (IgG) autoantibodies targeting G protein-coupled receptors (GPCR) in HD compared to patients with systemic sclerosis, Alzheimer’s disease, and ovarian cancer. Sex, age and pathological conditions affect autoantibody correlation and hierarchical clustering signatures, yet many of the correlations are shared across all groups, indicating alterations to homeostasis. Furthermore, we identify relationships between autoantibodies targeting structurally and functionally related molecules, such as vascular, neuronal or chemokine receptors. Finally, autoantibodies targeting the endothelin receptor type A (EDNRA) exhibit chemotactic activity, as demonstrated by neutrophil migration toward HD-IgG in an EDNRA-dependent manner and in the direction of IgG from EDNRA-immunized mice. Our data characterizing the in vivo signatures of anti-GPCR autoantibodies thus suggest that they are a physiological part of the immune system.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2553671-0
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2013
    In:  Government Information Quarterly Vol. 30, No. 3 ( 2013-07), p. 217-225
    In: Government Information Quarterly, Elsevier BV, Vol. 30, No. 3 ( 2013-07), p. 217-225
    Type of Medium: Online Resource
    ISSN: 0740-624X
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 231678-X
    detail.hit.zdb_id: 2021001-2
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  • 3
    Online Resource
    Online Resource
    Springer Fachmedien Wiesbaden GmbH ; 2020
    In:  HMD Praxis der Wirtschaftsinformatik Vol. 57, No. 6 ( 2020-12), p. 1111-1129
    In: HMD Praxis der Wirtschaftsinformatik, Springer Fachmedien Wiesbaden GmbH, Vol. 57, No. 6 ( 2020-12), p. 1111-1129
    Abstract: Robotic Process Automation (RPA) is a technology that allows the easy development of computer programs (i.e., bots) which automate computerized business processes through the usage of Graphical User Interfaces. Current publications show that successful RPA implementations especially require a realistic management of stakeholder expectations and an in-depth process analysis. These results underline the need for decision support models to estimate impact of RPA on business processes, and, as such, prioritize business processes for RPA implementation. In this article we present results of an iterative Design Science Research project. The project was conducted in the context of a medium-sized industrial company. The overall aim is to create and evaluate a new scoring model for the prioritization of business processes for automation. The created model offers systematic support in evaluating different processes, ranks these processes with regards to monetary, technological and process-oriented criteria and, thus, allows a prioritization of processes.
    Type of Medium: Online Resource
    ISSN: 1436-3011 , 2198-2775
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    Language: German
    Publisher: Springer Fachmedien Wiesbaden GmbH
    Publication Date: 2020
    detail.hit.zdb_id: 1015731-1
    detail.hit.zdb_id: 2109643-0
    SSG: 3,2
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  • 4
    Online Resource
    Online Resource
    Emerald ; 2011
    In:  Business Process Management Journal Vol. 17, No. 3 ( 2011-06-07), p. 384-402
    In: Business Process Management Journal, Emerald, Vol. 17, No. 3 ( 2011-06-07), p. 384-402
    Abstract: The purpose of this paper is to analyze the status quo with regards to business process management (BPM) and collaboration and to show potential fields of future research in the area of collaborative BPM. Design/methodology/approach To obtain results, authors employ the method of a systematic literature review using relevant existing guidelines. They not only search leading journals and conferences in the fields but also in ISI web of knowledge's web of science. Subsuming, 39 relevant articles are selected and analyzed with regards to concepts identified upfront. Findings The paper finds that collaborative BPM is a growing trend in information systems research, but that there still exist significant research gaps. Hence, it proposes a research agenda consisting out of five action fields pointing at potentially fruitful directions for future research. Research limitations/implications First, this paper provides an overview of the status quo in the field of collaborative BPM to young scholars. Second, it identifies five distinct research gaps that could be worth studying. However, this paper may be limited by the choice of dimensions and the selection of relevant articles. Practical implications This paper informs practitioners about the status quo of research on collaborative BPM. Here, especially the analysis in the dimensions collaboration partner and BPM goals can help to evaluate the practitioner's strategy. Originality/value The results of this paper present the status quo of collaborative BPM literature. Hence, it also identifies research gaps and derives a research agenda.
