In:
Immunology & Cell Biology, Wiley, Vol. 96, No. 9 ( 2018-10), p. 981-993
Abstract:
The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class‐I binding. Here, we demonstrate that the immunoproteasome subunit, LMP 2, has functions beyond its immunomodulatory role. Using LMP 2‐deficient mice, we demonstrate that LMP 2 is crucial for lymphocyte development and survival in the periphery. Moreover, LMP 2‐deficient lymphocytes show impaired degradation of key BH 3‐only proteins, resulting in elevated levels of pro‐apoptotic BIM and increased cell death. Interestingly, LMP 2 is the sole immunoproteasome subunit required for BIM degradation. Together, our results suggest LMP 2 has important housekeeping functions and represents a viable therapeutic target for cancer.
Type of Medium:
Online Resource
ISSN:
0818-9641
,
1440-1711
DOI:
10.1111/imcb.2018.96.issue-9
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2011707-3
SSG:
12
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