X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    The Impact of PRRS Eradication Program on the Production Parameters of the Hungarian Swine Sector
    MDPI AG ; 2023
    In:  Animals Vol. 13, No. 9 ( 2023-05-07), p. 1565-
    Details
    In: Animals, MDPI AG, Vol. 13, No. 9 ( 2023-05-07), p. 1565-
    Abstract: Background: The Hungarian national eradication program of PRRS was successfully completed between 2014 and 2022. There were doubts about the efficiency of the eradication program in Hungary from the beginning to the tune that it might only be carried out efficiently through depopulation–repopulation of the infected herds, which is a very costly procedure. In our study, we investigated the impact of the depopulation–repopulation procedure, which played a prominent role in the PRRS eradication program on the productivity of the Hungarian swine sector–namely, on the number of slaughter pigs per sow per year and the total live slaughter weight per sow per year. Material and Methods: Since 2014, we monitored the evolution of the PRRS eradication through the depopulation–repopulation approach on the large-scale breeding herds in Hungary. Most producers replaced their herds with animals that were free of PRRS and other infectious diseases (mycoplasmosis, actinobacillosis, swine dysentery, atrophic rhinitis, etc.). On this basis, we evaluated the change in the number of slaughter pigs per sow per year as a consequence of depopulation–repopulation of the herds being carried out. In the statistical analysis linear regression was used. Conclusions: The results of our study demonstrate that the PRRS eradication program with the herd depopulation–repopulation approach led to a considerable improvement of the productivity of Hungarian pig farming. This result also demonstrates that, independent of the PRRS eradication, it is still necessary to consider investments into the individual production units to increase efficiency, and to carry out herd depopulation–repopulation in cases where the current genetics limits improvements in productivity.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    URL: Article
    DOI: 10.3390/ani13091565
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2606558-7
    SSG: 23
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 2
    Online Resource
    Online Resource
    Li–Fraumeni-szindróma
    Akademiai Kiado Zrt. ; 2019
    In:  Orvosi Hetilap Vol. 160, No. 6 ( 2019-02), p. 228-234
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 160, No. 6 ( 2019-02), p. 228-234
    Abstract: Abstract: Li-Fraumeni syndrome is a rare genetic disorder predisposing the individual to multiple different cancer types, caused by a germline mutation of the TP53 or CHEK2 genes inherited in an autosomal dominant manner. We hereby describe the case of a family with Li–Fraumeni syndrome. An asymptomatic 40-year-old female was diagnosed with primary lung leiomyosarcoma (T3N0), adenocarcinoma (T1aN0), and inflammatory myofibroblastic tumor, which were surgically removed without further treatment. Twenty months later she underwent surgery for retroperitoneal liposarcoma and even though she received adjuvant chemotherapy, deceased shortly after. Due to family history, the patient underwent TP53 mutation testing, using peripheral blood genomic DNA, which identified a heterozygous, likely pathogenic missense mutation (c.722C 〉 G p.Ser241Cys) in case of the mother and her son. Three years after the patient’s death, her 17-year-old son was diagnosed with a 3.5 cm osteosarcoma of the right second rib, which was surgically removed, followed by adjuvant chemotherapy. However, despite treatment, he deceased after two years. Throughout four generations of the patient’s family, 10 malignant tumors (stomach-, breast-, 2 lung-, and colon cancer, leukemia, leiomyosarcoma, liposarcoma and 2 osteosarcoma) were diagnosed with a mean age of 43.2 (13–70 years) years. The simultaneous appearance of primary lung leiomyosarcoma, inflammatory myofibroblastic tumor and adenocarcinoma in the same organ is extremely rare. When possible, surgical resection should be carried out. Genetic testing for TP53 is recommended when family history is suggestive of Li–Fraumeni syndrome. Prognosis remains poor. Orv Hetil. 2019; 160(6): 228–234.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2019.31290
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2019
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 3
    Online Resource
    Online Resource
    Synthesis, enzyme kinetics and computational evaluation of N-(β-d-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors
