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Morbidity and mortality in a large series of surgical patients with pulmonary metastases of colorectal carcinoma: a prospective multicentre Spanish study (GECMP-CCR-SEPAR)

Rodriguez-Fuster, A. ; Belda-Sanchis, J. ; Aguilo, R. ; [et al.]

Oxford University Press (OUP) ; 2014

In: European Journal of Cardio-Thoracic Surgery Vol. 45, No. 4 ( 2014-04-01), p. 671-676

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In: European Journal of Cardio-Thoracic Surgery, Oxford University Press (OUP), Vol. 45, No. 4 ( 2014-04-01), p. 671-676

Type of Medium: Online Resource

ISSN: 1010-7940 , 1873-734X

URL: Article

DOI: 10.1093/ejcts/ezt459

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2014

detail.hit.zdb_id: 1500330-9

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ACKNOWLEDGEMENT OF REVIEWERS

Adams, NG ; Adekambi, T ; Afeltra, J ; [et al.]

Elsevier BV ; 2011

In: Clinical Microbiology and Infection Vol. 17, No. 1 ( 2011-01), p. 102-103

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In: Clinical Microbiology and Infection, Elsevier BV, Vol. 17, No. 1 ( 2011-01), p. 102-103

Type of Medium: Online Resource

ISSN: 1198-743X

URL: Article

DOI: 10.1111/j.1469-0691.2010.03428.x

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 2020034-1

SSG: 12

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Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Georgiadou, Eleni ; Muralidharan, Charanya ; Martinez, Michelle ; [et al.]

American Diabetes Association ; 2022

In: Diabetes Vol. 71, No. 7 ( 2022-07-01), p. 1472-1489

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In: Diabetes, American Diabetes Association, Vol. 71, No. 7 ( 2022-07-01), p. 1472-1489

Abstract: Mitochondrial glucose metabolism is essential for stimulated insulin release from pancreatic β-cells. Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin signaling has not previously been explored. Here, we generated mice with β-cell–selective, adult-restricted deletion knock-out (dKO) of the mitofusin genes Mfn1 and Mfn2 (βMfn1/2 dKO). βMfn1/2-dKO mice displayed elevated fed and fasted glycemia and a more than fivefold decrease in plasma insulin. Mitochondrial length, glucose-induced polarization, ATP synthesis, and cytosolic and mitochondrial Ca2+ increases were all reduced in dKO islets. In contrast, oral glucose tolerance was more modestly affected in βMfn1/2-dKO mice, and glucagon-like peptide 1 or glucose-dependent insulinotropic peptide receptor agonists largely corrected defective glucose-stimulated insulin secretion through enhanced EPAC-dependent signaling. Correspondingly, cAMP increases in the cytosol, as measured with an Epac-camps–based sensor, were exaggerated in dKO mice. Mitochondrial fusion and fission cycles are thus essential in the β-cell to maintain normal glucose, but not incretin, sensing. These findings broaden our understanding of the roles of mitofusins in β-cells, the potential contributions of altered mitochondrial dynamics to diabetes development, and the impact of incretins on this process.

Type of Medium: Online Resource

ISSN: 0012-1797

URL: Article

DOI: 10.2337/db21-0800

Language: English

Publisher: American Diabetes Association

Publication Date: 2022

detail.hit.zdb_id: 1501252-9

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Nodal Dependent Differential Localisation of Dishevelled-2 Demarcates Regions of Differing Cell Behaviour in the Visceral Endoderm

Trichas, Georgios ; Joyce, Bradley ; Crompton, Lucy A. ; [et al.]

