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  • 1
    Online Resource
    Online Resource
    Neural correlates of fluctuations in the intermediate band for heart rate and respiration are related to interoceptive perception
    Wiley ; 2020
    In:  Psychophysiology Vol. 57, No. 9 ( 2020-09)
    Details
    In: Psychophysiology, Wiley, Vol. 57, No. 9 ( 2020-09)
    Abstract: In addition to the commonly investigated low and high frequency bands of autonomic regulation, an intermediate (IM) band at 0.12–0.18 Hz, considered to reflect psychophysiological states during rest, may be of physiological and clinical interest. Cardiac and respiratory IM band fluctuations correlated with blood oxygen level‐dependent signal fluctuations in the insula and secondary somatosensory cortex and may be related to interoceptive perception.
    Type of Medium: Online Resource
    ISSN: 0048-5772 , 1469-8986
    URL: Issue
    URL: Article
    DOI: 10.1111/psyp.v57.9
    DOI: 10.1111/psyp.13594
    RVK:
    CL 1000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1484299-3
    SSG: 5,2
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  • 2
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    Online Resource
    A Novel Brain–Computer Interface Virtual Environment for Neurofeedback During Functional MRI
    Frontiers Media SA ; 2021
    In:  Frontiers in Neuroscience Vol. 14 ( 2021-1-11)
    Details
    In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 14 ( 2021-1-11)
    Abstract: Virtual environments (VEs), in the recent years, have become more prevalent in neuroscience. These VEs can offer great flexibility, replicability, and control over the presented stimuli in an immersive setting. With recent developments, it has become feasible to achieve higher-quality visuals and VEs at a reasonable investment. Our aim in this project was to develop and implement a novel real-time functional magnetic resonance imaging (rt-fMRI)–based neurofeedback (NF) training paradigm, taking into account new technological advances that allow us to integrate complex stimuli into a visually updated and engaging VE. We built upon and developed a first-person shooter in which the dynamic change of the VE was the feedback variable in the brain–computer interface (BCI). We designed a study to assess the feasibility of the BCI in creating an immersive VE for NF training. In a randomized single-blinded fMRI-based NF-training session, 24 participants were randomly allocated into one of two groups: active and reduced contingency NF. All participants completed three runs of the shooter-game VE lasting 10 min each. Brain activity in a supplementary motor area region of interest regulated the possible movement speed of the player’s avatar and thus increased the reward probability. The gaming performance revealed that the participants were able to actively engage in game tasks and improve across sessions. All 24 participants reported being able to successfully employ NF strategies during the training while performing in-game tasks with significantly higher perceived NF control ratings in the NF group. Spectral analysis showed significant differential effects on brain activity between the groups. Connectivity analysis revealed significant differences, showing a lowered connectivity in the NF group compared to the reduced contingency-NF group. The self-assessment manikin ratings showed an increase in arousal in both groups but failed significance. Arousal has been linked to presence, or feelings of immersion, supporting the VE’s objective. Long paradigms, such as NF in MRI settings, can lead to mental fatigue; therefore, VEs can help overcome such limitations. The rewarding achievements from gaming targets can lead to implicit learning of self-regulation and may broaden the scope of NF applications.
    Type of Medium: Online Resource
    ISSN: 1662-453X
    URL: Article
    DOI: 10.3389/fnins.2020.593854
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2411902-7
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  • 3
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    Online Resource
    Shared network‐level functional alterations across substance use disorders: A multi‐level kernel density meta‐analysis of resting‐state functional connectivity studies
    Wiley ; 2022
    In:  Addiction Biology Vol. 27, No. 4 ( 2022-07)
    Details
    In: Addiction Biology, Wiley, Vol. 27, No. 4 ( 2022-07)
    Abstract: An increasing number of neuroimaging studies indicate functional alterations in cortico‐striatal loops in individuals with substance use disorders (SUD). Dysregulations in these circuits may contribute to drug‐seeking and drug‐consuming behaviour by impeding inhibitory control, habit formation, and reward processing. Despite evidence of network‐level changes in SUD, a shared pattern of functional alterations within and between spatially distributed brain networks has not been systematically investigated. The present meta‐analytic investigation aims at identifying common alterations in resting‐state functional connectivity patterns across different SUD, including stimulant, heroin, alcohol, cannabis, and nicotine use. To this aim, seed‐based whole‐brain connectivity maps for different functional networks were extracted and subjected to multi‐level kernel density analysis to identify dysfunctional networks in individuals with SUD compared with healthy controls. In addition, an exploratory analysis examined substance‐specific effects as well as the influence of drug use status on the main findings. Our findings indicate a hypoconnectivity pattern for the limbic, salience, and frontoparietal networks in individuals with SUD as compared with healthy controls. The default mode network additionally exhibited a complex pattern of hypo‐ and hyperconnectivity across the studies. The observed disrupted connectivity between networks in SUD may associate with deficient inhibitory control mechanisms that are thought to contribute to excessive craving and automatic drug‐related behaviour as well as failure in substance use cessation. The identified network‐based alterations in SUD represent potential treatment targets for neuromodulation, for example, network‐based real‐time functional magnetic resonance imaging (fMRI) neurofeedback. Such interventions can evaluate the behavioural relevance of the identified neural circuits.