    Elsevier BV ; 2013
    In:  Bioorganic & Medicinal Chemistry Vol. 21, No. 18 ( 2013-09), p. 5738-5747
    Details
    In: Bioorganic & Medicinal Chemistry, Elsevier BV, Vol. 21, No. 18 ( 2013-09), p. 5738-5747
    Type of Medium: Online Resource
    ISSN: 0968-0896
    URL: Article
    DOI: 10.1016/j.bmc.2013.07.024
    RVK:
    VA 2619
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 1501507-5
    SSG: 15,3
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 4
    Online Resource
    Online Resource
    Combined use of conventional and clumped carbonate stable isotopes to identify hydrothermal isotopic alteration in cave walls
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-06-02)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-06-02)
    Abstract: Alteration of conventional carbonate stable isotopes (δ 18 O, δ 13 C) in cave walls has been shown to be a useful tool to identify cave formation driven by deep-seated processes, i.e., hypogene karstification. If combined with a prior information on the paleowater stable isotope composition, further insights can be obtained on the temperature and the source of the paleowater. Clumped isotope composition (Δ 47 ) of carbonates is an independent measurement of temperature, and if combined with the conventional stable isotopes, can provide information on the paleowater stable isotope composition. On the example of Provalata Cave (N. Macedonia), we apply for the first time, both conventional and clumped stable isotope analysis, and identify two different isotope alteration trends, reflecting two distinct hydrothermal events: an older, hotter one, where isotope alteration was likely related to isotope diffusion, lowering the δ 18 O values of the carbonate; and a younger one, related to the cave formation by low-temperature CO 2 -rich thermal waters, with dissolution-reprecipitation as the alteration mechanism, causing decrease in δ 18 O values, and unexpected increase in δ 13 C values. The findings are further corroborated by additional insight from optical petrography and cathodoluminescence microscopy, as well as fluid inclusion analysis of secondary calcite crystals related to the cave forming phase.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-12929-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 5
    Online Resource
    Online Resource
    Sampling Strategies in PRRS Elimination in Hungary: An Observational Study Involving Four Farrow-to-Finish Swine Herds
    MDPI AG ; 2023
    In:  Veterinary Sciences Vol. 10, No. 9 ( 2023-08-30), p. 546-
    Details
    In: Veterinary Sciences, MDPI AG, Vol. 10, No. 9 ( 2023-08-30), p. 546-
    Abstract: PRRS elimination strategies often rely on depopulation-repopulation. However, this approach is accompanied by a long-term loss of production. With adequate control measures, such as well-designed immunization programs and technological changes along with prevalence-based laboratory testing, the virus-free status of the most vulnerable age groups in swine herds can be achieved. The most common reason for acquiring PRRSV at large farrow-to-finish swine farm units is that the previously settled fattening pigs serve as a source of infection for the newly reared PRRS-free animals. Following such unwanted events, PRRSV may persist in an affected establishment for several years. In this observational study, we selected four farrow-to-finish type swine herds. We implemented different laboratory testing protocols to find the most optimal solution for a successful PRRS elimination program. To aid our objectives, we used a DIVA PCR technique. The PRRS DIVA PCR assay is a fast, reliable method to identify sows shedding farm-specific PRRSV strain(s). As a result of elimination efforts at the sentinel pig herds, we found that reliable detection of wild-type PRRSV shedding among sows requires sampling at least three weaned piglets per litter. The strict adherence to this sampling protocol, the systematic use of laboratory methods that quickly detect the presence of wild virulent virus in the herd during the rearing period and the culling of DIVA PCR positive litters and their sows decreased the presence of the resident virus markedly. These procedures at Hungarian farrow-to-finish type farms successfully inhibited the wild-type PRRSV infection of different age groups. The results of this study demonstrate that applying this methodology together with strict biosecurity measures enabled us to reach PRRS-vaccinated-free status in large, farrow-to-finish herds within two years.
