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DataSheet_4.pdf

Jha, Baijayanti ; Reverte, Marta ; Ronet, Catherine ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Cellular and Infection Microbiology Vol. 12 ( 2022-8-12)

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In: Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 12 ( 2022-8-12)

Abstract: The lymphatic system plays a crucial role in mounting immune response against intracellular pathogens, and recent studies have documented its role in facilitating tumor dissemination linked largely with cancer cells. However, in mucocutaneous leishmaniasis (MCL) caused by Leishmania Viannia subgenus showing infectious metastasis and resulting in severe distant secondary lesions, the route of escape of these parasites to secondary sites has not yet been investigated in detail. Our results demonstrated that when infection was associated with inflammation and additionally exacerbated by the presence of dsRNA viral endosymbiont (LRV1), lymphatic vessels could serve as efficient routes for infected cells to egress from the primary site and colonize distant organs. We challenged this hypothesis by using the intracellular Leishmania protozoan parasites Leishmania guyanensis (Lgy) associated with or without a dsRNA viral endosymbiont, exacerbating the infection and responsible for a strong inflammatory response, and favoring metastasis of the infection. We analyzed possible cargo cells and the routes of dissemination through flow cytometry, histological analysis, and in vivo imaging in our metastatic model to show that parasites disseminated not only intracellularly but also as free extracellular parasites using migrating immune cells, lymph nodes (LNs), and lymph vessels, and followed intricate connections of draining and non-draining lymph node to finally end up in the blood and in distant skin, causing new lesions.

Type of Medium: Online Resource

ISSN: 2235-2988

URL: Article

DOI: 10.3389/fcimb.2022.941860

DOI: 10.3389/fcimb.2022.941860.s001

DOI: 10.3389/fcimb.2022.941860.s002

DOI: 10.3389/fcimb.2022.941860.s003

DOI: 10.3389/fcimb.2022.941860.s004

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2619676-1

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Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β

Hartley, Mary-Anne ; Eren, Remzi O. ; Rossi, Matteo ; [et al.]

Shared Science Publishers OG ; 2018

In: Microbial Cell Vol. 5, No. 3 ( 2018-03-05), p. 137-149

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In: Microbial Cell, Shared Science Publishers OG, Vol. 5, No. 3 ( 2018-03-05), p. 137-149

Type of Medium: Online Resource

ISSN: 2311-2638

URL: Issue

URL: Journal

URL: Article

DOI: 10.15698/mic2018.03

DOI: 10.15698/mic

DOI: 10.15698/mic2018.03.619

Language: Unknown

Publisher: Shared Science Publishers OG

Publication Date: 2018

detail.hit.zdb_id: 2814756-X

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TP‐2Rho Is a Sensitive Solvatochromic Red‐Shifted Probe for Monitoring the Interactions between CDK4 and Cyclin D

Pellerano, Morgan ; Naud‐Martin, Delphine ; Peyressatre, Marion ; [et al.]

Wiley ; 2016

In: ChemBioChem Vol. 17, No. 8 ( 2016-04-15), p. 737-744

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In: ChemBioChem, Wiley, Vol. 17, No. 8 ( 2016-04-15), p. 737-744

Abstract: Understanding the intricate steps of protein kinase regulation requires characterization of protein–protein interactions between the catalytic subunit, its regulatory partners and the substrate. Fluorescent probes are useful tools with which to study such interactions and to gain insight into their affinities and specificities. Solvatochromic probes, which display changes in their fluorescence emission in response to changes in the polarity of the medium, are particularly attractive. Here we describe conjugation of a switchable fluorescent dye, TP‐2Rho, to peptide and protein derivatives of cyclin‐dependent kinase 4 (CDK4) and its application to characterization of the interactions between the catalytic subunit of this kinase, its regulatory partner cyclin D1 and a peptide substrate. We demonstrate the sensitivity of TP‐2Rho in relation to of those other dyes used for monitoring peptide–protein and protein–protein interactions. Moreover, we show that TP‐Rho‐labelled peptides can be introduced into living cells to probe endogenous CDK4/cyclin D.

Type of Medium: Online Resource

ISSN: 1439-4227 , 1439-7633

URL: Issue

URL: Article

DOI: 10.1002/cbic.v17.8

DOI: 10.1002/cbic.201500641

RVK:

VA 2918

Language: English

Publisher: Wiley

Publication Date: 2016

detail.hit.zdb_id: 2020469-3

SSG: 12

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Mammalian Innate Immune Response to a Leishmania -Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence

Eren, Remzi Onur ; Reverte, Marta ; Rossi, Matteo ; [et al.]

