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Comprehensive cancer-oriented biobanking resource of human samples for studies of post-zygotic genetic variation involved in cancer predisposition

Filipowicz, Natalia ; Drężek, Kinga ; Horbacz, Monika ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS ONE Vol. 17, No. 4 ( 2022-4-7), p. e0266111-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 4 ( 2022-4-7), p. e0266111-

Abstract: The progress in translational cancer research relies on access to well-characterized samples from a representative number of patients and controls. The rationale behind our biobanking are explorations of post-zygotic pathogenic gene variants, especially in non-tumoral tissue, which might predispose to cancers. The targeted diagnoses are carcinomas of the breast (via mastectomy or breast conserving surgery), colon and rectum, prostate, and urinary bladder (via cystectomy or transurethral resection), exocrine pancreatic carcinoma as well as metastases of colorectal cancer to the liver. The choice was based on the high incidence of these cancers and/or frequent fatal outcome. We also collect age-matched normal controls. Our still ongoing collection originates from five clinical centers and after nearly 2-year cooperation reached 1711 patients and controls, yielding a total of 23226 independent samples, with an average of 74 donors and 1010 samples collected per month. The predominant diagnosis is breast carcinoma, with 933 donors, followed by colorectal carcinoma (383 donors), prostate carcinoma (221 donors), bladder carcinoma (81 donors), exocrine pancreatic carcinoma (15 donors) and metachronous colorectal cancer metastases to liver (14 donors). Forty percent of the total sample count originates from macroscopically healthy cancer-neighboring tissue, while contribution from tumors is 12%, which adds to the uniqueness of our collection for cancer predisposition studies. Moreover, we developed two program packages, enabling registration of patients, clinical data and samples at the participating hospitals as well as the central system of sample/data management at coordinating center. The approach used by us may serve as a model for dispersed biobanking from multiple satellite hospitals. Our biobanking resource ought to stimulate research into genetic mechanisms underlying the development of common cancers. It will allow all available “-omics” approaches on DNA-, RNA-, protein- and tissue levels to be applied. The collected samples can be made available to other research groups.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0266111

DOI: 10.1371/journal.pone.0266111.g001

DOI: 10.1371/journal.pone.0266111.g002

DOI: 10.1371/journal.pone.0266111.g003

DOI: 10.1371/journal.pone.0266111.g004

DOI: 10.1371/journal.pone.0266111.g005

DOI: 10.1371/journal.pone.0266111.g006

DOI: 10.1371/journal.pone.0266111.t001

DOI: 10.1371/journal.pone.0266111.t002

DOI: 10.1371/journal.pone.0266111.t003

DOI: 10.1371/journal.pone.0266111.s001

DOI: 10.1371/journal.pone.0266111.s002

DOI: 10.1371/journal.pone.0266111.r001

DOI: 10.1371/journal.pone.0266111.r002

DOI: 10.1371/journal.pone.0266111.r003

DOI: 10.1371/journal.pone.0266111.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2267670-3

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Metaproteomic analysis from cervical biopsies and cytologies identifies proteinaceous biomarkers representing both human and microbial species

Faktor, Jakub ; Henek, Tomas ; Hernychova, Lenka ; [et al.]

Elsevier BV ; 2024

In: Talanta Vol. 278 ( 2024-10), p. 126460-

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In: Talanta, Elsevier BV, Vol. 278 ( 2024-10), p. 126460-

Type of Medium: Online Resource

ISSN: 0039-9140

URL: Article

DOI: 10.1016/j.talanta.2024.126460

RVK:

VA 7420

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 1500969-5

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Re: Henk G. van der Poel, Tessa Buckle, Oscar R. Brouwer, Renato A. Valdés Olmos, Fijs W.B. van Leeuwen. Intraoperative Laparoscopic Fluorescence Guidance to the Sentinel Lymph Node in Prostate Cancer Patients: Clinical Proof of Concept of an Integrated Functional Imaging Approach Using a Multimodal Tracer. Eur Urol 2011;60:826–33

Polom, Karol ; Murawa, Dawid ; Polom, Wojciech

Elsevier BV ; 2012

In: European Urology Vol. 61, No. 3 ( 2012-03), p. e18-

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In: European Urology, Elsevier BV, Vol. 61, No. 3 ( 2012-03), p. e18-

Type of Medium: Online Resource

ISSN: 0302-2838

URL: Article

DOI: 10.1016/j.eururo.2011.12.002

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1482253-2

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Fluorescence Imaging Using Methylene Blue Sentinel Lymph Node Biopsy in Melanoma

Cwalinski, Tomasz ; Skokowski, Jarosław ; Polom, Wojciech ; [et al.]

