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  • 1
    Online Resource
    Online Resource
    supp1-3192144.pdf
    Institute of Electrical and Electronics Engineers (IEEE) ; 2023
    In:  IEEE Transactions on Biomedical Engineering Vol. 70, No. 1 ( 2023-1), p. 390-398
    Details
    In: IEEE Transactions on Biomedical Engineering, Institute of Electrical and Electronics Engineers (IEEE), Vol. 70, No. 1 ( 2023-1), p. 390-398
    Type of Medium: Online Resource
    ISSN: 0018-9294 , 1558-2531
    URL: Article
    URL: Article
    DOI: 10.1109/TBME.2022.3192144
    DOI: 10.1109/TBME.2022.3192144/mm1
    RVK:
    XA 48665
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2023
    detail.hit.zdb_id: 2021742-0
    detail.hit.zdb_id: 2571926-9
    detail.hit.zdb_id: 2561637-7
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  • 2
    Online Resource
    Online Resource
    Long-Term Antibody Response to SARS-CoV-2 in Children
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Clinical Immunology Vol. 43, No. 1 ( 2023-01), p. 46-56
    Details
    In: Journal of Clinical Immunology, Springer Science and Business Media LLC, Vol. 43, No. 1 ( 2023-01), p. 46-56
    Abstract: Almost 2 years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID-19 Child Health Investigation of Latent Disease) Study is a prospective cohort study designed to identify and follow up children and their household contacts infected in the early 2020 first wave of SARS-CoV-2. We screened 6113 children  〈  18 years by nasopharyngeal swab-PCR in a low-incidence setting after general lockdown, from May 11 to June 30, 2020. A total of 4657 participants underwent antibody testing. Positive tests were followed up by repeated PCR and serological testing of all household contacts over 6 months. In total, the study identified 67 seropositive children (1.44%); the median time after infection at first presentation was 83 days post-symptom onset (PSO). Follow-up of household contacts showed less than 100% seroprevalence in most families, with higher seroprevalence in families with adult index cases compared to pediatric index cases (OR 1.79, P  = 0.047). Most importantly, children showed sustained seroconversion up to 9 months PSO, and serum antibody concentrations persistently surpassed adult levels (ratio serum IgG spike children vs. adults 90 days PSO 1.75, P   〈  0.001; 180 days 1.38, P  = 0.01; 270 days 1.54, P  = 0.001). In a low-incidence setting, SARS-CoV-2 infection and humoral immune response present distinct patterns in children including higher antibody levels, and lower seroprevalence in families with pediatric index cases. Children show long-term SARS-CoV-2 antibody responses. These findings are relevant to novel variants with increased disease burden in children, as well as for the planning of age-appropriate vaccination strategies.
    Type of Medium: Online Resource
    ISSN: 0271-9142 , 1573-2592
    URL: Article
    DOI: 10.1007/s10875-022-01355-w
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2016755-6
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  • 3
    Online Resource
    Online Resource
    Accuracy of computer-aided geometric 3D reconstruction based on histological serial microgrinding preparation
    Informa UK Limited ; 2011
    In:  Computer Methods in Biomechanics and Biomedical Engineering Vol. 14, No. 7 ( 2011-07), p. 581-594
    Details
    In: Computer Methods in Biomechanics and Biomedical Engineering, Informa UK Limited, Vol. 14, No. 7 ( 2011-07), p. 581-594
    Type of Medium: Online Resource
    ISSN: 1025-5842 , 1476-8259
    URL: Article
    DOI: 10.1080/10255842.2010.487049
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2011
    detail.hit.zdb_id: 2049175-X
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  • 4
    Online Resource
    Online Resource
    The Use of Clinically Measurable Cochlear Parameters in Cochlear Implant Surgery as Indicators for Size, Shape, and Orientation of the Scala Tympani
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Ear & Hearing Vol. 42, No. 4 ( 2021-07), p. 1034-1041
    Details
    In: Ear & Hearing, Ovid Technologies (Wolters Kluwer Health), Vol. 42, No. 4 ( 2021-07), p. 1034-1041
