In:
Asian Journal of Chemistry, Asian Journal of Chemistry, Vol. 34, No. 3 ( 2022), p. 627-634
Abstract:
A facile one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (4a-h) was performed in the presence of sulphonated reduced graphene
oxide nanoparticles (SrGO NPs), using various substituted aromatic aldehydes (1a-h), β-keto ester (2) and urea (3). Methanol solvent mediated the reaction, under refluxing conditions. The synthesized SrGO NPs were characterized using XRD, SEM-EDS and Raman
spectroscopic methods. The structural moieties of the organic compounds were confirmed by 1H NMR, 13C NMR, FTIR and Mass spectroscopic techniques. The in vitro anticancer activity of the synthesized derivatives (4a-h) was investigated using MTT (4,5-
dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) colorimetric assay as per American Type Culture Collection protocol. The cytotoxic studies were conducted against MCF-7, SKNSH human cells, using doxorubicin as the standard. Majority of the derivatives have exhibited
superior anticancer activity.
Type of Medium:
Online Resource
ISSN:
0975-427X
,
0970-7077
DOI:
10.14233/ajchem.2022.23543
Language:
English
Publisher:
Asian Journal of Chemistry
Publication Date:
2022
detail.hit.zdb_id:
3140213-6
Bookmarklink