In:
Journal of Applied Toxicology, Wiley, Vol. 35, No. 4 ( 2015-04), p. 418-425
Abstract:
A method consisting of dispersive liquid–liquid microextraction and high‐performance liquid chromatography with photodiode array detection (DLLME/HPLC‐PDA) was used to determine morphine, 6‐acetylmorphine, cocaine, benzoylecgonine and methadone in human plasma. An experimental design based on a Uniform Network Doehlert allowed the optimization of the extraction conditions. The chromatographic method was validated assessing linearity, limits of detection and quantitation, selectivity, precision and accuracy. Finally, the proposed method was successfully applied to 22 plasma samples from drug users.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1475015-6
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