In:
Neurodegenerative Diseases, S. Karger AG, Vol. 22, No. 2 ( 2022), p. 83-86
Abstract:
〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 This study aimed at testing whether CSF levels of amyloid β 〈 sub 〉 42 〈 /sub 〉 (Aβ 〈 sub 〉 42 〈 /sub 〉 ), Aβ 〈 sub 〉 40 〈 /sub 〉 , total tau, and phosphorylated tau (P-tau 〈 sub 〉 181 〈 /sub 〉 ) individually contribute to the identification of atypical phenotypes among a retrospective cohort of probable Alzheimer’s disease (AD) patients diagnosed by means of the ratio between Aβ 〈 sub 〉 42 〈 /sub 〉 and Aβ 〈 sub 〉 40 〈 /sub 〉 (Aβ 〈 sub 〉 42/40 〈 /sub 〉 ). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The retrospective study cohort comprised 50 probable AD patients diagnosed by means of the ratio between Aβ 〈 sub 〉 42 〈 /sub 〉 and Aβ 〈 sub 〉 40 〈 /sub 〉 (Aβ 〈 sub 〉 42/40 〈 /sub 〉 ) and for whom total tau and P-tau 〈 sub 〉 181 〈 /sub 〉 values were also available. Patients were clinically classified as typical, amnestic-predominant AD ( 〈 i 〉 N 〈 /i 〉 = 39; 16 males; mean age: 73.4 ± 7.6 years; mean disease duration: 27.4 ± 24.7 months), or atypical phenotypes ( 〈 i 〉 N 〈 /i 〉 = 11; 6 males; mean age: 70.2 ± 6.5 years; mean disease duration: 35.5 ± 24.9 months) – i.e., posterior cortical atrophy ( 〈 i 〉 N 〈 /i 〉 = 4), logopenic-variant primary progressive aphasia ( 〈 i 〉 N 〈 /i 〉 = 4), and behavioural variant AD ( 〈 i 〉 N 〈 /i 〉 = 3). A logistic regression allowed predicting the occurrence of atypical versus typical phenotypes based on age, sex, and Aβ 〈 sub 〉 42 〈 /sub 〉 , Aβ 〈 sub 〉 40 〈 /sub 〉 , total tau, and P-tau 〈 sub 〉 181 〈 /sub 〉 levels. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Atypical and typical AD patients were comparable for Aβ 〈 sub 〉 42/40 〈 /sub 〉 values. Only Aβ 〈 sub 〉 40 〈 /sub 〉 and P-tau 〈 sub 〉 181 〈 /sub 〉 levels positively ( 〈 i 〉 p 〈 /i 〉 = 0.015) and negatively ( 〈 i 〉 p 〈 /i 〉 = 0.019) predicted the occurrence of atypical AD phenotypes, respectively. Classification precision was of 86%, yielding excellent specificity (94.9%) but poor sensitivity (54.5%). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The present study delivers promising, albeit preliminary, evidence on the utility of Aβ 〈 sub 〉 40 〈 /sub 〉 and P-tau 〈 sub 〉 181 〈 /sub 〉 CSF biomarkers in differentiating atypical from typical Aβ 〈 sub 〉 42/40 〈 /sub 〉 -confirmed AD phenotypes, prompting further research and confirmation on larger cohorts.
Type of Medium:
Online Resource
ISSN:
1660-2854
,
1660-2862
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
2126858-7
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