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Effective cutaneous vaccination using an inactivated chikungunya virus vaccine delivered by Foroderm

Rudd, Penny A. ; Raphael, Anthony P. ; Yamada, Miko ; [et al.]

Elsevier BV ; 2015

In: Vaccine Vol. 33, No. 39 ( 2015-09), p. 5172-5180

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In: Vaccine, Elsevier BV, Vol. 33, No. 39 ( 2015-09), p. 5172-5180

Type of Medium: Online Resource

ISSN: 0264-410X

URL: Article

DOI: 10.1016/j.vaccine.2015.07.099

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 1468474-3

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Nanopatch‐Targeted Skin Vaccination against West Nile Virus and Chikungunya Virus in Mice

Prow, Tarl W. ; Chen, Xianfeng ; Prow, Natalie A. ; [et al.]

Wiley ; 2010

In: Small Vol. 6, No. 16 ( 2010-08-16), p. 1776-1784

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In: Small, Wiley, Vol. 6, No. 16 ( 2010-08-16), p. 1776-1784

Abstract: The ‘Nanopatch’ (NP) comprises arrays of densely packed projections with a defined geometry and distribution designed to physically target vaccines directly to thousands of epidermal and dermal antigen presenting cells (APCs). These miniaturized arrays are two orders of magnitude smaller than standard needles—which deliver most vaccines—and are also much smaller than current microneedle arrays. The NP is dry‐coated with antigen, adjuvant, and/or DNA payloads. After the NP was pressed onto mouse skin, a protein payload co‐localized with 91.4 ± 4.1 APC mm −2 (or 2925 in total) representing 52% of the delivery sites within the NP contact area, agreeing well with a probability‐based model used to guide the device design; it then substantially increases as the antigen diffuses in the skin to many more cells. APC co‐localizing with protein payloads rapidly disappears from the application area, suggesting APC migration. The NP also delivers DNA payloads leading to cutaneous expression of encoded proteins within 24 h. The efficiency of NP immunization is demonstrated using an inactivated whole chikungunya virus vaccine and a DNA‐delivered attenuated West Nile virus vaccine. The NP thus offers a needle‐free, versatile, highly effective vaccine delivery system that is potentially inexpensive and simple to use.

Type of Medium: Online Resource

ISSN: 1613-6810 , 1613-6829

URL: Issue

URL: Article

DOI: 10.1002/smll.v6:16

DOI: 10.1002/smll.201000331

Language: English

Publisher: Wiley

Publication Date: 2010

detail.hit.zdb_id: 2168935-0

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Vaccine delivery: Nanopatch‐Targeted Skin Vaccination against West Nile Virus and Chikungunya Virus in Mice (Small 16/2010)

Prow, Tarl W. ; Chen, Xianfeng ; Prow, Natalie A. ; [et al.]

Wiley ; 2010

In: Small Vol. 6, No. 16 ( 2010-08-16)

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In: Small, Wiley, Vol. 6, No. 16 ( 2010-08-16)

Type of Medium: Online Resource

ISSN: 1613-6810 , 1613-6829

URL: Issue

URL: Article

DOI: 10.1002/smll.v6:16

DOI: 10.1002/smll.201090052

Language: English

Publisher: Wiley

Publication Date: 2010

detail.hit.zdb_id: 2168935-0

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Virulence and Evolution of West Nile Virus, Australia, 1960–2012

Prow, Natalie A. ; Edmonds, Judith H. ; Williams, David T. ; [et al.]

Centers for Disease Control and Prevention (CDC) ; 2016

In: Emerging Infectious Diseases Vol. 22, No. 8 ( 2016-08), p. 1353-1362

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In: Emerging Infectious Diseases, Centers for Disease Control and Prevention (CDC), Vol. 22, No. 8 ( 2016-08), p. 1353-1362

Type of Medium: Online Resource

ISSN: 1080-6040 , 1080-6059

URL: Article

DOI: 10.3201/eid2208.151719

Language: English

Publisher: Centers for Disease Control and Prevention (CDC)