    Type of Medium: Online Resource
    ISSN: 1463-7154
    Language: English
    Publisher: Emerald
    Publication Date: 2011
    detail.hit.zdb_id: 2014421-0
    SSG: 3,2
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  • 5
    Online Resource
    Online Resource
    Informa UK Limited ; 2014
    In:  European Journal of Information Systems Vol. 23, No. 6 ( 2014-11), p. 708-726
    In: European Journal of Information Systems, Informa UK Limited, Vol. 23, No. 6 ( 2014-11), p. 708-726
    Type of Medium: Online Resource
    ISSN: 0960-085X , 1476-9344
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2017334-9
    SSG: 24,1
    SSG: 3,2
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  • 6
    Online Resource
    Online Resource
    American Accounting Association ; 2022
    In:  Journal of Information Systems Vol. 36, No. 2 ( 2022-06-01), p. 173-191
    In: Journal of Information Systems, American Accounting Association, Vol. 36, No. 2 ( 2022-06-01), p. 173-191
    Abstract: Robotic Process Automation (RPA) is a relatively new approach to automate business processes in organizations. Practitioners have adopted it extensively, notably within the accounting discipline; however, the scientific research seems to be lagging. As a result of this, there is no clear definition or uniform understanding of the advantages and disadvantages of RPA. To close this gap, we conducted a structured and systematic literature review of published scholarly articles on RPA. We set out to identify the definition of RPA, consider its feasibility regarding implementation, outline the advantages and disadvantages, and evaluate the risks and best practices of RPA. In this paper, we show that the literature has particularly failed to discuss the quantifiable benefits of RPA. The best practices identified are especially relevant for practitioners. Based on our findings, we propose an agenda for future research on RPA.
    Type of Medium: Online Resource
    ISSN: 1558-7959 , 0888-7985
    Language: English
    Publisher: American Accounting Association
    Publication Date: 2022
    detail.hit.zdb_id: 2068800-3
    SSG: 24,1
    SSG: 3,2
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  • 7
    Online Resource
    Online Resource
    Wiley ; 2023
    In:  Nonprofit Management and Leadership
    In: Nonprofit Management and Leadership, Wiley
    Abstract: Despite substantial innovations in Information and Communication Technologies (ICT) that could benefit non‐governmental organizations (NGOs), NGOs are not using ICT yet to their full potential – especially compared to the ICT use in the private sector. Such behavior appears counterintuitive as one would expect NGOs to use every available resource to further their important mission. However, reservations appear to remain even though several case studies demonstrated the value ICT can generate for NGOs. Through a series of 20 interviews with NGOs of various sizes and backgrounds, we examined the use of ICT along the NGO value chain (program design, fundraising, fund management, and program delivery). We find a distinct prioritization of ICT support along the value chain. Based on these findings, we identify six sector‐specific reasons for NGOs not to use ICT for certain activities. With these, we add to known reasons in the literature and offer important avenues for further research.
    Type of Medium: Online Resource
    ISSN: 1048-6682 , 1542-7854
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2069718-1
    SSG: 3,2
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  • 8
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2022
    In:  Information Systems and e-Business Management Vol. 20, No. 4 ( 2022-12), p. 789-818
    In: Information Systems and e-Business Management, Springer Science and Business Media LLC, Vol. 20, No. 4 ( 2022-12), p. 789-818
    Abstract: The information systems, e-business, and e-government literature has unanimously shown that trust and risk are antecedents of the use of information technology and technology-based services. However, a deeper understanding of the relationship between trust and risk, especially when taking into account the extensive knowledge created in fields such as organisational science and psychology, is often missing. With this article, we aim at conceptualizing risk in e-government use. Based on a structured review of the trust-related e-government literature, we derive a typology of relevant e-government risks. We analyse this typology in light of extant trust and risk literature. The typology can be used both to understand the behaviour of system or service users and to design systems and services that can be and are trusted. As such, this research can serve as a basis for future research on the role of trust and risk in designing and using e-government services. The generalizability to e-business services and information systems in general is discussed.
