In:
Natural Product Communications, SAGE Publications, Vol. 7, No. 7 ( 2012-07), p. 1934578X1200700-
Abstract:
Antioxidant activities of minor pigments of sea urchins (1–5) and synthetic naphthazarins (7–13) were evaluated and compared with echinochrome A (6) using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) scavenging assays. Structure-activity relationships showed that the antioxidant activities of the tested compounds depended on the number and positions of hydroxyl groups. Compounds bearing 3 or 2 hydroxyl groups on a naphthazarin core (5,8-dihydroxy-1,4-naphthoquinone) were the most active in both assays. Echinochrome A (6) (IC 50 7.0 μM) and its monomethyl ethers 7 (IC 50 15.0 μM) and 8 (IC 50 15.0 μM) displayed stronger activities than Trolox (IC 50 16.0 μM) in the DPPH and ABTS assays (TE = 3.41, 2.35, and 2.35 mM, respectively). Compounds with either one or without hydroxyl groups on a naphthazarin core displayed activities significantly lower than Trolox in both assays. These results suggest that hydroxylated naphthazarin pigments of sea urchins have a potential use as natural antioxidants.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X1200700725
Language:
English
Publisher:
SAGE Publications
Publication Date:
2012
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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