In:
Current Topics in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 21, No. 29 ( 2021-12-22), p. 2634-2646
Abstract:
Phytochemicals are the most valuable and comprehensive structures, which may have a
broad range of protective benefits, from reducing inflammation and speeding healing to preventing infection and fighting cancer. Resveratrol (RSV) is a natural phenolic compound from the oligomeric
stilbenoids group, which is usually found in daily human diet, such as grape, peanut, berries and grains. It exhibits anti-inflammatory, neuroprotective, antioxidant, and cancer prevention and treatment
effects. RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS,
BMP7, COX-2, NO, caspases, Wnt, TNFs, NF- & #954;B, EMT, and pentose phosphate pathway. Therefore,
this paper reviews the current researches on the pharmacological effects and pharmacokinetics of resveratrol and its drug delivery system, as well as clinical studies involving CRC.
Type of Medium:
Online Resource
ISSN:
1568-0266
DOI:
10.2174/1568026621666211105093658
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
SSG:
15,3
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