In:
European Respiratory Journal, European Respiratory Society (ERS), Vol. 60, No. 2 ( 2022-08), p. 2101821-
Abstract:
Cardiorespiratory fitness is not limited by pulmonary mechanical reasons in the majority of adults. However, the degree to which lung function contributes to exercise response patterns among ostensibly healthy individuals remains unclear. Methods We examined 2314 Framingham Heart Study participants who underwent cardiopulmonary exercise testing (CPET) and pulmonary function testing. We investigated the association of forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC and diffusing capacity of the lung for carbon monoxide ( D LCO ) with the primary outcome of peak oxygen uptake ( V ′ O 2 ) along with other CPET parameters using multivariable linear regression. Finally, we investigated the association of total and peripheral pulmonary blood vessel volume with peak V ′ O 2 . Results We found lower FEV 1 , FVC and D LCO were associated with lower peak V ′ O 2 . For example, a 1 L lower FEV 1 and FVC was associated with a 7.1% (95% CI 5.1–9.1%) and 6.0% (95% CI 4.3–7.7%) lower peak V ′ O 2 , respectively. By contrast, FEV 1 /FVC was not associated with peak V ′ O 2 . Lower lung function was associated with lower oxygen uptake efficiency slope, oxygen pulse slope, V ′ O 2 at anaerobic threshold (AT), minute ventilation ( V ′ E ) at AT and breathing reserve. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak V ′ O 2 . Conclusions In a large, community-based cohort of adults, we found lower FEV 1 , FVC and D LCO were associated with lower exercise capacity, as well as oxygen uptake efficiency slope and ventilatory efficiency. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak V ′ O 2 . These findings underscore the importance of lung function and blood vessel volume as contributors to overall exercise capacity.
Type of Medium:
Online Resource
ISSN:
0903-1936
,
1399-3003
DOI:
10.1183/13993003.01821-2021
DOI:
10.1183/13993003.01821-2021.Supp1
DOI:
10.1183/13993003.01821-2021.Shareable1
Language:
English
Publisher:
European Respiratory Society (ERS)
Publication Date:
2022
detail.hit.zdb_id:
2834928-3
detail.hit.zdb_id:
1499101-9
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