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A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development

Faca, Vitor M ; Song, Kenneth S ; Wang, Hong ; [et al.]

Public Library of Science (PLoS) ; 2008

In: PLoS Medicine Vol. 5, No. 6 ( 2008-6-10), p. e123-

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In: PLoS Medicine, Public Library of Science (PLoS), Vol. 5, No. 6 ( 2008-6-10), p. e123-

Type of Medium: Online Resource

ISSN: 1549-1676

URL: Article

DOI: 10.1371/journal.pmed.0050123

DOI: 10.1371/journal.pmed.0050123.g001

DOI: 10.1371/journal.pmed.0050123.g002

DOI: 10.1371/journal.pmed.0050123.g003

DOI: 10.1371/journal.pmed.0050123.g004

DOI: 10.1371/journal.pmed.0050123.g005

DOI: 10.1371/journal.pmed.0050123.g006

DOI: 10.1371/journal.pmed.0050123.t001

DOI: 10.1371/journal.pmed.0050123.t002

DOI: 10.1371/journal.pmed.0050123.sg001

DOI: 10.1371/journal.pmed.0050123.sg002

DOI: 10.1371/journal.pmed.0050123.sg003

DOI: 10.1371/journal.pmed.0050123.sg004

DOI: 10.1371/journal.pmed.0050123.sg005

DOI: 10.1371/journal.pmed.0050123.st001

DOI: 10.1371/journal.pmed.0050123.st002

DOI: 10.1371/journal.pmed.0050123.st003

DOI: 10.1371/journal.pmed.0050123.st004

DOI: 10.1371/journal.pmed.0050123.st005

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2008

detail.hit.zdb_id: 2164823-2

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Patients with Advanced Pancreatic Cancer and Hyperbilirubinaemia: Review and German Expert Opinion on Treatment with nab-Paclitaxel plus Gemcitabine

Vogel, Arndt ; Kullmann, Frank ; Kunzmann, Volker ; [et al.]

S. Karger AG ; 2015

In: Oncology Research and Treatment Vol. 38, No. 11 ( 2015), p. 596-603

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In: Oncology Research and Treatment, S. Karger AG, Vol. 38, No. 11 ( 2015), p. 596-603

Abstract: In patients with advanced unresectable pancreatic cancer, the prognosis is generally poor. Within recent years, new treatment options such as the FOLFIRINOX regimen (5-fluorouracil, leucovorin, irinotecan and oxaliplatin) or the combination of nanoparticle albumin-bound (nab)-paclitaxel plus gemcitabine have shown a clinically relevant survival benefit over the standard gemcitabine in patients with good performance status. Unfortunately, patients with hyperbilirubinaemia, who constitute a substantial proportion of the pancreatic cancer patients, have been excluded from most clinical studies. Consequently, our knowledge on the appropriate medical treatment of this patient group is limited. In a meeting of German medical oncology experts, the available clinical evidence and own clinical experience regarding the management of patients with advanced pancreatic cancer and hyperbilirubinaemia was discussed. The present publication summarises the discussion outcomes with regard to appropriate management of these patients, including consensus-based recommendations for nab-paclitaxel/gemcitabine treatment, according to the best available evidence. In summary, knowledge of the underlying aetiology of hyperbilirubinaemia and the metabolisation routes of the cytotoxic drugs is crucial before initiating chemotherapy. As effective treatment options should also be made available to patients with comorbid conditions, including hyperbilirubinaemia, the experts provide advice for an initial dose reduction of chemotherapy with nab-paclitaxel/gemcitabine based on the total bilirubin level in patients with biliary obstruction or extensive liver metastasis.

Type of Medium: Online Resource

ISSN: 2296-5270 , 2296-5262

URL: Article

DOI: 10.1159/000441310

Language: English

Publisher: S. Karger AG

Publication Date: 2015

detail.hit.zdb_id: 2749752-5

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Primäre Lebertumoren

Nadalin, Silvio ; Königsrainer, Alfred ; Capobianco, Ivan ; [et al.]

Georg Thieme Verlag KG ; 2016

In: Interventionelle Radiologie Scan Vol. 04, No. 02 ( 2016-6-3), p. 159-171

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In: Interventionelle Radiologie Scan, Georg Thieme Verlag KG, Vol. 04, No. 02 ( 2016-6-3), p. 159-171

Type of Medium: Online Resource

ISSN: 2196-2510 , 2196-2529

URL: Issue

URL: Journal

URL: Article

DOI: 10.1055/s-006-31859

DOI: 10.1055/s-00024754

DOI: 10.1055/s-0042-106699

Language: German

Publisher: Georg Thieme Verlag KG

Publication Date: 2016

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Islet microarchitecture and glucose transporter expression of the pancreas of the marmoset monkey display similarities to the human

Plentz, Ruben R. ; Palagani, Vindhya ; Wiedemann, Anastasia ; [et al.]

