In:
Experimental Dermatology, Wiley, Vol. 24, No. 3 ( 2015-03), p. 204-208
Abstract:
The process of sensitisation by specific contact allergens is indispensable for the induction of allergic contact dermatitis. Oxazolone is a well‐characterised contact allergen. Previous studies suggested that immune cells bearing the FcR γ subunit are essential for oxazolone‐induced contact hypersensitivity, but the biological functions of the FcR γ subunit in the process of sensitisation to oxazolone remain unknown. In this study, we show that FcR γ deficiency decreases ear‐swelling responses to oxazolone in mice. However, we found that oxazolone‐sensitised FcR γ −/− mice and oxazolone‐sensitised wild‐type ( WT ) mice have comparable numbers of CD 11c + MHCII hi dendritic cells ( DC s) in their draining lymph nodes ( LN s). In addition, oxazolone‐sensitised LN cells from both FcR γ −/− and WT mice showed considerable production of interferon‐gamma ( IFN γ ), interleukin‐4 ( IL ‐4) and IL ‐17A upon oxazolone‐keyhole limpet haemocyanin loading. Consistent with these data, oxazolone‐sensitised FcR γ −/− and FcR γ +/+ LN cells conferred contact hypersensitivity to WT naïve mice challenged with the hapten. Our findings clearly indicate that, in an experimental mouse model, the FcR γ subunit positively regulates contact hypersensitivity to oxazolone without affecting the contact sensitisation process.
Type of Medium:
Online Resource
ISSN:
0906-6705
,
1600-0625
DOI:
10.1111/exd.2015.24.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2026228-0
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