In:
Psychosomatic Medicine, Ovid Technologies (Wolters Kluwer Health)
Abstract:
Mitochondrial dysfunction is implicated in the pathophysiology of psychiatric disorders. Levels of circulating cell-free mitochondrial DNA (cf-mtDNA) are observed to be altered in depression. However, the few studies that have measured cf-mtDNA in depression have reported conflicting findings. This study examined cf-mtDNA and depressive symptoms in low- active adults who smoke. METHODS Participants were adults ages 18-65 years old ( N = 109; 76% female) with low baseline physical activity and depressive symptoms recruited for a smoking cessation study. Self-report measures assessed depression severity, positive and negative affect, and behavioral activation. Blood was collected and analyzed for cf-mtDNA. Relationships between depressive symptoms and cf-mtDNA were examined with correlations and linear regression. RESULTS Levels of cf-mtDNA were associated with categorically-defined depression (Center for Epidemiology Depression Scale (CES-D) score 〉 15), lower positive affect, and decreased behavioral activation ( p 〈 .05). Relationships remained significant after adjustment for age, sex, and nicotine dependence. In a linear regression model including all depressive symptom measures as predictors, CES-D group and lower positive affect remained significant. CONCLUSIONS This work suggests mitochondrial changes are associated with depressive symptoms in low-active adults who smoke. Higher levels of cf-mtDNA in association with depression, and with lower positive affect and decreased behavioral activation, is consistent with a possible role for mitochondrial function in depressive symptomatology.
Type of Medium:
Online Resource
ISSN:
1534-7796
,
0033-3174
DOI:
10.1097/PSY.0000000000001254
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2023
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