    Type of Medium: Online Resource
    ISSN: 1355-6215 , 1369-1600
    URL: Issue
    URL: Article
    DOI: 10.1111/adb.v27.4
    DOI: 10.1111/adb.13200
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1495537-4
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  • 4
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    Online Resource
    Mapping Research Domain Criteria using a transdiagnostic mini-RDoC assessment in mental disorders: a confirmatory factor analysis
    Springer Science and Business Media LLC ; 2023
    In:  European Archives of Psychiatry and Clinical Neuroscience Vol. 273, No. 3 ( 2023-04), p. 527-539
    Details
    In: European Archives of Psychiatry and Clinical Neuroscience, Springer Science and Business Media LLC, Vol. 273, No. 3 ( 2023-04), p. 527-539
    Abstract: This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred and thirty one participants (42.1% suffering from anxiety/fear-related, 18.2% from depressive, 7.9% from schizophrenia spectrum, 7.5% from bipolar, 3.4% from autism spectrum, 2.2% from other disorders, 18.4% healthy controls, and 0.2% with no diagnosis specified) recruited in studies within the German research network for mental disorders for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) were examined with a Mini-RDoC-Assessment including behavioral and self-report measures. The respective data was analyzed with confirmatory factor analysis (CFA) to delineate the underlying latent RDoC-structure. A revised four-factor model reflecting the core domains positive and negative valence systems as well as cognitive systems and social processes showed a good fit across this sample and showed significantly better fit compared to a one factor solution. The connections between the domains PVS, NVS and SP could be substantiated, indicating a universal latent structure spanning across known nosological entities. This study is the first to give an impression on the latent structure and intercorrelations between four core Research Domain Criteria in a transnosological sample. We emphasize the possibility of using already existing and well validated self-report and behavioral measurements to capture aspects of the latent structure informed by the RDoC matrix.
    Type of Medium: Online Resource
    ISSN: 0940-1334 , 1433-8491
    URL: Article
    DOI: 10.1007/s00406-022-01440-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2793981-9
    detail.hit.zdb_id: 1459045-1
    SSG: 2,1
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  • 5
    Online Resource
    Online Resource
    Fronto‐parietal and temporal brain dysfunction in depression: A fMRI investigation of auditory mismatch processing
    Wiley ; 2019
    In:  Human Brain Mapping Vol. 40, No. 12 ( 2019-08-15), p. 3657-3668
    Details
    In: Human Brain Mapping, Wiley, Vol. 40, No. 12 ( 2019-08-15), p. 3657-3668
    Abstract: Mismatch responses reflect neural mechanisms of early cognitive processing in the auditory domain. Disturbances of these mechanisms on multiple levels of neural processing may contribute to clinical symptoms in major depression (MD). A functional magnetic resonance imaging (fMRI) study was conducted to identify neurobiological foundations of altered mismatch processing in MD. Twenty‐five patients with major depression and 25 matched healthy individuals completed an auditory mismatch paradigm optimized for fMRI. Brain activity during mismatch processing was compared between groups. Moreover, seed‐based connectivity analyses investigated depression‐specific brain networks. In patients, mismatch processing was associated with reduced activation in the right auditory cortex as well as in a fronto‐parietal attention network. Moreover, functional coupling between the right auditory cortex and frontal areas was reduced in patients. Seed‐to voxel analysis on the whole‐brain level revealed reduced connectivity between the auditory cortex and the thalamus as well as posterior cingulate. The present study indicates deficits in sensory processing on the level of the auditory cortex in depression. Hyposensitivity in a fronto‐parietal network presumably reflects altered attention mechanisms in depression. The observed impairments may contribute to psychopathology by reducing the ability of the affected individuals to orient attention toward important environmental cues.