    Type of Medium: Online Resource
    ISSN: 2306-7381
    URL: Article
    DOI: 10.3390/vetsci10090546
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2768971-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 6
    Online Resource
    Online Resource
    Increased Baseline Proinflammatory Cytokine Production in Chronic Hepatitis C Patients with Rapid Virological Response to Peginterferon Plus Ribavirin
    Public Library of Science (PLoS) ; 2013
    In:  PLoS ONE Vol. 8, No. 7 ( 2013-7-9), p. e67770-
    Details
    In: PLoS ONE, Public Library of Science (PLoS), Vol. 8, No. 7 ( 2013-7-9), p. e67770-
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1371/journal.pone.0067770
    DOI: 10.1371/journal.pone.0067770.g001
    DOI: 10.1371/journal.pone.0067770.g002
    DOI: 10.1371/journal.pone.0067770.g003
    DOI: 10.1371/journal.pone.0067770.g004
    DOI: 10.1371/journal.pone.0067770.g005
    DOI: 10.1371/journal.pone.0067770.t001
    DOI: 10.1371/journal.pone.0067770.t002
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2013
    detail.hit.zdb_id: 2267670-3
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 7
    Online Resource
    Online Resource
    A növényi alapú étrendről
    Akademiai Kiado Zrt. ; 2016
    In:  Orvosi Hetilap Vol. 157, No. 47 ( 2016-11), p. 1859-1865
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 157, No. 47 ( 2016-11), p. 1859-1865
    Abstract: Plant-based diet is an old-new trend in nutrition. In this review based on a historical context, we wish to introduce this popular nutritional trend. Our aim is to present plant-based diet as a primary measure for prevention. We intend to critically analyse some past stereotypes related to plant-based diet – whose main components include fruits, vegetables, whole grains, legumes, nuts and seeds – according to the literature (e.g. protein, vitamin B 12 , folic acid, and iron intake) by doing so we wish to create an adequate conceptual basis for its interpretation. We discuss positive physiological effects of plant-based diet and its possible role in diseases risk reduction. Cardiovascular and metabolic diseases developing due to obesity could be prevented by a properly compiled plant-based diet. For patients with cancer minimizing the intake of foods of animal origin – as opposed to plant-based ones – has proved to have positive effects. Our review suggests this diet can be used in a number of diseases and it also provides long-term sustainable solutions for the health care challenges of the newest era. Orv. Hetil., 2016, 157(47), 1859–1865.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2016.30594
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2016
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 8
    Online Resource
    Online Resource
    Kynurenines and Neurofilament Light Chain in Multiple Sclerosis
    Frontiers Media SA ; 2021
    In:  Frontiers in Neuroscience Vol. 15 ( 2021-5-25)
    Details
    In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 15 ( 2021-5-25)
    Abstract: Multiple sclerosis is an autoimmune, demyelinating, and neurodegenerative disease of the central nervous system. In recent years, it has been proven that the kynurenine system plays a significant role in the development of several nervous system disorders, including multiple sclerosis. Kynurenine pathway metabolites have both neurotoxic and neuroprotective effects. Moreover, the enzymes of the kynurenine pathway play an important role in immunomodulation processes, among others, as well as interacting with neuronal energy balance and various redox reactions. Dysregulation of many of the enzymatic steps in kynurenine pathway and upregulated levels of these metabolites locally in the central nervous system, contribute to the progression of multiple sclerosis pathology. This process can initiate a pathogenic cascade, including microglia activation, glutamate excitotoxicity, chronic oxidative stress or accumulated mitochondrial damage in the axons, that finally disrupt the homeostasis of neurons, leads to destabilization of neuronal cell cytoskeleton, contributes to neuro-axonal damage and neurodegeneration. Neurofilaments are good biomarkers of the neuro-axonal damage and their level reliably indicates the severity of multiple sclerosis and the treatment response. There is increasing evidence that connections exist between the molecules generated in the kynurenine metabolic pathway and the change in neurofilament concentrations. Thus the alterations in the kynurenine pathway may be an important biomarker of the course of multiple sclerosis. In our present review, we report the possible relationship and connection between neurofilaments and the kynurenine system in multiple sclerosis based on the available evidences.
    Type of Medium: Online Resource
    ISSN: 1662-453X
    URL: Article
    DOI: 10.3389/fnins.2021.658202
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2411902-7
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 9
    Online Resource
    Online Resource
    Az élelmiszer-vásárlási szokások változása a Covid járvány alatt Szlovákiában és Magyarországon, helyzetkép Dél-Szlovákiában és Nyugat-Magyarországon
    University of Debrecen/ Debreceni Egyetem ; 2022
    In:  Táplálkozásmarketing Vol. 9, No. 1 ( 2022-06-30), p. 55-70
    Details
