In:
International Journal of Cancer, Wiley, Vol. 145, No. 3 ( 2019-08), p. 678-685
Abstract:
What's new? While serum biomarkers are ideal tools for colorectal cancer (CRC) detection, the identification of a marker with both high sensitivity and high specificity has proven challenging. Here, the authors investigated β 6 ‐integrin (ITGB6), a molecule upregulated in association with epithelial‐to‐mesenchymal transition activities, such as wound healing and carcinogenesis, for its biomarker potential in CRC. In patients, ITGB6 serum levels were significantly associated with CRC diagnosis and prognosis. A cut‐off of ≥2 ng/mL ITGB6 reliably predicted metastatic disease and poor CRC prognosis. The findings suggest that employing ITGB6 as a serum biomarker could greatly aid diagnosis and tumor surveillance in CRC patients.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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