Publication Date: 2016

detail.hit.zdb_id: 2004375-2

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Viral RNA Intermediates as Targets for Detection and Discovery of Novel and Emerging Mosquito-Borne Viruses

O’Brien, Caitlin A. ; Hobson-Peters, Jody ; Yam, Alice Wei Yee ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS Neglected Tropical Diseases Vol. 9, No. 3 ( 2015-3-23), p. e0003629-

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In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 9, No. 3 ( 2015-3-23), p. e0003629-

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0003629

DOI: 10.1371/journal.pntd.0003629.g001

DOI: 10.1371/journal.pntd.0003629.g002

DOI: 10.1371/journal.pntd.0003629.g003

DOI: 10.1371/journal.pntd.0003629.g004

DOI: 10.1371/journal.pntd.0003629.g005

DOI: 10.1371/journal.pntd.0003629.g006

DOI: 10.1371/journal.pntd.0003629.g007

DOI: 10.1371/journal.pntd.0003629.g008

DOI: 10.1371/journal.pntd.0003629.g009

DOI: 10.1371/journal.pntd.0003629.g010

DOI: 10.1371/journal.pntd.0003629.g011

DOI: 10.1371/journal.pntd.0003629.g012

DOI: 10.1371/journal.pntd.0003629.t001

DOI: 10.1371/journal.pntd.0003629.t002

DOI: 10.1371/journal.pntd.0003629.t003

DOI: 10.1371/journal.pntd.0003629.s001

DOI: 10.1371/journal.pntd.0003629.s002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2429704-5

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Increased expression of capsid protein in trans enhances production of single-round infectious particles by West Nile virus DNA vaccine candidate

Roby, Justin A. ; Bielefeldt-Ohmann, Helle ; Prow, Natalie A. ; [et al.]

Microbiology Society ; 2014

In: Journal of General Virology Vol. 95, No. 10 ( 2014-10-01), p. 2176-2191

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In: Journal of General Virology, Microbiology Society, Vol. 95, No. 10 ( 2014-10-01), p. 2176-2191

Abstract: West Nile virus (WNV; genus Flavivirus , family Flaviviridae ) is an emerging pathogenic arbovirus responsible for outbreaks of encephalitis around the world. Whilst no vaccines are currently available to prevent WNV infection of humans, the use of cDNA copies of flavivirus RNA genomes with large internal deletions within the capsid (C) appears promising. C-deleted vaccines are able to replicate and secrete large amounts of non-infectious immunogenic subviral particles (SVPs) from transfected cells. We have previously generated a WNV DNA vaccine candidate pKUNdC/C where C-deleted WNV cDNA was placed under the control of one copy of the cytomegalovirus (CMV) promoter and the C gene was placed under the control of a second copy of the CMV promoter in the same plasmid DNA. This DNA was shown to generate single-round infectious particles (SRIPs) capable of delivering self-replicating C-deleted RNA producing SVPs to surrounding cells, thus enhancing the vaccine potential. However, the amounts of both SRIPs and SVPs produced from pKUNdC/C DNA were relatively low. In this investigation, we aimed at increasing SRIP production by optimizing trans -C expression via incorporating different forms of C and the use of a more powerful promoter. The construct containing an elongation factor EF1α promoter encoding an extended form of C was demonstrated to produce the highest titres of SRIPs and was immunogenic in mice. Additionally, SRIP and SVP titres were further improved via incorporation of a glycosylation motif in the envelope protein. The optimized DNA yielded ~100-fold greater titres of SRIPs than the original construct, thus providing a promising candidate for further vaccine evaluation.

Type of Medium: Online Resource

ISSN: 0022-1317 , 1465-2099

URL: Article

DOI: 10.1099/vir.0.064121-0

RVK:

XA 53770

RVK:

WA 15000

Language: English

Publisher: Microbiology Society

Publication Date: 2014

detail.hit.zdb_id: 2007065-2

SSG: 12

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Monoclonal antibodies to the West Nile virus NS5 protein map to linear and conformational epitopes in the methyltransferase and polymerase domains

Hall, Roy A. ; Tan, Si En ; Selisko, Barbara ; [et al.]

