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1

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The Association of Simultaneous Increase in Interleukin-6, C Reactive Protein, and Matrix Metalloproteinase-9 Serum Levels with Increasing Stages of Colorectal Cancer

Rasic, Ismar ; Rebic, Velma ; Rasic, Azra ; [et al.]

Hindawi Limited ; 2018

In: Journal of Oncology Vol. 2018 ( 2018-07-30), p. 1-7

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In: Journal of Oncology, Hindawi Limited, Vol. 2018 ( 2018-07-30), p. 1-7

Abstract: Background . Tumor development and growth are driven in many cases by inflammatory cells, which can produce cytokines and other factors that can stimulate the development of the malignant process. The aim of this study was to evaluate interleukin-6 (IL-6), C-reactive protein (CRP), matrix metalloproteinase-9 (MMP-9) , serum levels in patients with colorectal cancer (CRC), and their association with the stage of CRC. Methods . IL-6, MMP-9, and CRP serum levels were measured in 75 patients with CRC just before surgical treatment, as well as in 20 healthy individuals as controls. Surgically obtained tissue material was subjected to pathological analysis. Results . Significant increase in CRP and IL-6 serum concentration is associated with increasing stage of CRC ( p 〈 0.05), where MMP-9 serum level was significantly higher in stages III and IV compared to the stage II CRC. Significant correlation was found between IL-6 and MMP-9 serum levels (rho=0.478; p 〈 0.001) as well as between IL-6 and CRP serum levels (rho=0.720; p 〈 0.001) and between MMP-9 and CRP serum levels (rho=0.379; p 〈 0.001). Serum levels of MMP-9 and CRP have been shown to be independent predictors of the CRC stage. Conclusion . Combined quantification of IL-6, MMP-9, and CRP serum levels seems to be a reliable index of inflammation-related processes during colorectal carcinogenesis.

Type of Medium: Online Resource

ISSN: 1687-8450 , 1687-8469

URL: Article

DOI: 10.1155/2018/2830503

Language: English

Publisher: Hindawi Limited

Publication Date: 2018

detail.hit.zdb_id: 2461349-6

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2

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The significance of resistin concentration in metabolical diseases

Rasic, Dragisa ; Stolic, Radojica ; Jovanovic, Aleksandar ; [et al.]

National Library of Serbia ; 2010

In: Military Medical and Pharmaceutical Journal of Serbia Vol. 67, No. 12 ( 2010), p. 965-968

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In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 67, No. 12 ( 2010), p. 965-968

Abstract: Uvod/Cilj. Masno tkivo sekretuje brojne hormonski aktivne supstance koje imaju vaznu ulogu u razvoju razlicitih metabolickih oboljenja. Cilj ove studije bio je da se utvrdi znacaj rezistina kod bolesnika sa razlicitim formama metabolickih bolesti. Metode. Istrazivanje je sprovedeno u bolnici u Lapljem Selu i obuhvatilo je 102 bolesnika koji boluju od diabetes mellitus-a, kardiovaskularnih bolesti i bubrezne insuficijencije, najmanje treceg stepena. Svim ispitanicima obavljena su antropometrijska merenja, kontrolisane osnovne hematoloske i biohemijske analize i koncentracija rezistina. Rezultati. Prosecna starost ispitanika, 69 (67,6%) muskaraca i 33 (32,4%) zena, bila je 55 ? 9,3 godine. Dve trecine nasih bolesnika bili su pusaci. Srednja vrednost sistolnog arterijskog krvnog pritiska bila je 165 ? 17,1 mmHg, a dijastolnog 100 ? 9,23 mmHg, indeks telesne mase bio je u proseku 28,5 ? 3,4 kg/m2, obim kukova 100 ? 10,8 cm, obim struka 110 ? 17,4 cm, a odnos obim kukova/obim struka 1,05 ? 0,14. Vise od jedne trecine ispitanika imalo je neku formu kardiovaskularnih bolesti, bubreznu insuficijenciju imalo je skoro petina bolesnika, dok je diabetes mellitus bio verifikovan kod 44,1% ispitivane populacije. Znacajno vece vrednosti koncentracije rezistina utvrdjene su kod bolesnika sa diabetes mellitusom i bubreznom insuficijencijom. U odnosu na nivo rezistina bolesnici su se, prema broju metabolickih oboljenja po jednom bolesniku, statisticki znacajno razlikovali (F = 11,80; DF = 4,61; p 〈 0,001). Spearmanovom korelacijom (r = 0,66; p 〈 0,001) utvrdjena je statisticki znacajna povezanost izmedju broja bolesti kod jednog ispitanika i nivoa rezistina. Zakljucak. Veci broj manifestnih bolesti po jednom ispitaniku, diabetes mellitus i bubreznu insuficijenciju, karakterisu visoke vrednosti rezistina.

