In:
Journal of AOAC INTERNATIONAL, Oxford University Press (OUP), Vol. 79, No. 3 ( 1996-05-01), p. 636-639
Abstract:
A liquid chromatographic method was developed for determination of chlorhexidine and its degradation products in unformulated drug substance. A nonlinear gradient from 80% 0.1 M ammonium acetate buffer, pH 5.0, to 20% buffer over 90 min (balance is acetonitrile) is applied to a 3 μm octadecylsilane bonded-phase column. The drug and some of its degradation products are determined at 230 nm. Of 11 previously identified degradation products, 9 are determined with good precision (relative standard deviation of peak area is & lt;2%).
Type of Medium:
Online Resource
ISSN:
1060-3271
,
1944-7922
DOI:
10.1093/jaoac/79.3.636
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
1996
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