    Abstract: (1) To assess variations of the human intracochlear anatomy and quantify factors which might be relevant for cochlear implantation (CI) regarding surgical technique and electrode design. (2) Search for correlations of these factors with clinically assessable measurements. Design: Human temporal bone study with micro computed tomography (μCT) data and analysis of intracochlear geometrical variations: μCT data of 15 fresh human temporal bones was generated, and the intracochlear lumina scala tympani (ST) and scala vestibuli were manually segmented using custom software specifically designed for accurate cochlear segmentation. The corresponding datasets were processed yielding 15 detailed, three-dimensional cochlear models which were investigated in terms of the scalae height, cross-sectional size, and rotation as well as the interrelation of these factors and correlations to others. Results: The greatest anatomical variability was observed within the round window region of the cochlea (basal 45°), especially regarding the cross-sectional size of the ST and its orientation relative to the scala vestibuli, which were found to be correlated ( p 〈 0.001). The cross-sectional height of the ST changes substantially for both increasing cochlear angles and lateral wall distances. Even small cochleae were found to contain enough space for all commercially available CI arrays. Significant correlations of individual intracochlear parameters to clinically assessable ones were found despite the small sample size. Conclusion: While there is generally enough space within the ST for CI, strong intracochlear anatomical variations could be observed highlighting the relevance of both soft surgical technique as well as a highly flexible and self-adapting cochlear implant electrode array design. Cochlear dimensions (especially at the round window) could potentially be used to indicate surgically challenging anatomies.
    Type of Medium: Online Resource
    ISSN: 1538-4667
    URL: Article
    DOI: 10.1097/AUD.0000000000000998
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2081799-X
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  • 5
    Online Resource
    Online Resource
    Minimally invasive mastoidectomy approach using a mouldable surgical targeting system
    Walter de Gruyter GmbH ; 2018
    In:  Current Directions in Biomedical Engineering Vol. 4, No. 1 ( 2018-09-01), p. 403-406
    Details
    In: Current Directions in Biomedical Engineering, Walter de Gruyter GmbH, Vol. 4, No. 1 ( 2018-09-01), p. 403-406
    Abstract: Hearing restoration using a cochlear implant requires a surgical access to the inner ear. In order to enhance patient safety, reduce trauma, and shorten the patient’s time under anaesthesia current research focusses on minimally invasive cochlear implantation surgery by drilling only a single bore hole. This demands a highly accurate surgical assistance device to guide the drill along a predetermined trajectory planned in patient’s image data. In this study a recently developed surgical targeting system was evaluated for the first time in a human cadaver trial. After screwing a reference frame on a temporal bone specimen and imaging of both, a trajectory through the facial recess was planned in order to reach the middle ear. Based on this plan a patient specific surgical template including a linear guide for the surgical drill was composed utilizing bone cement. After the hardening of the bone cement the surgical template was mounted on top of the reference frame. The drilling could be performed as previously planned without harming facial nerve and chorda tympani. The deviation of the actual drill hole to the planned trajectory was 0.17 mm at the level of the facial recess. The minimal distance of the drill hole to the facial nerve was 0.59 mm. This proof-of-concept study demonstrates the feasibility of performing the access to the middle ear in a minimally invasive manner using the mouldable surgical targeting system. The presented process allows the patient specific individualization of a drill guide under sterile conditions. This might facilitate its integration into clinical routine.