Elsevier BV ; 2016

In: Cell Host & Microbe Vol. 20, No. 3 ( 2016-09), p. 318-328

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In: Cell Host & Microbe, Elsevier BV, Vol. 20, No. 3 ( 2016-09), p. 318-328

Type of Medium: Online Resource

ISSN: 1931-3128

URL: Article

DOI: 10.1016/j.chom.2016.08.001

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2276339-9

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The β-Carboline Harmine Has a Protective Immunomodulatory Role in Nonhealing Cutaneous Leishmaniasis

Peyvandi, Sanam ; Lan, Qiang ; Chabloz, Antoine ; [et al.]

Elsevier BV ; 2023

In: Journal of Investigative Dermatology ( 2023-10)

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In: Journal of Investigative Dermatology, Elsevier BV, ( 2023-10)

Type of Medium: Online Resource

ISSN: 0022-202X

URL: Article

DOI: 10.1016/j.jid.2023.09.280

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2006902-9

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Detection of Leishmania RNA Virus in Leishmania Parasites

Zangger, Haroun ; Ronet, Catherine ; Desponds, Chantal ; [et al.]

Public Library of Science (PLoS) ; 2013

In: PLoS Neglected Tropical Diseases Vol. 7, No. 1 ( 2013-1-10), p. e2006-

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In: PLoS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 7, No. 1 ( 2013-1-10), p. e2006-

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0002006

DOI: 10.1371/journal.pntd.0002006.g001

DOI: 10.1371/journal.pntd.0002006.g002

DOI: 10.1371/journal.pntd.0002006.g003

DOI: 10.1371/journal.pntd.0002006.g004

DOI: 10.1371/journal.pntd.0002006.g005

DOI: 10.1371/journal.pntd.0002006.g006

DOI: 10.1371/journal.pntd.0002006.g007

DOI: 10.1371/journal.pntd.0002006.g008

DOI: 10.1371/journal.pntd.0002006.t001

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2013

detail.hit.zdb_id: 2429704-5

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The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism

Reverte, Marta ; Eren, Remzi Onur ; Jha, Baijayanti ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Pathogens Vol. 17, No. 3 ( 2021-3-25), p. e1009422-

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In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 3 ( 2021-3-25), p. e1009422-

Abstract: The oxidative burst generated by the host immune system can restrict intracellular parasite entry and growth. While this burst leads to the induction of antioxidative enzymes, the molecular mechanisms and the consequences of this counter-response on the life of intracellular human parasites are largely unknown. The transcription factor NF-E2-related factor (NRF2) could be a key mediator of antioxidant signaling during infection due to the entry of parasites. Here, we showed that NRF2 was strongly upregulated in infection with the human Leishmania protozoan parasites, its activation was dependent on a NADPH oxidase 2 (NOX2) and SRC family of protein tyrosine kinases (SFKs) signaling pathway and it reprogrammed host cell metabolism. In inflammatory leishmaniasis caused by a viral endosymbiont inducing TNF-α in chronic leishmaniasis, NRF2 activation promoted parasite persistence but limited TNF-α production and tissue destruction. These data provided evidence of the dual role of NRF2 in protecting both the invading pathogen from reactive oxygen species and the host from an excess of the TNF-α destructive pro-inflammatory cytokine.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1009422

DOI: 10.1371/journal.ppat.1009422.g001

DOI: 10.1371/journal.ppat.1009422.g002

DOI: 10.1371/journal.ppat.1009422.g003

DOI: 10.1371/journal.ppat.1009422.g004

DOI: 10.1371/journal.ppat.1009422.g005

DOI: 10.1371/journal.ppat.1009422.g006

DOI: 10.1371/journal.ppat.1009422.g007

DOI: 10.1371/journal.ppat.1009422.g008

DOI: 10.1371/journal.ppat.1009422.s001

DOI: 10.1371/journal.ppat.1009422.s002

DOI: 10.1371/journal.ppat.1009422.s003

DOI: 10.1371/journal.ppat.1009422.s004

DOI: 10.1371/journal.ppat.1009422.s005

DOI: 10.1371/journal.ppat.1009422.s006

DOI: 10.1371/journal.ppat.1009422.s007

DOI: 10.1371/journal.ppat.1009422.s008

DOI: 10.1371/journal.ppat.1009422.s009

DOI: 10.1371/journal.ppat.1009422.s010

DOI: 10.1371/journal.ppat.1009422.s011

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2205412-1

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Cohort profile: effect of malaria in early pregnancy on fetal growth in Benin (RECIPAL preconceptional cohort)

Accrombessi, Manfred ; Yovo, Emmanuel ; Cottrell, Gilles ; [et al.]

