In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 3 ( 2021-3-10), p. e0248041-
Abstract:
Helicobacter pylori infection does not belong to the spectrum of opportunistic infections in people living with HIV (PLHIV). To evaluate the Helicobacter pylori infection prevalence rate trends in HIV co-infected individuals in comparison to the HIV-negative population, we compared histopathological findings of H . pylori positive gastritis (gastritis topography and histopathology) between 303 PLHIV and 2642 HIV-negative patients who underwent esophagogastroduodenoscopy (EGD) between 1993 and 2014 due to dyspeptic symptoms. The prevalence of H . pylori infection was significantly higher in HIV-negative controls than in PLHIV (50.2% vs. 28.1%). A significantly positive linear trend of H . pylori co-infection in PLHIV was revealed in the observed period (b = 0.030, SE = 0.011, p = 0.013), while this trend was significantly negative in HIV-negative patients (b = - 0.027, SE = 0.003, p 〈 0.001). Patients with HIV/ H . pylori co-infection had significantly higher CD4 + T cell counts and more often had undetectable HIV viremia, due to successful anti-retroviral therapy (ART). Stomach histopathological findings differed between HIV co-infected and H . pylori mono-infected patients. Our findings confirm that the ART has changed the progression of HIV infection, leading to a significant increase in the prevalence of H . pylori infection in dyspeptic PLHIV over time. Our data also suggests that a functional immune system may be needed for H . pylori -induced human gastric mucosa inflammation.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0248041
DOI:
10.1371/journal.pone.0248041.g001
DOI:
10.1371/journal.pone.0248041.t001
DOI:
10.1371/journal.pone.0248041.t002
DOI:
10.1371/journal.pone.0248041.t003
DOI:
10.1371/journal.pone.0248041.t004
DOI:
10.1371/journal.pone.0248041.t005
DOI:
10.1371/journal.pone.0248041.s001
DOI:
10.1371/journal.pone.0248041.s002
DOI:
10.1371/journal.pone.0248041.s003
DOI:
10.1371/journal.pone.0248041.s004
DOI:
10.1371/journal.pone.0248041.s005
DOI:
10.1371/journal.pone.0248041.s006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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