    Type of Medium: Online Resource
    ISSN: 1617-9846 , 1617-9854
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2173306-5
    SSG: 3,2
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  • 9
    Online Resource
    Online Resource
    Emerald ; 2014
    In:  Business Process Management Journal Vol. 20, No. 1 ( 2014-1-28), p. 90-106
    In: Business Process Management Journal, Emerald, Vol. 20, No. 1 ( 2014-1-28), p. 90-106
    Abstract: – Business process management (BPM) is a key concept in information systems (IS) research that helps to connect business strategy with the use of technology in an organization. Contemporary BPM research is no longer only about methods, procedures, or tools for managing or modeling processes but about assessing and developing BPM capability in organizations. For this purpose, a vast collection of maturity models has been designed by practitioners and scholars alike. Such models are used to assess the status quo and benchmark it against other organizations, and, most important, to guide the development of BPM capability. With this study, the paper challenges the maturity model perspective of such development models. Design/methodology/approach – In this study, methods of qualitative IS research are employed to address the research objectives. Findings – The paper shows that maturity model-based guidance would be inadequate. Instead, other concept-external factors resulting from organizational and environmental characteristics appear to be important indicators. The theory discussion introduces alternative takes on BPM capability development, lays out implications for BPM practice, and presents potentially fruitful paths for future research in the area of BPM capability development. Originality/value – This paper challenges the current perspectives and contributes a new direction for conceptualizing BPM capability development.
    Type of Medium: Online Resource
    ISSN: 1463-7154
    Language: English
    Publisher: Emerald
    Publication Date: 2014
    detail.hit.zdb_id: 2014421-0
    SSG: 3,2
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  • 10
    Online Resource
    Online Resource
    Emerald ; 2012
    In:  Business Process Management Journal Vol. 18, No. 2 ( 2012-04-13), p. 347-371
    In: Business Process Management Journal, Emerald, Vol. 18, No. 2 ( 2012-04-13), p. 347-371
    Abstract: Business process management (BPM) networks have become an important theme in both research and practice. Drawing from governance theory, this paper seeks to provide a theoretical understanding of BPM networks and introduce three types of BPM governance: market, network, and hierarchy. Subsequently, it aims to study the impact of BPM maturity, organization size, and financial stress (independent variables) on the three types of BPM governance (dependent variable). Design/methodology/approach After a thorough literature analysis a quantitative study is conducted. Comprehensive data of 538 local public administration in Germany and Japan is comparatively studied by means of a PLS (model and multi group) analysis. Findings The empirical study provides evidence for the significant dependence of BPM governance on contextual variables: the configuration of the BPM network relies on the BPM maturity and the perceived financial stress. Also, such dependence does vary between the two countries. Higher financial stress leads to more higher network sourcing in Germany and to higher market sourcing in Japan, respectively. Practical implications This study suggests that the role of process managers changes over time. In immature organizations, process managers appear to work alone and struggle for resources. However, once organizations start to mature, the role changes to that of an “orchestrator of different actors.” Process managers in future public organizations (assuming a positive development of capabilities), both in Asian and European settings, must be able to collaborate with actors from different governance mechanisms. Originality/value First, the paper provides a governance‐theory based understanding of BPM networks. It introduces market‐type, network‐type, and hierarchy‐type BPM governance and thereby provides greater conceptual and theoretical clarity of this important phenomenon. So far, this research area has been under‐theorized. Second, the paper provides a theory that explains BPM network governance. Here, relevant contextual variables are taken into account, including the BPM maturity of an organization. Third, the paper contributes comprehensive empirical insights into BPM networks structures, governance mechanisms, and their dependence on contextual variables (especially the BPM maturity of an organization). Fourth, it provides an ample comparative theory‐based analysis of BPM networks in two different countries. Such an endeavor, as to the author's best knowledge, has not yet been undertaken so far.
    Type of Medium: Online Resource
    ISSN: 1463-7154
    Language: English
    Publisher: Emerald
    Publication Date: 2012
    detail.hit.zdb_id: 2014421-0
    SSG: 3,2
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