Microbiology Society ; 2009

In: Journal of General Virology Vol. 90, No. 12 ( 2009-12-01), p. 2912-2922

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In: Journal of General Virology, Microbiology Society, Vol. 90, No. 12 ( 2009-12-01), p. 2912-2922

Abstract: The West Nile virus (WNV) NS5 protein contains a methyltransferase (MTase) domain involved in RNA capping and an RNA-dependent RNA polymerase (RdRp) domain essential for virus replication. Crystal structures of individual WNV MTase and RdRp domains have been solved; however, the structure of full-length NS5 has not been determined. To gain more insight into the structure of NS5 and interactions between the MTase and RdRp domains, we generated a panel of seven monoclonal antibodies (mAbs) to the NS5 protein of WNV (Kunjin strain) and mapped their binding sites using a series of truncated NS5 proteins and synthetic peptides. Binding sites of four mAbs (5D4, 4B6, 5C11 and 6A10) were mapped to residues 354–389 in the fingers subdomain of the RdRp. This is consistent with the ability of these mAbs to inhibit RdRp activity in vitro and suggests that this region represents a potential target for RdRp inhibitors. Using a series of synthetic peptides, we also identified a linear epitope (bound by mAb 5H1) that mapped to a 13 aa stretch surrounding residues 47 and 49 in the MTase domain, a region predicted to interact with the palm subdomain of the RdRp. The failure of one mAb (7G6) to bind both N- and C-terminally truncated NS5 recombinants indicates that the antibody recognizes a conformational epitope that requires the presence of residues in both the MTase and RdRp domains. These data support a structural model of the full-length NS5 molecule that predicts a physical interaction between the MTase and the RdRp domains.

Type of Medium: Online Resource

ISSN: 0022-1317 , 1465-2099

URL: Article

DOI: 10.1099/vir.0.013805-0

RVK:

XA 53770

RVK:

WA 15000

Language: English

Publisher: Microbiology Society

Publication Date: 2009

detail.hit.zdb_id: 2007065-2

SSG: 12

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Infectious Chikungunya Virus in the Saliva of Mice, Monkeys and Humans

Gardner, Joy ; Rudd, Penny A. ; Prow, Natalie A. ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS ONE Vol. 10, No. 10 ( 2015-10-8), p. e0139481-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 10, No. 10 ( 2015-10-8), p. e0139481-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0139481

DOI: 10.1371/journal.pone.0139481.g001

DOI: 10.1371/journal.pone.0139481.g002

DOI: 10.1371/journal.pone.0139481.g003

DOI: 10.1371/journal.pone.0139481.g004

DOI: 10.1371/journal.pone.0139481.t001

DOI: 10.1371/journal.pone.0139481.t002

DOI: 10.1371/journal.pone.0139481.s001

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2267670-3

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Discovery and characterisation of a new insect-specific bunyavirus from Culex mosquitoes captured in northern Australia

Hobson-Peters, Jody ; Warrilow, David ; McLean, Breeanna J ; [et al.]

Elsevier BV ; 2016

In: Virology Vol. 489 ( 2016-02), p. 269-281

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In: Virology, Elsevier BV, Vol. 489 ( 2016-02), p. 269-281

Type of Medium: Online Resource

ISSN: 0042-6822

URL: Article

DOI: 10.1016/j.virol.2015.11.003

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 1471925-3

SSG: 12

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Characterization of Fitzroy River Virus and Serologic Evidence of Human and Animal Infection

Johansen, Cheryl A. ; Williams, Simon H. ; Melville, Lorna F. ; [et al.]

Centers for Disease Control and Prevention (CDC) ; 2017

In: Emerging Infectious Diseases Vol. 23, No. 8 ( 2017-08), p. 1289-1299

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In: Emerging Infectious Diseases, Centers for Disease Control and Prevention (CDC), Vol. 23, No. 8 ( 2017-08), p. 1289-1299

Type of Medium: Online Resource

ISSN: 1080-6040 , 1080-6059

URL: Article

DOI: 10.3201/eid2308.161440

Language: English

Publisher: Centers for Disease Control and Prevention (CDC)

Publication Date: 2017

detail.hit.zdb_id: 2004375-2

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