SAGE Publications ; 2022

In: Surgical Innovation Vol. 29, No. 4 ( 2022-08), p. 503-510

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In: Surgical Innovation, SAGE Publications, Vol. 29, No. 4 ( 2022-08), p. 503-510

Abstract: Fluorescence imaging of sentinel node biopsy in melanoma is a novel method. Both indocyanine green (ICG) and methylene blue (MB) have fluorescent properties. The aim of this study was to present, for the first time in a clinical series of patients, the possible usage of MB as a fluorescent dye for sentinel node biopsy during surgery for melanoma. Material and methods Twenty patients with skin melanoma, who were candidates for sentinel node biopsy were enrolled in our study. All patients underwent simultaneous use of standard nanocolloid and blue dye. Transcutaneous visualization of the sentinel node, visualization of lymphatic channels as well as sentinel node fluorescent visualization were all measured. We also performed calculations of Signal to Background ratios (SBR). Results In 15% (3/20) of patients, the fluorescent sentinel node was visible through the skin. The median SBR for the sentinel node visualization by fluorescence was 3.15 (range, 2.7–3.5). Lymphatic channels were visible in lymphatic tissue via fluorescence before visualization by the naked eye in 4 patients (20%). The median SBR ratio was 3.69 (range, 2.7–4.2). Sentinel nodes were visible by fluorescence in 13 cases (65%). The median SBR ratio was 2.49 (range, 1.5–5.7). No factors were found to be associated with fluorescent MB visualization of a sentinel node during biopsy. Conclusion This is the first clinical study presenting the usefulness of fluorescent sentinel node biopsy in melanoma patients using MB as a fluorophore. Further studies are necessary to provide methods for its’ clinical implementation.

Type of Medium: Online Resource

ISSN: 1553-3506 , 1553-3514

URL: Article

DOI: 10.1177/15533506221074601

Language: English

Publisher: SAGE Publications

Publication Date: 2022

detail.hit.zdb_id: 2233576-6

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Comprehensive Review of Fluorescence Applications in Gynecology

Polom, Joanna ; Kalinowski, Leszek ; Diana, Michele ; [et al.]

MDPI AG ; 2021

In: Journal of Clinical Medicine Vol. 10, No. 19 ( 2021-09-25), p. 4387-

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In: Journal of Clinical Medicine, MDPI AG, Vol. 10, No. 19 ( 2021-09-25), p. 4387-

Abstract: Since the introduction of indocyanine green (ICG) as a fluorophore in near-infrared imaging, fluorescence visualization has become an essential tool in many fields of surgery. In the field of gynecology, recent new applications have been proposed and found their place in clinical practice. Different applications in gynecology were investigated, subcategorized, and overviewed concerning surgical applications and available dyes. Specific applications in which fluorescence-guided surgery was implemented in gynecology are described in this manuscript—namely, sentinel node biopsy, mesometrium visualization, angiography of different organs, safety issues in pregnant women, ureters visualization, detection of peritoneal metastases, targeted fluorophores for cancer detection, fluorescent contamination hysterectomy, lymphography for lower limb lymphedema prevention, tumor margin detection, endometriosis, and metastases mapping. With evolving technology, further innovative research on the new applications of fluorescence visualization in cancer surgery may help to establish these techniques as standards of high-quality surgery in gynecology. However, more investigations are necessary in order to assess if these innovative tools can also be effective to improve patient outcomes and quality of life in different gynecologic malignancies.