    Type of Medium: Online Resource
    ISSN: 2364-5504
    URL: Article
    DOI: 10.1515/cdbme-2018-0096
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2018
    detail.hit.zdb_id: 2835398-5
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  • 6
    Online Resource
    Online Resource
    A Tool to Enable Intraoperative Insertion Force Measurements for Cochlear Implant Surgery
    Institute of Electrical and Electronics Engineers (IEEE) ; 2023
    In:  IEEE Transactions on Biomedical Engineering Vol. 70, No. 5 ( 2023-5), p. 1643-1650
    Details
    In: IEEE Transactions on Biomedical Engineering, Institute of Electrical and Electronics Engineers (IEEE), Vol. 70, No. 5 ( 2023-5), p. 1643-1650
    Type of Medium: Online Resource
    ISSN: 0018-9294 , 1558-2531
    URL: Article
    DOI: 10.1109/TBME.2022.3224528
    RVK:
    XA 48665
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2023
    detail.hit.zdb_id: 2021742-0
    detail.hit.zdb_id: 2571926-9
    detail.hit.zdb_id: 2561637-7
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  • 7
    Online Resource
    Online Resource
    Toward steerable electrodes. An overview of concepts and current research.
    Walter de Gruyter GmbH ; 2017
    In:  Current Directions in Biomedical Engineering Vol. 3, No. 2 ( 2017-09-26), p. 765-769
    Details
    In: Current Directions in Biomedical Engineering, Walter de Gruyter GmbH, Vol. 3, No. 2 ( 2017-09-26), p. 765-769
    Abstract: Restoration of hearing is a demanding surgical task which requires the insertion of a cochlear implant electrode array into the inner ear while preserving the delicate basilar membrane inside the cochlea for an atraumatic insertion. Already shortly after the first clinical success with early versions of cochlear implants the desire for a controlled insertion of the electrode array arose. Such a steerable electrode should be in its shape adaptable to the individual path of the helical inner ear in order to avoid any contact between the implant and the surrounding tissue. This article provides a short overview of concepts and actuator mechanisms investigated in the past and present with the objective of developing a steerable electrode array for an individualized insertion process. Although none of these concepts has reached clinical implementation, there are promising experimental results indicating that insertion forces can be reduced up to 60% compared to straight and not steerable electrodes. Finally, related research topics are listed which require considerable further improvements until steerable electrodes will reach clinical applicability.
    Type of Medium: Online Resource
    ISSN: 2364-5504
    URL: Article
    DOI: 10.1515/cdbme-2017-0161
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2017
    detail.hit.zdb_id: 2835398-5
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  • 8
    Online Resource
    Online Resource
    Impact of anatomical variations on insertion forces
    Walter de Gruyter GmbH ; 2018
    In:  Current Directions in Biomedical Engineering Vol. 4, No. 1 ( 2018-09-01), p. 509-512
    Details
    In: Current Directions in Biomedical Engineering, Walter de Gruyter GmbH, Vol. 4, No. 1 ( 2018-09-01), p. 509-512
    Abstract: The choice of a cochlear implant electrode carrier for the individual patient is influenced by cochlear size, as this parameter has an impact on the risk of scala dislocations. Therefore, size and morphology should be represented in artificial cochlear models too, since these are generally used for insertion studies evaluating newly developed cochlear implant electrode carriers and insertion techniques, before human temporal bone studies are applied for. Within this study custom-made electrode carrier test samples were inserted into nine artificial cochlear models of different shape. To fabricate them, four human temporal bone samples have been processed by a serial cross-sectioning technique; the other four samples have been scanned with micro computed tomography. The cochlea was segmented on this data using rotating, midmodiolar slice planes, followed by the generation of a three-dimensional digital model, which finally was projected on a plane and 2D models were milled out of PTFE. The ratios of length to width of the cochlear basal turn of our samples were found to be within previously reported range. For comparative reasons a model used in previous studies was included in this study too. The maximal insertion forces per cochlear model followed a normal distribution. The insertion depth at initial insertion force increase is correlated to the length of cochlear basal turn. Using the here presented cochlear models with varying anatomical measures may help to increase the clinical relevance of insertion studies in artificial cochlear models.