Informa UK Limited ; 2012

In: Islets Vol. 4, No. 2 ( 2012-03), p. 123-129

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In: Islets, Informa UK Limited, Vol. 4, No. 2 ( 2012-03), p. 123-129

Type of Medium: Online Resource

ISSN: 1938-2014 , 1938-2022

URL: Article

DOI: 10.4161/isl.19254

Language: English

Publisher: Informa UK Limited

Publication Date: 2012

detail.hit.zdb_id: 2589489-4

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Haprolid Inhibits Tumor Growth of Hepatocellular Carcinoma through Rb/E2F and Akt/mTOR Inhibition

Xing, Jun ; Bhuria, Vikas ; Bui, Khac Cuong ; [et al.]

MDPI AG ; 2020

In: Cancers Vol. 12, No. 3 ( 2020-03-06), p. 615-

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In: Cancers, MDPI AG, Vol. 12, No. 3 ( 2020-03-06), p. 615-

Abstract: Background: Hepatocellular carcinoma (HCC) represents a major health burden with limited curative treatment options. There is a substantial unmet need to develop innovative approaches to impact the progression of advanced HCC. Haprolid is a novel natural component isolated from myxobacteria. Haprolid has been reported as a potent selective cytotoxin against a panel of tumor cells in recent studies including HCC cells. The aims of this study are to evaluate the antitumor effect of haprolid in HCC and to understand its underlying molecular mechanisms. Methods: The efficacy of haprolid was evaluated in human HCC cell lines (Huh-7, Hep3B and HepG2) and xenograft tumors (NMRI-Foxn1nu mice with injection of Hep3B cells). Cytotoxic activity of haprolid was determined by the WST-1 and crystal violet assay. Wound healing, transwell and tumorsphere assays were performed to investigate migration and invasion of HCC cells. Apoptosis and cell-cycle distribution were measured by flow cytometry. The effects of haprolid on the Rb/E2F and Akt/mTOR pathway were examined by immunoblotting and immunohistochemistry. Results: haprolid treatment significantly inhibited cell proliferation, migration and invasion in vitro. The epithelial–mesenchymal transition (EMT) was impaired by haprolid treatment and the expression level of N-cadherin, vimentin and Snail was downregulated. Moreover, growth of HCC cells in vitro was suppressed by inhibition of G1/S transition, and partially by induction of apoptosis. The drug induced downregulation of cell cycle regulatory proteins cyclin A, cyclin B and CDK2 and induced upregulation of p21 and p27. Further evidence showed that these effects of haprolid were associated with Rb/E2F downregulation and Akt/mTOR inhibition. Finally, in vivo nude mice experiments demonstrated significant inhibition of tumor growth upon haprolid treatment. Conclusion: Our results show that haprolid inhibits the growth of HCC through dual inhibition of Rb/E2F and Akt/mTOR pathways. Therefore, haprolid might be considered as a new and promising candidate for the palliative therapy of HCC.

Type of Medium: Online Resource

ISSN: 2072-6694

URL: Article

DOI: 10.3390/cancers12030615

Language: English

Publisher: MDPI AG

Publication Date: 2020

detail.hit.zdb_id: 2527080-1

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Scarring mucous membrane pemphigoid presenting as double stenosis of the larynx and esophagus: precautions during therapy can avoid complications

Schempf, Ulrike ; Plentz, Ruben ; Stueker, Dietmar ; [et al.]

Georg Thieme Verlag KG ; 2014

In: Endoscopy Vol. 46, No. S 01 ( 2014-12-11), p. E617-E618

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In: Endoscopy, Georg Thieme Verlag KG, Vol. 46, No. S 01 ( 2014-12-11), p. E617-E618

Type of Medium: Online Resource

ISSN: 0013-726X , 1438-8812

URL: Issue

URL: Journal

URL: Article

DOI: 10.1055/s-004-26288

DOI: 10.1055/s-00000012

DOI: 10.1055/s-0034-1390755

RVK:

XA 41100

RVK:

YC 4905

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2014

detail.hit.zdb_id: 2026213-9

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Clinical features, etiology, and survival of hepatocellular carcinoma among different countries

OMATA, MASAO ; DAN, YOSHIYUKI ; DANIELE, BRUNO ; [et al.]