Type of Medium: Online Resource

ISSN: 2077-0383

URL: Article

DOI: 10.3390/jcm10194387

Language: English

Publisher: MDPI AG

Publication Date: 2021

detail.hit.zdb_id: 2662592-1

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Multispectral Imaging Using Fluorescent Properties of Indocyanine Green and Methylene Blue in Colorectal Surgery—Initial Experience

Polom, Wojciech ; Migaczewski, Marcin ; Skokowski, Jaroslaw ; [et al.]

MDPI AG ; 2022

In: Journal of Clinical Medicine Vol. 11, No. 2 ( 2022-01-13), p. 368-

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In: Journal of Clinical Medicine, MDPI AG, Vol. 11, No. 2 ( 2022-01-13), p. 368-

Abstract: Introduction: Image-guided surgery is becoming a new tool in colorectal surgery. Intraoperative visualisation of different structures using fluorophores helps during various steps of operations. In our report, we used two fluorophores—indocyanine green (ICG), and methylene blue (MB)—during different steps of colorectal surgery, using one camera system for two separate near-infrared wavelengths. Material and methods: Twelve patients who underwent complex open or laparoscopic colorectal surgeries were enrolled. Intravenous injections of MB and ICG at different time points were administered. Visualisation of intraoperative ureter position and fluorescent angiography for optimal anastomosis was performed. A retrospective analysis of patients treated in our departments during 2020 was performed, and data about ureter injury and anastomotic site complications were collected. Results: Intraoperative localisation of ureters with MB under fluorescent light was possible in 11 patients. The mean signal-to-background ratio was 1.58 ± 0.71. Fluorescent angiography before performing anastomosis using ICG was successful in all 12 patients, and none required a change in position of the planned colon resection for anastomosis. The median signal-to-background ratios was 1.25 (IQR: 1.22–1.89). Across both centres, iatrogenic injury of the ureter was found in 0.4% of cases, and complications associated with anastomosis was found in 5.5% of cases. Conclusions: Our study showed a substantial opportunity for using two different fluorophores in colorectal surgery, whereby the visualisation of one will not change the possible quantification analysis of the other. Using two separate dyes during one procedure may help in optimisation of the fluorescent properties of both dyes when using them for different applications. Visualisation of different structures by different fluorophores seems to be the future of image-guided surgery, and shows progress in optical technologies used in image-guided surgery.

Type of Medium: Online Resource

ISSN: 2077-0383

URL: Article

DOI: 10.3390/jcm11020368

Language: English

Publisher: MDPI AG

Publication Date: 2022

detail.hit.zdb_id: 2662592-1

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Methylene Blue—Current Knowledge, Fluorescent Properties, and Its Future Use

Cwalinski, Tomasz ; Polom, Wojciech ; Marano, Luigi ; [et al.]

MDPI AG ; 2020

In: Journal of Clinical Medicine Vol. 9, No. 11 ( 2020-11-02), p. 3538-

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In: Journal of Clinical Medicine, MDPI AG, Vol. 9, No. 11 ( 2020-11-02), p. 3538-

Abstract: Methylene blue is a fluorescent dye discovered in 1876 and has since been used in different scientific fields. Only recently has methylene blue been used for intraoperative fluorescent imaging. Here, the authors review the emerging role of methylene blue, not only as a dye used in clinical practice, but also as a fluorophore in a surgical setting. We discuss the promising potential of methylene blue together with the challenges and limitations among specific surgical techniques. A literature review of PubMed and Medline was conducted based on the historical, current and future usage of methylene blue within the field of medicine. We reviewed not only the current usage of methylene blue, but we also tried to grasp its’ function as a fluorophore in five main domains. These domains include the near-infrared imaging visualization of ureters, parathyroid gland identification, pancreatic tumors imaging, detection of breast cancer tumor margins, as well as breast cancer sentinel node biopsy. Methylene blue is used in countless clinical procedures with a relatively low risk for patients. Usage of its fluorescent properties is still at an early stage and more pre-clinical, as well as clinical research, must be performed to fully understand its potentials and limitations.

Type of Medium: Online Resource

ISSN: 2077-0383

URL: Article

DOI: 10.3390/jcm9113538

Language: English

Publisher: MDPI AG

Publication Date: 2020

detail.hit.zdb_id: 2662592-1

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Data on the quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignancies: does it concern patients with gastric cancer?