BMJ ; 2018

In: BMJ Open Vol. 8, No. 1 ( 2018-01), p. e019014-

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In: BMJ Open, BMJ, Vol. 8, No. 1 ( 2018-01), p. e019014-

Abstract: REtard de Croissance Intra-uterin et PALudisme (RECIPAL) is an original preconceptional cohort designed to assess the consequences of malaria during the first trimester of pregnancy, which is a poorly investigated period in Africa and during which malaria may be detrimental to the fetus. Participants For this purpose, a total of 1214 women of reproductive age living in Sô-Ava and Akassato districts (south Benin) were followed up monthly from June 2014 to December 2016 until 411 of them became pregnant. A large range of health determinants was collected both before and during pregnancy from the first weeks of gestation to delivery. Five Doppler ultrasound scans were performed for early dating of the pregnancy and longitudinal fetal growth assessment. Findings to date Pregnant women were identified at a mean of 6.9 weeks of gestation (wg). Preliminary results confirmed the high prevalence of malaria in the first trimester of pregnancy, with more than 25.4% of women presenting at least one microscopic malarial infection during this period. Most infections occurred before six wg. The prevalence of low birth weight, small birth weight for gestational age (according to INTERGROWTH-21st charts) and preterm birth was 9.3%, 18.3% and 12.6%, respectively. Future plans REtard de Croissance Intra-uterin et PALudisme (RECIPAL) represents at this time a unique resource that will provide information on multiple infectious (including malaria), biological, nutritional and environmental determinants in relation to health outcomes in women of reproductive age, pregnant women and their newborns. It will contribute to better define future recommendations for the prevention of malaria in early pregnancy and maternal malnutrition in Africa. It confirms that it is possible to constitute a preconceptional pregnancy cohort in Africa and provides valuable information for researchers starting cohorts in the future.

Type of Medium: Online Resource

ISSN: 2044-6055 , 2044-6055

URL: Article

DOI: 10.1136/bmjopen-2017-019014

DOI: 10.1136/bmjopen-2017-019014.supp1

DOI: 10.1136/bmjopen-2017-019014.supp2

DOI: 10.1136/bmjopen-2017-019014.supp3

DOI: 10.1136/bmjopen-2017-019014.supp4

DOI: 10.1136/bmjopen-2017-019014.supp5

Language: English

Publisher: BMJ

Publication Date: 2018

detail.hit.zdb_id: 2599832-8

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First malaria infections in a cohort of infants in Benin: biological, environmental and genetic determinants. Description of the study site, population methods and preliminary results

Le Port, Agnès ; Cottrell, Gilles ; Martin-Prevel, Yves ; [et al.]

BMJ ; 2012

In: BMJ Open Vol. 2, No. 2 ( 2012), p. e000342-

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In: BMJ Open, BMJ, Vol. 2, No. 2 ( 2012), p. e000342-

Type of Medium: Online Resource

ISSN: 2044-6055 , 2044-6055

URL: Article

DOI: 10.1136/bmjopen-2011-000342

Language: English

Publisher: BMJ

Publication Date: 2012

detail.hit.zdb_id: 2599832-8

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Table_1.xlsx

Snäkä, Tiia ; Bekkar, Amel ; Desponds, Chantal ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Immunology Vol. 13 ( 2022-5-16)

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In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-5-16)

Abstract: Mitochondria regulate steroid hormone synthesis, and in turn sex hormones regulate mitochondrial function for maintaining cellular homeostasis and controlling inflammation. This crosstalk can explain sex differences observed in several pathologies such as in metabolic or inflammatory disorders. Nod-like receptor X1 (NLRX1) is a mitochondria-associated innate receptor that could modulate metabolic functions and attenuates inflammatory responses. Here, we showed that in an infectious model with the human protozoan parasite, Leishmania guyanensis , NLRX1 attenuated inflammation in females but not in male mice. Analysis of infected female and male bone marrow derived macrophages showed both sex- and genotype-specific differences in both inflammatory and metabolic profiles with increased type I interferon production, mitochondrial respiration, and glycolytic rate in Nlrx1 -deficient female BMDMs in comparison to wild-type cells, while no differences were observed between males. Transcriptomics of female and male BMDMs revealed an altered steroid hormone signaling in Nlrx1 -deficient cells, and a “masculinization” of Nlrx1 -deficient female BMDMs. Thus, our findings suggest that NLRX1 prevents uncontrolled inflammation and metabolism in females and therefore may contribute to the sex differences observed in infectious and inflammatory diseases.

Type of Medium: Online Resource

ISSN: 1664-3224

URL: Article

DOI: 10.3389/fimmu.2022.882867

DOI: 10.3389/fimmu.2022.882867.s001

DOI: 10.3389/fimmu.2022.882867.s002

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2606827-8

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