Type of Medium: Online Resource

ISSN: 0042-8450 , 2406-0720

URL: Article

DOI: 10.2298/VSP1012965R

Language: English

Publisher: National Library of Serbia

Publication Date: 2010

detail.hit.zdb_id: 2169819-3

SSG: 15,3

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3

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How frequently does palmoplantar psoriasis affect the palms and/or soles? A systematic review and meta-analysis

Timotijević, Zorica ; Trajković, Goran ; Jankovic, Janko ; [et al.]

Termedia Sp. z.o.o. ; 2019

In: Advances in Dermatology and Allergology Vol. 36, No. 5 ( 2019), p. 595-603

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In: Advances in Dermatology and Allergology, Termedia Sp. z.o.o., Vol. 36, No. 5 ( 2019), p. 595-603

Type of Medium: Online Resource

ISSN: 1642-395X

URL: Article

DOI: 10.5114/ada.2019.89508

Language: Unknown

Publisher: Termedia Sp. z.o.o.

Publication Date: 2019

detail.hit.zdb_id: 2596142-1

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4

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Analysis of health-related biomarkers between vegetarians and non-vegetarians: A multi-biomarker approach

Gajski, Goran ; Gerić, Marko ; Vučić Lovrenčić, Marijana ; [et al.]

Elsevier BV ; 2018

In: Journal of Functional Foods Vol. 48 ( 2018-09), p. 643-653

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In: Journal of Functional Foods, Elsevier BV, Vol. 48 ( 2018-09), p. 643-653

Type of Medium: Online Resource

ISSN: 1756-4646

URL: Article

DOI: 10.1016/j.jff.2018.07.054

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 2467241-5

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5

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Evaluation of Standardized and Applied Variables in predicting Treatment Outcomes of polytrauma patients

Aksamija, Goran ; Mulabdic, Adi ; Rasic, Ismar ; [et al.]

ScopeMed ; 2011

In: Medical Archives Vol. 65, No. 4 ( 2011), p. 233-

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In: Medical Archives, ScopeMed, Vol. 65, No. 4 ( 2011), p. 233-

Type of Medium: Online Resource

ISSN: 0350-199X

URL: Journal

URL: Article

DOI: 10.5455/medarh.

DOI: 10.5455/medarh.2011.65.233-238

Language: Unknown

Publisher: ScopeMed

Publication Date: 2011

detail.hit.zdb_id: 2676157-9

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6

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Coercivity Reduction in Nickel Ferrite (NiFe〈formula formulatype="inline"〉〈tex Notation="TeX"〉$_{2}$〈/tex〉〈/formula〉O 〈formula formulatype="inline"〉〈tex Notation="TeX"〉$_{4}$〈/tex〉〈/formula〉) Thin Films Through Surface Patterning

Rasic, Goran ; Schwartz, Justin

Institute of Electrical and Electronics Engineers (IEEE) ; 2014

In: IEEE Magnetics Letters Vol. 5 ( 2014), p. 1-4

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In: IEEE Magnetics Letters, Institute of Electrical and Electronics Engineers (IEEE), Vol. 5 ( 2014), p. 1-4

Type of Medium: Online Resource

ISSN: 1949-307X , 1949-3088

URL: Article

DOI: 10.1109/LMAG.2014.2302246

Language: Unknown

Publisher: Institute of Electrical and Electronics Engineers (IEEE)

Publication Date: 2014

detail.hit.zdb_id: 2525671-3

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7

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DUV fluorescence bioimaging study of the interaction of partially reduced graphene oxide and liver cancer cells

Dojčilović, Radovan ; Pajović, Jelena D ; Božanić, Dušan K ; [et al.]