Skierucha, Malgorzata ; Polom, Karol ; Rawicz-Pruszynski, Karol ; [et al.]

Walter de Gruyter GmbH ; 2017

In: Current Issues in Pharmacy and Medical Sciences Vol. 30, No. 4 ( 2017-12-1), p. 203-206

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In: Current Issues in Pharmacy and Medical Sciences, Walter de Gruyter GmbH, Vol. 30, No. 4 ( 2017-12-1), p. 203-206

Abstract: Introduction. So far there are no reports devoted exclusively to the quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in metastatic gastric cancer. Current literature concerning this issue was, thus, reviewed in order to: 1) search for such data concerning metastatic gastric cancer; 2) assess if the latest reviews evenly pertain to all peritoneal surface malignancies; and 3) conclude if they are a reliable source of data for patients with metastatic gastric cancer. Materials and Methods. The electronic PubMed/MEDLINE and EMBASE databases were retrieved for studies concerning the influence of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy on quality of life in patients with metastatic gastric cancer and regardless of initial diagnosis. The data on the number of patients with particular tumours were analysed and the results were presented in the form of a table. Results. Approximately half of all patients encompassed by the reviews had a form of primary peritoneal surface malignancies. Within peritoneal metastases, the most numerous were colorectal (21-24%) and ovarian cancers (5-15%). Gastric cancers and sarcomas were the smallest defined subgroups (4% each). Conclusions. The promising outcomes in quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in primary peritoneal surface malignancies might differ from rarely reported ones in metastatic gastric cancer. The problem needs further, gastric cancer-devoted investigations.

Type of Medium: Online Resource

ISSN: 2300-6676 , 2084-980X

URL: Article

DOI: 10.1515/cipms-2017-0039

Language: English

Publisher: Walter de Gruyter GmbH

Publication Date: 2017

detail.hit.zdb_id: 2733313-9

SSG: 15,3

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Apatinib: A novel receptor tyrosine kinase inhibitor for the treatment of gastric cancer

Roviello, Giandomenico ; Ravelli, Andrea ; Polom, Karol ; [et al.]

Elsevier BV ; 2016

In: Cancer Letters Vol. 372, No. 2 ( 2016-03), p. 187-191

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In: Cancer Letters, Elsevier BV, Vol. 372, No. 2 ( 2016-03), p. 187-191

Type of Medium: Online Resource

ISSN: 0304-3835

URL: Article

DOI: 10.1016/j.canlet.2016.01.014

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 195674-7

detail.hit.zdb_id: 2004212-7

SSG: 12

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O‐glycan truncation enhances cancer‐related functions of CD 44 in gastric cancer

Mereiter, Stefan ; Martins, Álvaro M. ; Gomes, Catarina ; [et al.]

Wiley ; 2019

In: FEBS Letters Vol. 593, No. 13 ( 2019-07), p. 1675-1689

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In: FEBS Letters, Wiley, Vol. 593, No. 13 ( 2019-07), p. 1675-1689

Abstract: CD 44 isoforms are often upregulated in gastric cancer and have been associated with increased metastatic potential and poor survival. To evaluate the functional impact of O‐glycan truncation on CD 44 we have analysed glyco‐engineered cancer cell models displaying shortened O‐glycans. Here, we demonstrate that induction of aberrant O‐glycan termination through various molecular mechanisms affects CD 44 molecular features. We show that CD 44 is a major carrier of truncated O‐glycans and that this truncation is accompanied by an increased hyaluronan binding capacity and affects extracellular shedding. In addition, short O‐glycans promoted the colocalization of CD 44v6 with the receptor tyrosine kinase RON and concomitantly increased activation. Our in vitro findings were validated in gastric cancer clinical samples.

Type of Medium: Online Resource

ISSN: 0014-5793 , 1873-3468

URL: Issue

URL: Article

DOI: 10.1002/feb2.2019.593.issue-13

DOI: 10.1002/1873-3468.13432

RVK:

WA 15000

Language: English

Publisher: Wiley

Publication Date: 2019

detail.hit.zdb_id: 1460391-3

SSG: 12

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