In:
Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 67, No. 9 ( 1989-09-01), p. 1062-1066
Abstract:
The metabolic effect of intravenous infusion of ammonium chloride (60 μmol/(kg body weight∙min)) was compared in five sheep before and after adrenal denervation. Adrenal denervation completely abolished the hyperglycemic effect of ammonium chloride, diminished the rise of pyruvate and lactate concentration, and failed to influence the lipolytic effect of NH 4 Cl It is suggested that the metabolic effects of ammonia are in a different degree related to the action of ammonia on the central nervous system and (i) the hyperammonemic effect of ammonia completely depends on the neurogenic increase of adrenal medullary hormones; (ii) the rise of blood lactate and pyruvate level observed during hyperammonemia is only partially mediated by adrenaline; and (iii) the lipolytic effect of ammonia ion does not depend on the nerve-controlled secretion of adrenal medullary hormones.Key words: adrenal denervation, hyperammonemia, metabolism, sheep.
Type of Medium:
Online Resource
ISSN:
0008-4212
,
1205-7541
Language:
English
Publisher:
Canadian Science Publishing
Publication Date:
1989
detail.hit.zdb_id:
2004356-9
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