Wiley ; 2002

In: Journal of Gastroenterology and Hepatology Vol. 17, No. s1 ( 2002-02)

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In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 17, No. s1 ( 2002-02)

Type of Medium: Online Resource

ISSN: 0815-9319 , 1440-1746

URL: Article

DOI: 10.1046/j.1440-1746.17.s1.14.x

Language: English

Publisher: Wiley

Publication Date: 2002

detail.hit.zdb_id: 2006782-3

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Targeting interleukin 6 signaling by monoclonal antibody siltuximab on cholangiocarcinoma

Nguyen, Mai Ly Thi ; Bui, Khac Cuong ; Scholta, Tim ; [et al.]

Wiley ; 2021

In: Journal of Gastroenterology and Hepatology Vol. 36, No. 5 ( 2021-05), p. 1334-1345

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In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 36, No. 5 ( 2021-05), p. 1334-1345

Abstract: Cholangiocarcinoma has an unimproved prognosis. Interleukin 6 (IL‐6) has an oncogenic potential in some cancer diseases. However, the role of IL‐6 in cholangiocarcinoma carcinogenesis is not well understood. The current study investigated the role of IL‐6 signaling in cholangiocarcinoma carcinogenesis and efficacy of siltuximab treatment on cholangiocarcinoma in vitro and in vivo . Methods The expression of IL‐6 was analyzed on human cholangiocarcinoma cell lines and murine and human cholangiocarcinoma tissues, using reverse transcription real‐time polymerase chain reaction and immunohistochemistry. In addition, the effect of anti‐IL‐6 chimeric monoclonal antibody, siltuximab, was investigated in vitro by proliferation, migration, and two‐dimensional and three‐dimensional invasion assays and in vivo by xenograft mouse model. Western blot was applied to study the molecular alteration. Results Our result shows high expression of IL‐6 in human cholangiocarcinoma cells, and IL‐6 stimulants enhance cholangiocarcinoma cell proliferation. In addition, murine and human cholangiocarcinoma tissues express significantly higher levels of IL‐6, compared with adjacent non‐tumor tissues. On the cholangiocarcinoma engineered mouse model, IL‐6 level is associated with tumor volume. Taken together, our data indicate an oncogenic potential of IL‐6 in cholangiocarcinoma carcinogenesis. Siltuximab sufficiently abrogates IL‐6 signaling and inhibits cholangiocarcinoma progression in vitro and in vivo . The results additionally indicate a relative alteration of IL‐6 signaling and its molecular targets, such as STAT3, Wnt/β‐catenin, and mesenchymal markers. Conclusions Interleukin 6 plays an essential role in cholangiocarcinoma carcinogenesis, and siltuximab has the potential to be considered as a new treatment option for cholangiocarcinoma patients.

Type of Medium: Online Resource

ISSN: 0815-9319 , 1440-1746

URL: Issue

URL: Article

DOI: 10.1111/jgh.v36.5

DOI: 10.1111/jgh.15307

Language: English

Publisher: Wiley

Publication Date: 2021

detail.hit.zdb_id: 2006782-3

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Hepatocellular carcinoma and octreotide: Treatment results in prospectively assigned patients with advanced tumor and cirrhosis stage

PLENTZ, RUBEN R ; TILLMANN, HANS L ; KUBICKA, STEFAN ; [et al.]

Wiley ; 2005

In: Journal of Gastroenterology and Hepatology Vol. 20, No. 9 ( 2005-09), p. 1422-1428

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In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 20, No. 9 ( 2005-09), p. 1422-1428

Type of Medium: Online Resource

ISSN: 0815-9319 , 1440-1746

URL: Issue

URL: Article

DOI: 10.1111/jgh.2005.20.issue-9

DOI: 10.1111/j.1440-1746.2005.03959.x

Language: English

Publisher: Wiley

Publication Date: 2005

detail.hit.zdb_id: 2006782-3

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S3-Leitlinie: Diagnostik und Therapie des hepatozellulären Karzinoms : Langversion 2.0 – Juni 2021, AWMF-Registernummer: 032-053OL

Sabrina, Voesch ; Michael, Bitzer ; Jörg, Albert ; [et al.]

Georg Thieme Verlag KG ; 2022

In: Zeitschrift für Gastroenterologie Vol. 60, No. 01 ( 2022-01), p. e56-e130

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In: Zeitschrift für Gastroenterologie, Georg Thieme Verlag KG, Vol. 60, No. 01 ( 2022-01), p. e56-e130

Type of Medium: Online Resource

ISSN: 0044-2771 , 1439-7803

URL: Article

DOI: 10.1055/a-1589-7568

RVK:

XA 10000

Language: German

Publisher: Georg Thieme Verlag KG

Publication Date: 2022

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