In:
Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 40, No. 4 ( 1990-04), p. 707-707
Abstract:
We found blood pressure (BP), heart rate (HR), plasma norepinephrine (NE), and epinephrine (E) levels in the lying and the standing positions to be similar in never-treated parkinsonian patients (stages 1 and 2) and age-matched controls. CY 208-243, a new centrally active D 1 agonist, significantly decreased BP, HR, and NE (but not E) values in the lying position; it elicited orthostatic hypotension and blunted the rise in NE elicited by standing up. These results indicate that the early stages of Parkinson's disease are not accompanied by major changes in autonomie cardiovascular function and suggest the involvement of central D 1 -receptors in the control of sympathetic tone.
Type of Medium:
Online Resource
ISSN:
0028-3878
,
1526-632X
DOI:
10.1212/WNL.40.4.707
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
1990
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