In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 9 ( 2021-9-16), p. e1009880-
Abstract:
Staphylococcus aureus is a human commensal organism and opportunist pathogen, causing potentially fatal disease. The presence of non-pathogenic microflora or their components, at the point of infection, dramatically increases S . aureus pathogenicity, a process termed augmentation. Augmentation is associated with macrophage interaction but by a hitherto unknown mechanism. Here, we demonstrate a breadth of cross-kingdom microorganisms can augment S . aureus disease and that pathogenesis of Enterococcus faecalis can also be augmented. Co-administration of augmenting material also forms an efficacious vaccine model for S . aureus . In vitro , augmenting material protects S . aureus directly from reactive oxygen species (ROS), which correlates with in vivo studies where augmentation restores full virulence to the ROS-susceptible, attenuated mutant katA ahpC . At the cellular level, augmentation increases bacterial survival within macrophages via amelioration of ROS, leading to proliferation and escape. We have defined the molecular basis for augmentation that represents an important aspect of the initiation of infection.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009880
DOI:
10.1371/journal.ppat.1009880.g001
DOI:
10.1371/journal.ppat.1009880.g002
DOI:
10.1371/journal.ppat.1009880.g003
DOI:
10.1371/journal.ppat.1009880.g004
DOI:
10.1371/journal.ppat.1009880.g005
DOI:
10.1371/journal.ppat.1009880.g006
DOI:
10.1371/journal.ppat.1009880.t001
DOI:
10.1371/journal.ppat.1009880.s001
DOI:
10.1371/journal.ppat.1009880.s002
DOI:
10.1371/journal.ppat.1009880.s003
DOI:
10.1371/journal.ppat.1009880.s004
DOI:
10.1371/journal.ppat.1009880.s005
DOI:
10.1371/journal.ppat.1009880.s006
DOI:
10.1371/journal.ppat.1009880.s007
DOI:
10.1371/journal.ppat.1009880.s008
DOI:
10.1371/journal.ppat.1009880.s009
DOI:
10.1371/journal.ppat.1009880.r001
DOI:
10.1371/journal.ppat.1009880.r002
DOI:
10.1371/journal.ppat.1009880.r003
DOI:
10.1371/journal.ppat.1009880.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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