    Type of Medium: Online Resource
    ISSN: 1065-9471 , 1097-0193
    URL: Issue
    URL: Article
    DOI: 10.1002/hbm.v40.12
    DOI: 10.1002/hbm.24623
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1492703-2
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  • 6
    Online Resource
    Online Resource
    Auditory neural correlates and neuroergonomics of driving assistance in a simulated virtual environment
    IOP Publishing ; 2023
    In:  Journal of Neural Engineering Vol. 20, No. 4 ( 2023-08-01), p. 046023-
    Details
    In: Journal of Neural Engineering, IOP Publishing, Vol. 20, No. 4 ( 2023-08-01), p. 046023-
    Abstract: Objective. Driver assistance systems play an increasingly important role in modern vehicles. In the current level of technology, the driver must continuously supervise the driving and intervene whenever necessary when using driving assistance systems. The driver’s attentiveness plays an important role in this human–machine interaction. Our aim was to design a simplistic technical framework for studying neural correlates of driving situations in a functional magnetic resonance imaging (fMRI) setting. In this work we assessed the feasibility of our proposed platform. Methods. We proposed a virtual environment (VE) simulation of driver assistance as a framework to investigate brain states related to partially automated driving. We focused on the processing of auditory signals during different driving scenarios as they have been shown to be advantageous as warning stimuli in driving situations. This provided the necessary groundwork to study brain auditory attentional networks under varying environmental demands in an fMRI setting. To this end, we conducted a study with 20 healthy participants to assess the feasibility of the VE simulation. Results. We demonstrated that the proposed VE can elicit driving related brain activation patterns. Relevant driving events evoked, in particular, responses in the bilateral auditory, sensory-motor, visual and insular cortices, which are related to perceptual and behavioral processes during driving assistance. Conceivably, attentional mechanisms increased somatosensory integration and reduced interoception, which are relevant for requesting interactions during partially automated driving. Significance. In modern vehicles, driver assistance technologies are playing an increasingly prevalent role. It is important to study the interaction between these systems and drivers’ attentional responses to aid in future optimizations of the assistance systems. The proposed VE provides a foundational first step in this endeavor. Such simulated VEs provide a safe setting for experimentation with driving behaviors in a semi-naturalistic environment.
    Type of Medium: Online Resource
    ISSN: 1741-2560 , 1741-2552
    URL: Article
    DOI: 10.1088/1741-2552/ace79b
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2135187-9
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    The negative impact of vitamin D on antipsychotic drug exposure may counteract its potential benefits in schizophrenia
    Wiley ; 2022
    In:  British Journal of Clinical Pharmacology Vol. 88, No. 7 ( 2022-07), p. 3193-3200
    Details
    In: British Journal of Clinical Pharmacology, Wiley, Vol. 88, No. 7 ( 2022-07), p. 3193-3200
    Abstract: Patients with schizophrenia frequently show insufficient vitamin D levels, which are associated with somatic comorbidity and may contribute to psychopathology. For many reasons, vitamin D supplementation may be indicated for this patient cohort. However, there is growing evidence for a vitamin D‐mediated increase of drug metabolism by induction of cytochrome P450 (CYP) 3A4. Hence, this study aimed to assess vitamin D's impact on both antipsychotic drug concentrations and psychopathology in a non‐interventional manner. Methods Totals of 107 serum concentrations of different antipsychotic drugs (amisulpride, aripiprazole, clozapine, olanzapine, quetiapine and risperidone), 80 serum concentrations of vitamin D and psychopathological assessments were obtained from 80 patients with schizophrenia. The impact of Vitamin D on antipsychotic drug concentrations and symptomatology was assessed using a generalized linear model, path and correlation analyses. Results We observed a negative relationship between vitamin D and dose‐adjusted antipsychotic drug concentrations, which was particularly pronounced for drugs which are predominantly metabolized via CYP3A4 (i.e., aripiprazole and quetiapine). A path analysis suggested a relieving effect of vitamin D on symptomatology which was, however, counteracted by its negative impact on antipsychotic drug levels. Finally, patients with vitamin D levels above the median exhibited a significantly higher proportion of therapeutically insufficient dose‐normalized drug concentrations of aripiprazole and quetiapine. Conclusion Despite vitamin D's potential benefits on physical and mental health, clinicians should be aware of its negative impact on blood concentrations of antipsychotics metabolized by CYP3A4 in patients with schizophrenia. Therefore, when considering its supplementation, therapeutic drug monitoring should be applied to guide dose adjustment.
    Type of Medium: Online Resource
    ISSN: 0306-5251 , 1365-2125
    URL: Issue
    URL: Article
    DOI: 10.1111/bcp.v88.7
    DOI: 10.1111/bcp.15223
    RVK:
    XA 33650
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1498142-7
    SSG: 15,3
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