In:
Biomedical Research and Therapy, Biomedical Research and Therapy, Vol. 5, No. 1 ( 2018-01-25), p. 1952-1966
Abstract:
Background: Thyroid cancers are common endocrine tumors with diverse medical and histological structures. During development/progression from normal to neoplastic cell, there is a gradual increase in the function/activity of proto-oncogenes, transcription factors and metastasis elements. The main objective of this study is to evaluate per-oxidation of lipid content, total oxidative stress, and the profile of homocysteine (and DNA damage) in the erythrocytes of thyroid carcinoma patients as compared with those of control subjects. Methods: All risk variables and biochemical analyses were quantitatively determined using standard methods. Results: A noteworthy increase in malondialdehyde, globulin, and DNA damage in thyroid carcinoma patients were repeatedly observed. In contrast, healthy individuals showed an increased level of HDL-C and total anti-oxidant response. Conclusion: It is suggested that these parameters have a pivotal role in the diagnostic process of determining thyroid carcinoma patients. Oxidized products of macromolecules in the blood of such patients impart major function in causing thyroid carcinoma disease.
Type of Medium:
Online Resource
ISSN:
2198-4093
,
2198-4093
DOI:
10.15419/bmrat.v5i1.410
Language:
Unknown
Publisher:
Biomedical Research and Therapy
Publication Date:
2018
detail.hit.zdb_id:
2806789-7
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