    Type of Medium: Online Resource
    ISSN: 2364-5504
    URL: Article
    DOI: 10.1515/cdbme-2018-0122
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2018
    detail.hit.zdb_id: 2835398-5
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  • 9
    Online Resource
    Online Resource
    Identification of factors influencing insertion characteristics of cochlear implant electrode carriers
    Walter de Gruyter GmbH ; 2019
    In:  Current Directions in Biomedical Engineering Vol. 5, No. 1 ( 2019-09-01), p. 441-443
    Details
    In: Current Directions in Biomedical Engineering, Walter de Gruyter GmbH, Vol. 5, No. 1 ( 2019-09-01), p. 441-443
    Abstract: Insertion studies in artificial cochlea models (aCM) are used for the analysis of insertion characteristics of different cochlear implant electrode carrier (EC) designs by measuring insertion forces. These forces are summed forces due to the measuring position which is directly underneath the aCM. The current hypothesis is that they include dynamic friction forces during the insertion process and the forces needed to bend an initially straight EC into the curved form of the aCM. For the purposes of the present study, straight EC substitutes with a constant diameter of 0.7 mm and 20.5 mm intracochlear length were fabricated out of silicone in two versions with different stiffness by varying the number of embedded wires. The EC substitutes were inserted into three different models made of polytetrafluoroethylene (PTFE), each model showing only one constant radius. Three different insertion speeds were used (0.11 / 0.4 / 1.6 mm/s) with an automated insertion test bench. For each parameter combination (curvature, speed, stiffness) twelve insertions were conducted. Measurements included six full insertions and six paused insertions. Paused insertions include a ten second paused time interval without further insertion movement each five millimetres. Measurements showed that dynamic and static components of the measured summed forces can be identified. Dynamic force components increase with increased insertion speeds and also with increased stiffness of the EC substitutes. Both force components decrease with larger radius of the PTFE model. After the insertion, the EC substitutes showed a curved shape, which indicates a plastic deformation of the embedded wires due to the insertion into the curved models. The results can be used for further research on an analytical model to predict the insertions forces of a specific combination of selected parameters as insertion speed and type of EC, combined with given factors such as cochlear geometry.
    Type of Medium: Online Resource
    ISSN: 2364-5504
    URL: Article
    DOI: 10.1515/cdbme-2019-0111
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2019
    detail.hit.zdb_id: 2835398-5
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  • 10
    Online Resource
    Online Resource
    Toward a cochlear implant electrode array with shape memory effect for post‐insertion perimodiolar positioning
    Wiley ; 2022
    In:  Journal of Biomedical Materials Research Part B: Applied Biomaterials Vol. 110, No. 11 ( 2022-11), p. 2494-2505
    Details
    In: Journal of Biomedical Materials Research Part B: Applied Biomaterials, Wiley, Vol. 110, No. 11 ( 2022-11), p. 2494-2505
    Abstract: For cochlear implants (CI) a final position of the electrode array (EA) along the inner wall of the spirally shaped cochlea is considered to be beneficial because it results in a closer proximity to the auditory nerve fibers. A shape memory effect (SME) could facilitate such shift of the EA toward the cochlear inner wall, but its implementation remains to be solved. The current study presents an EA prototype featuring the SME with minute adjustments of the material properties of Nitinol, a shape memory alloy, in combination with a suitable cooling strategy to prevent premature curling. Ten samples were successfully inserted by a CI surgeon into an artificial cochlear model submerged into a temperature‐controllable water bath to simulate temporary hypothermia of the inner ear (31°C). Gentle insertions were possible, with an average insertion speed of 0.81 ± 0.14 mm/s. After recovery of body temperature, the desired position shift toward the modiolus was observed in all trials. Angular insertion depth increased by approximately 81.8° ± 23.4°. We demonstrate for the first time that using the body temperature responsive SME for perimodiolar EA positioning is feasible and does not impede a gentle surgical insertion.
    Type of Medium: Online Resource
    ISSN: 1552-4973 , 1552-4981
    URL: Issue
    URL: Article
    DOI: 10.1002/jbm.b.v110.11
    DOI: 10.1002/jbm.b.35107
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2130917-6
    SSG: 12
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