In:
Chemistry & Biodiversity, Wiley, Vol. 5, No. 10 ( 2008-10), p. 2160-2170
Abstract:
Two platinum(IV) complexes ( OC ‐6‐33)‐dichlorido(ethane‐1,2‐diamine)dihydroxidoplatinum( IV ) and ( OC ‐6‐33)‐diammine(dichlorido)dihydroxidoplatinum( IV ) were carboxylated using demethylcantharidin as carboxylation agent. The complexes were characterized by elemental analysis, mass spectrometry, multinuclear ( 1 H, 13 C, 15 N, and 195 Pt) NMR spectroscopy, and, in case of ( OC ‐6‐33)‐diamminebis(3‐carboxy‐7 exo ‐oxabicyclo[2.2.1]heptane‐2‐carboxylato)dichloridoplatinum(IV) via X‐ray diffraction. Cytotoxicity of the complexes was studied in seven human cancer cell lines representing five tumor entities, i.e. , ovarian carcinoma (CH1, SK‐OV‐3), cervical carcinoma (HeLa), colon carcinoma (SW480, HCT‐116), osteosarcoma (U‐2 OS), and hepatocellular carcinoma (Hep G2) by means of the MTT (=3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2 H ‐tetrazolium hydrobromide) assay.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.200890197
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2139001-0
SSG:
12
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