In:
Prenatal Diagnosis, Wiley, Vol. 34, No. 6 ( 2014-06), p. 525-533
Abstract:
What's already known about this topic? Previous studies showed an advantage of prenatal low‐resolution microarray analysis over conventional karyotyping in cases with fetal ultrasound abnormalities. A concern was the detection of variants of unknown significance (VOUS). What does this study add? Our study is the first assessing prenatal high‐resolution chromosomal microarray (CMA) and showing the feasibility of this type of analysis in the prenatal setting for any clinical indication. High‐resolution CMA for any clinical indication increases diagnostic yield by at least 17.3% when compared with conventional karyotyping. We do not find an increased rate of VOUS.
Type of Medium:
Online Resource
ISSN:
0197-3851
,
1097-0223
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1491217-X
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