    In: Táplálkozásmarketing, University of Debrecen/ Debreceni Egyetem, Vol. 9, No. 1 ( 2022-06-30), p. 55-70
    Abstract: A COVID-19 pandémia megjelenése és gyors terjedése gazdasági sokkhatást okozott, amely változást eredményezett az emberek mindennapi életének szerkezetében, valamint a fogyasztói magatartásban is. A világjárvány, az ebből fakadó korlátozások következtében megváltoztak a fogyasztók munkavégzéssel, kapcsolattartással, étkezéssel, kapcsolatos szokásai. A koronavírus-járvány miatt bevezetett társadalmi távolságtartás az élelmiszer-vásárlási szokások terén is változással járt. Tanulmányunkban megvizsgáltuk, milyen hatással van a COVID-19 két szomszédos ország – Magyarország és Szlovákia két régiójának élelmiszer-vásárlással kapcsolatos fogyasztói magatartására, valamint hogyan változtatta meg az élelmiszervásárlással kapcsolatos döntési tényezőket. Kutatásunk a pandémia második szakaszában, 2020 novemberében kezdődött és 2021 áprilisában fejeződött be. Online kérdőíves felmérést végeztünk levelezőlista, valamint a közösségi média felhasználásával. Hosszú távú trendek vizsgálata ebben a kezdeti időszakban még nem volt lehetséges, így csak a rövid távú hatásokra helyezzük a hangsúlyt. Délnyugat – Szlovákiában, konkrétan a pozsonyi – dunaszerdahelyi – komáromi régióban, Magyarországon pedig a Nyugat - dunántúli régióban (Győr – Moson - Sopron megye) végeztük a felmérést. Több jellegzetesség, magatartási eltérés volt fellelhető a két régió/ország között. Az online élelmiszer-vásárlás olyan általános trend, amely mindkét régióban tapasztalható volt, ezt a pandémiás helyzet némileg tovább fokozta. Kiderült, hogy az online élelmiszervásárlás még nem vált általánosan elterjedtté, a magyar, valamint a szlovák lakosság továbbra is ragaszkodik az élelmiszerek boltban történő vásárlásához. Eredményeink alapján látható, hogy bár nőtt az online vásárlások aránya, mégsem tűnik elegendőnek a válsághelyzet ahhoz, hogy a vásárlókban kialakult rutint, vagy a korlátokat, például az online vásárlással kapcsolatos bizonytalanságot, vagy az új, ezidáig nem ismert termék vásárlását teljesen feloldja. A pozitív tapasztalatokat biztosító változások azonban valószínűleg hosszabb ideig tartanak, különösen azok, amelyek a kényelem és a jólét által vezéreltek, mint például a digitális átvétel, az értékalapú vásárlás és a megnövekedett egészségtudatosság. Ez lehetőséget kínál a vállalatok számára, hogy innovatív, értékalapú és integrált termékeket vagy szolgáltatásokat kínáljanak a vásárlói igények kielégítésére. JEL- kódok: D12, D91
    Type of Medium: Online Resource
    ISSN: 2631-1380 , 2064-8839
    URL: Issue
    URL: Article
    DOI: 10.20494/TM/9/1
    DOI: 10.20494/TM/9/1/5
    Language: Unknown
    Publisher: University of Debrecen/ Debreceni Egyetem
    Publication Date: 2022
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 10
    Online Resource
    Online Resource
    Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund’s adjuvant model of orofacial pain
    Springer Science and Business Media LLC ; 2020
    In:  The Journal of Headache and Pain Vol. 21, No. 1 ( 2020-12)
    Details
    In: The Journal of Headache and Pain, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2020-12)
    Abstract: The neurochemical background of the evolution of headache disorders, still remains partially undiscovered. Accordingly, our aim was to further explore the neurochemical profile of Complete Freund’s adjuvant (CFA)-induced orofacial pain, involving finding the shift point regarding small molecule neurotransmitter concentrations changes vs. that of the previously characterized headache-related neuropeptides. The investigated neurotransmitters consisted of glutamate, γ-aminobutyric acid, noradrenalin and serotonin. Furthermore, in light of its influence on glutamatergic neurotransmission, we measured the level of kynurenic acid (KYNA) and its precursors in the kynurenine (KYN) pathway (KP) of tryptophan metabolism. Methods The effect of CFA was evaluated in male Sprague Dawley rats. Animals were injected with CFA (1 mg/ml, 50 μl/animal) into the right whisker pad. We applied high-performance liquid chromatography to determine the concentrations of the above-mentioned compounds from the trigeminal nucleus caudalis (TNC) and somatosensory cortex (ssCX) of rats. Furthermore, we measured some of these metabolites from the cerebrospinal fluid and plasma as well. Afterwards, we carried out permutation t-tests as post hoc analysis for pairwise comparison. Results Our results demonstrated that 24 h after CFA treatment, the level of glutamate, KYNA and that of its precursor, KYN was still elevated in the TNC, all diminishing by 48 h. In the ssCX, significant concentration increases of KYNA and serotonin were found. Conclusion This is the first study assessing neurotransmitter changes in the TNC and ssCX following CFA treatment, confirming the dominant role of glutamate in early pain processing and a compensatory elevation of KYNA with anti-glutamatergic properties. Furthermore, the current findings draw attention to the limited time interval where medications can target the glutamatergic pathways.
    Type of Medium: Online Resource
    ISSN: 1129-2369 , 1129-2377
    URL: Article
    DOI: 10.1186/s10194-020-01105-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2020168-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages