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Multidrug ATP‐binding cassette transporters are essential for hepatic development of Plasmodium sporozoites

Rijpma, Sanna R. ; Velden, Maarten ; González‐Pons, Maria ; [et al.]

Hindawi Limited ; 2016

In: Cellular Microbiology Vol. 18, No. 3 ( 2016-03), p. 369-383

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In: Cellular Microbiology, Hindawi Limited, Vol. 18, No. 3 ( 2016-03), p. 369-383

Type of Medium: Online Resource

ISSN: 1462-5814 , 1462-5822

URL: Issue

URL: Article

DOI: 10.1111/cmi.v18.3

DOI: 10.1111/cmi.12517

Language: English

Publisher: Hindawi Limited

Publication Date: 2016

detail.hit.zdb_id: 2019990-9

SSG: 12

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Experimentally controlled downregulation of the histone chaperone FACT in Plasmodium berghei reveals that it is critical to male gamete fertility

Laurentino, Eliane C. ; Taylor, Sonya ; Mair, Gunnar R. ; [et al.]

Hindawi Limited ; 2011

In: Cellular Microbiology Vol. 13, No. 12 ( 2011-12), p. 1956-1974

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In: Cellular Microbiology, Hindawi Limited, Vol. 13, No. 12 ( 2011-12), p. 1956-1974

Type of Medium: Online Resource

ISSN: 1462-5814 , 1462-5822

URL: Issue

URL: Article

DOI: 10.1111/cmi.2011.13.issue-12

DOI: 10.1111/j.1462-5822.2011.01683.x

Language: English

Publisher: Hindawi Limited

Publication Date: 2011

detail.hit.zdb_id: 2019990-9

SSG: 12

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Visualisation and Quantitative Analysis of the Rodent Malaria Liver Stage by Real Time Imaging

Ploemen, Ivo H. J. ; Prudêncio, Miguel ; Douradinha, Bruno G. ; [et al.]

Public Library of Science (PLoS) ; 2009

In: PLoS ONE Vol. 4, No. 11 ( 2009-11-18), p. e7881-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 4, No. 11 ( 2009-11-18), p. e7881-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0007881

DOI: 10.1371/journal.pone.0007881.g001

DOI: 10.1371/journal.pone.0007881.g002

DOI: 10.1371/journal.pone.0007881.g003

DOI: 10.1371/journal.pone.0007881.s001

DOI: 10.1371/journal.pone.0007881.s002

DOI: 10.1371/journal.pone.0007881.s003

DOI: 10.1371/journal.pone.0007881.s004

DOI: 10.1371/journal.pone.0007881.s005

DOI: 10.1371/journal.pone.0007881.s006

DOI: 10.1371/journal.pone.0007881.s007

DOI: 10.1371/journal.pone.0007881.s008

DOI: 10.1371/journal.pone.0007881.s009

DOI: 10.1371/journal.pone.0007881.s010

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2009

detail.hit.zdb_id: 2267670-3

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The Plasmodium falciparum male gametocyte protein P230p, a paralog of P230, is vital for ookinete formation and mosquito transmission

Marin-Mogollon, Catherin ; van de Vegte-Bolmer, Marga ; van Gemert, Geert-Jan ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Scientific Reports Vol. 8, No. 1 ( 2018-10-08)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-10-08)

Abstract: Two members of 6-cysteine (6-cys) protein family, P48/45 and P230, are important for gamete fertility in rodent and human malaria parasites and are leading transmission blocking vaccine antigens. Rodent and human parasites encode a paralog of P230, called P230p. While P230 is expressed in male and female parasites, P230p is expressed only in male gametocytes and gametes. In rodent malaria parasites this protein is dispensable throughout the complete life-cycle; however, its function in P . falciparum is unknown. Using CRISPR/Cas9 methodology we disrupted the gene encoding Pfp230p resulting in P . falciparum mutants ( Pf Δ p230p ) lacking P230p expression. The Pf Δ p230p mutants produced normal numbers of male and female gametocytes, which retained expression of P48/45 and P230. Upon activation male PfΔp230p gametocytes undergo exflagellation and form male gametes. However, male gametes are unable to attach to red blood cells resulting in the absence of characteristic exflagellation centres in vitro . In the absence of P230p, zygote formation as well as oocyst and sporozoite development were strongly reduced ( 〉 98%) in mosquitoes. These observations demonstrate that P230p, like P230 and P48/45, has a vital role in P . falciparum male fertility and zygote formation and warrants further investigation as a potential transmission blocking vaccine candidate.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-018-33236-x

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 2615211-3

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Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccine antigens using chimeric rodent parasites

Kolli, Surendra Kumar ; Salman, Ahmed M. ; Ramesar, Jai ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 7 ( 2021-7-12), p. e0254498-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 7 ( 2021-7-12), p. e0254498-

Abstract: To screen for additional vaccine candidate antigens of Plasmodium pre-erythrocytic stages, fourteen P . falciparum proteins were selected based on expression in sporozoites or their role in establishment of hepatocyte infection. For preclinical evaluation of immunogenicity of these proteins in mice, chimeric P . berghei sporozoites were created that express the P . falciparum proteins in sporozoites as an additional copy gene under control of the uis4 gene promoter. All fourteen chimeric parasites produced sporozoites but sporozoites of eight lines failed to establish a liver infection, indicating a negative impact of these P . falciparum proteins on sporozoite infectivity. Immunogenicity of the other six proteins (SPELD, ETRAMP10.3, SIAP2, SPATR, HT, RPL3) was analyzed by immunization of inbred BALB/c and outbred CD-1 mice with viral-vectored (ChAd63 or ChAdOx1, MVA) vaccines, followed by challenge with chimeric sporozoites. Protective immunogenicity was determined by analyzing parasite liver load and prepatent period of blood stage infection after challenge. Of the six proteins only SPELD immunized mice showed partial protection. We discuss both the low protective immunogenicity of these proteins in the chimeric rodent malaria challenge model and the negative effect on P . berghei sporozoite infectivity of several P . falciparum proteins expressed in the chimeric sporozoites.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0254498

DOI: 10.1371/journal.pone.0254498.g001

DOI: 10.1371/journal.pone.0254498.g002

DOI: 10.1371/journal.pone.0254498.g003

DOI: 10.1371/journal.pone.0254498.g004

DOI: 10.1371/journal.pone.0254498.t001

DOI: 10.1371/journal.pone.0254498.s001

DOI: 10.1371/journal.pone.0254498.s002

DOI: 10.1371/journal.pone.0254498.s003

DOI: 10.1371/journal.pone.0254498.s004

DOI: 10.1371/journal.pone.0254498.s005

DOI: 10.1371/journal.pone.0254498.s006

DOI: 10.1371/journal.pone.0254498.s007

DOI: 10.1371/journal.pone.0254498.s008

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2267670-3

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Mini- and micro-satellites in the genome of rodent malaria parasites

van Belkum, Alex ; Ramesar, Jai ; Trommelen, Gerjan ; [et al.]

Elsevier BV ; 1992

In: Gene Vol. 118, No. 1 ( 1992-9), p. 81-86

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In: Gene, Elsevier BV, Vol. 118, No. 1 ( 1992-9), p. 81-86

Type of Medium: Online Resource

ISSN: 0378-1119

URL: Article

DOI: 10.1016/0378-1119(92)90251-J

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 1992

detail.hit.zdb_id: 1491012-3

SSG: 12

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Correction: The Malaria Secretome: From Algorithms to Essential Function in Blood Stage Infection

van Ooij, Christiaan ; Tamez, Pamela ; Bhattacharjee, Souvik ; [et al.]

Public Library of Science (PLoS) ; 2008

In: PLoS Pathogens Vol. 4, No. 6 ( 2008-6-27)

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In: PLoS Pathogens, Public Library of Science (PLoS), Vol. 4, No. 6 ( 2008-6-27)

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/annotation/2b000375-e083-46ed-a44a-ff297e6c37d0

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2008

detail.hit.zdb_id: 2205412-1

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The rodent malaria parasite Plasmodium berghei does not contain a typical O-type small subunit ribosomal RNA gene☆

van Spaendonk, Rosalina M.L ; Ramesar, Jai ; Janse, Chris J ; [et al.]

Elsevier BV ; 2000

In: Molecular and Biochemical Parasitology Vol. 105, No. 1 ( 2000-01-05), p. 169-174

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In: Molecular and Biochemical Parasitology, Elsevier BV, Vol. 105, No. 1 ( 2000-01-05), p. 169-174

Type of Medium: Online Resource

ISSN: 0166-6851

URL: Article

DOI: 10.1016/S0166-6851(99)00175-9

Language: English

Publisher: Elsevier BV

Publication Date: 2000

detail.hit.zdb_id: 1491098-6

SSG: 12

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Structure and expression of a post-transcriptionally regulated malaria gene encoding a surface protein from the sexual stages of Plasmodium berghei

Paton, Michael G. ; Barker, Guy C. ; Matsuoka, Hiroyuki ; [et al.]

Elsevier BV ; 1993

In: Molecular and Biochemical Parasitology Vol. 59, No. 2 ( 1993-6), p. 263-275

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In: Molecular and Biochemical Parasitology, Elsevier BV, Vol. 59, No. 2 ( 1993-6), p. 263-275

Type of Medium: Online Resource

ISSN: 0166-6851

URL: Article

DOI: 10.1016/0166-6851(93)90224-L

Language: English

Publisher: Elsevier BV

Publication Date: 1993

detail.hit.zdb_id: 1491098-6

SSG: 12

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Plasmodium berghei α-tubulin II: A role in both male gamete formation and asexual blood stages

Kooij, Taco W.A. ; Franke-Fayard, Blandine ; Renz, Jasper ; [et al.]

Elsevier BV ; 2005

In: Molecular and Biochemical Parasitology Vol. 144, No. 1 ( 2005-11), p. 16-26

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In: Molecular and Biochemical Parasitology, Elsevier BV, Vol. 144, No. 1 ( 2005-11), p. 16-26

Type of Medium: Online Resource

ISSN: 0166-6851

URL: Article

DOI: 10.1016/j.molbiopara.2005.07.003

Language: English

Publisher: Elsevier BV

Publication Date: 2005

detail.hit.zdb_id: 1491098-6

SSG: 12

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