IOP Publishing ; 2018

In: 2D Materials Vol. 5, No. 4 ( 2018-08-14), p. 045019-

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In: 2D Materials, IOP Publishing, Vol. 5, No. 4 ( 2018-08-14), p. 045019-

Type of Medium: Online Resource

ISSN: 2053-1583

URL: Article

DOI: 10.1088/2053-1583/aad72b

Language: Unknown

Publisher: IOP Publishing

Publication Date: 2018

detail.hit.zdb_id: 2779376-X

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8

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Joint effect of the SMN2 and SERF1A genes on childhood-onset types of spinal muscular atrophy in Serbian patients

Brkušanin, Miloš ; Kosać, Ana ; Jovanović, Vladimir ; [et al.]

Springer Science and Business Media LLC ; 2015

In: Journal of Human Genetics Vol. 60, No. 11 ( 2015-11), p. 723-728

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In: Journal of Human Genetics, Springer Science and Business Media LLC, Vol. 60, No. 11 ( 2015-11), p. 723-728

Type of Medium: Online Resource

ISSN: 1434-5161 , 1435-232X

URL: Article

DOI: 10.1038/jhg.2015.104

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2015

detail.hit.zdb_id: 1478797-0

SSG: 12

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9

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Nanoimprint lithographic surface patterning of sol–gel fabricated nickel ferrite (NiFe2O4)

Rasic, Goran ; Schwartz, Justin

Springer Science and Business Media LLC ; 2013

In: MRS Communications Vol. 3, No. 4 ( 2013-12), p. 207-211

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In: MRS Communications, Springer Science and Business Media LLC, Vol. 3, No. 4 ( 2013-12), p. 207-211

Type of Medium: Online Resource

ISSN: 2159-6859 , 2159-6867

URL: Article

DOI: 10.1557/mrc.2013.44

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 2645443-9

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10

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Cytotoxic, genotoxic, and oxidative stress-related effects of lysergic acid diethylamide (LSD) and phencyclidine (PCP) in the human neuroblastoma SH-SY5Y cell line

Jurič, Andreja ; Zandona, Antonio ; Lovaković, Blanka Tariba ; [et al.]

Walter de Gruyter GmbH ; 2021

In: Archives of Industrial Hygiene and Toxicology Vol. 72, No. 4 ( 2021-12-01), p. 333-342

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In: Archives of Industrial Hygiene and Toxicology, Walter de Gruyter GmbH, Vol. 72, No. 4 ( 2021-12-01), p. 333-342

Abstract: Lysergic acid diethylamide (LSD) is a classic hallucinogen, widely abused for decades, while phencyclidine (PCP) has increased in popularity in recent years, especially among the adolescents. Very little is known about the general toxicity of these compounds, especially about their possible neurotoxic effects at the cell level. The aim of this study was to address these gaps by assessing the toxic effects of 24-hour exposure to LSD and PCP in the concentration range of 0.39–100 μmol/L in the human neuroblastoma SH-SY5Y cell line. After cell viability was established, cells treated with concentrations that reduced their viability up to 30 % were further subjected to the alkaline comet assay and biochemical assays that enable estimation of oxidative stress-related effects. Treatment with LSD at 6.25 μmol/L and with PCP at 3.13 μmol/L resulted with 88.06±2.05 and 84.17±3.19 % of viable cells, respectively, and led to a significant increase in primary DNA damage compared to negative control. LSD also caused a significant increase in malondialdehyde level, reactive oxygen species (ROS) production, and glutathione (GSH) level, PCP significantly increased ROS but lowered GSH compared to control. Treatment with LSD significantly increased the activities of all antioxidant enzymes, while PCP treatment significantly increased superoxide dismutase (SOD) and glutathione peroxidase (GPx) but decreased catalase (CAT) activity compared to control. Our findings suggest that LSD has a greater DNA damaging potential and stronger oxidative activity than PCP in SH-SY5Y cells.

Type of Medium: Online Resource

ISSN: 1848-6312

URL: Article

DOI: 10.2478/aiht-2021-72-3604

Language: English

Publisher: Walter de Gruyter GmbH

Publication Date: 2021

detail.hit.zdb_id: 2262350-4

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Kooperativer Bibliotheksverbund

Berlin Brandenburg