KOBV Portal

1

Online Resource

Selective Activation of M 4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

Bubser, Michael ; Bridges, Thomas M. ; Dencker, Ditte ; [et al.]

American Chemical Society (ACS) ; 2014

In: ACS Chemical Neuroscience Vol. 5, No. 10 ( 2014-10-15), p. 920-942

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In: ACS Chemical Neuroscience, American Chemical Society (ACS), Vol. 5, No. 10 ( 2014-10-15), p. 920-942

Type of Medium: Online Resource

ISSN: 1948-7193 , 1948-7193

URL: Article

DOI: 10.1021/cn500128b

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2014

detail.hit.zdb_id: 2528493-9

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2

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Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

Wood, Michael R. ; Noetzel, Meredith J. ; Melancon, Bruce J. ; [et al.]

American Chemical Society (ACS) ; 2017

In: ACS Medicinal Chemistry Letters Vol. 8, No. 2 ( 2017-02-09), p. 233-238

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In: ACS Medicinal Chemistry Letters, American Chemical Society (ACS), Vol. 8, No. 2 ( 2017-02-09), p. 233-238

Type of Medium: Online Resource

ISSN: 1948-5875 , 1948-5875

URL: Article

DOI: 10.1021/acsmedchemlett.6b00461

DOI: 10.1021/acsmedchemlett.6b00461.s001

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2017

detail.hit.zdb_id: 2532386-6

SSG: 15,3

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3

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Challenges in the development of an M 4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Wood, Michael R. ; Noetzel, Meredith J. ; Poslusney, Michael S. ; [et al.]

Elsevier BV ; 2017

In: Bioorganic & Medicinal Chemistry Letters Vol. 27, No. 2 ( 2017-01), p. 171-175

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 27, No. 2 ( 2017-01), p. 171-175

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2016.11.086

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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4

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Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: Continued optimization of an MLPCN probe molecule

Melancon, Bruce J. ; Poslusney, Michael S. ; Gentry, Patrick R. ; [et al.]

Elsevier BV ; 2013

In: Bioorganic & Medicinal Chemistry Letters Vol. 23, No. 2 ( 2013-01), p. 412-416

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 23, No. 2 ( 2013-01), p. 412-416

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2012.11.092

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2013

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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5

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Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule

Poslusney, Michael S. ; Melancon, Bruce J. ; Gentry, Patrick R. ; [et al.]

Elsevier BV ; 2013

In: Bioorganic & Medicinal Chemistry Letters Vol. 23, No. 6 ( 2013-3), p. 1860-1864

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 23, No. 6 ( 2013-3), p. 1860-1864

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2013.01.017

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2013

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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6

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Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

Poslusney, Michael S. ; Salovich, James M. ; Wood, Michael R. ; [et al.]

Elsevier BV ; 2019

In: Bioorganic & Medicinal Chemistry Letters Vol. 29, No. 3 ( 2019-02), p. 362-366

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 29, No. 3 ( 2019-02), p. 362-366

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2018.12.039

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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7

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Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists

Poslusney, Michael S. ; Sevel, Christian ; Utley, Thomas J. ; [et al.]

Elsevier BV ; 2012

In: Bioorganic & Medicinal Chemistry Letters Vol. 22, No. 22 ( 2012-11), p. 6923-6928

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 22, No. 22 ( 2012-11), p. 6923-6928

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2012.09.011

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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8

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Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

Harrison, Scott T. ; Poslusney, Michael S. ; Mulhearn, James J. ; [et al.]

American Chemical Society (ACS) ; 2015

In: ACS Medicinal Chemistry Letters Vol. 6, No. 3 ( 2015-03-12), p. 318-323

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In: ACS Medicinal Chemistry Letters, American Chemical Society (ACS), Vol. 6, No. 3 ( 2015-03-12), p. 318-323

Type of Medium: Online Resource

ISSN: 1948-5875 , 1948-5875

URL: Article

DOI: 10.1021/ml500502d

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2015

detail.hit.zdb_id: 2532386-6

SSG: 15,3

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9

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SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs

Chopko, Trevor C. ; Han, Changho ; Gregro, Alison R. ; [et al.]

Elsevier BV ; 2019

In: Bioorganic & Medicinal Chemistry Letters Vol. 29, No. 16 ( 2019-08), p. 2224-2228

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 29, No. 16 ( 2019-08), p. 2224-2228

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2019.06.032

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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10

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Novel Endosomolytic Poly(amido amine) Polymer Conjugates for Systemic Delivery of siRNA to Hepatocytes in Rodents and Nonhuman Primates

Parmar, Rubina Giare ; Poslusney, Micheal ; Busuek, Marina ; [et al.]

American Chemical Society (ACS) ; 2014

In: Bioconjugate Chemistry Vol. 25, No. 5 ( 2014-05-21), p. 896-906

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In: Bioconjugate Chemistry, American Chemical Society (ACS), Vol. 25, No. 5 ( 2014-05-21), p. 896-906

Type of Medium: Online Resource

ISSN: 1043-1802 , 1520-4812

URL: Article

DOI: 10.1021/bc400527e

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2014

detail.hit.zdb_id: 1500067-9

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