Public Library of Science (PLoS) ; 2011

In: PLoS Biology Vol. 9, No. 2 ( 2011-2-22), p. e1001019-

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In: PLoS Biology, Public Library of Science (PLoS), Vol. 9, No. 2 ( 2011-2-22), p. e1001019-

Type of Medium: Online Resource

ISSN: 1545-7885

URL: Article

DOI: 10.1371/journal.pbio.1001019

DOI: 10.1371/journal.pbio.1001019.g001

DOI: 10.1371/journal.pbio.1001019.g002

DOI: 10.1371/journal.pbio.1001019.g003

DOI: 10.1371/journal.pbio.1001019.g004

DOI: 10.1371/journal.pbio.1001019.g005

DOI: 10.1371/journal.pbio.1001019.g006

DOI: 10.1371/journal.pbio.1001019.g007

DOI: 10.1371/journal.pbio.1001019.s001

DOI: 10.1371/journal.pbio.1001019.s002

DOI: 10.1371/journal.pbio.1001019.s003

DOI: 10.1371/journal.pbio.1001019.s004

DOI: 10.1371/journal.pbio.1001019.s005

DOI: 10.1371/journal.pbio.1001019.s006

DOI: 10.1371/journal.pbio.1001019.s007

DOI: 10.1371/journal.pbio.1001019.s008

DOI: 10.1371/journal.pbio.1001019.s009

DOI: 10.1371/journal.pbio.1001019.s010

DOI: 10.1371/journal.pbio.1001019.s011

DOI: 10.1371/journal.pbio.1001019.s012

DOI: 10.1371/journal.pbio.1001019.s013

DOI: 10.1371/journal.pbio.1001019.s014

DOI: 10.1371/journal.pbio.1001019.s015

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2011

detail.hit.zdb_id: 2126773-X

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BMP signalling inhibits premature neural differentiation in the mouse embryo

Di-Gregorio, Aida ; Sancho, Margarida ; Stuckey, Daniel W. ; [et al.]

The Company of Biologists ; 2007

In: Development Vol. 134, No. 18 ( 2007-09-15), p. 3359-3369

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In: Development, The Company of Biologists, Vol. 134, No. 18 ( 2007-09-15), p. 3359-3369

Abstract: The specification of a subset of epiblast cells to acquire a neural fate constitutes the first step in the generation of the nervous system. Little is known about the signals required for neural induction in the mouse. We have analysed the role of BMP signalling in this process. We demonstrate that prior to gastrulation, Bmp2/4 signalling via Bmpr1a maintains epiblast pluripotency and prevents precocious neural differentiation of this tissue, at least in part by maintaining Nodal signalling. We find that during gastrulation, BMPs of the 60A subgroup cooperate with Bmp2/4 to maintain pluripotency. The inhibition of neural fate by BMPs is independent of FGF signalling, as inhibition of FGF signalling between 5.5 and 7.5 days post-coitum does not block neural differentiation in the mouse embryo. Together, our results demonstrate that inhibition of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not act as neural inducers in the post-implantation mouse embryo.

Type of Medium: Online Resource

ISSN: 1477-9129 , 0950-1991

URL: Article

DOI: 10.1242/dev.005967

Language: English

Publisher: The Company of Biologists

Publication Date: 2007

detail.hit.zdb_id: 2007916-3

SSG: 12

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Chlorella sp.: Potencial biomaterial para tratamiento de agua contaminada con colorantes

Martínez-Tristán, A. ; Liñán Montes, A. ; García Reyes, R.B. ; [et al.]

Universidad Autonoma de Nuevo Leon ; 2011

In: Quimica Hoy Vol. 1, No. 4 ( 2011-09-30), p. 4-

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In: Quimica Hoy, Universidad Autonoma de Nuevo Leon, Vol. 1, No. 4 ( 2011-09-30), p. 4-

Abstract: En este trabajo se evaluó el potencial de la biomasa de Chlorella sp. Para la remoción del colorante tóxico Rojo Congo en muestras de agua contaminada. Se caracterizó la biomasa de Chlorella sp en la que mediante su espectro de FTIR se confirmó la presencia de grupos amino, carboxilo, tiol y fosfatos. Así mismo se mediante potenciometría se encontró que el punto de carga cero (PCC) de la biomasa correspondió a un pH de 6.4 y la concentración de sitios activos fue de 0.65 meq/g de sitios ácidos y 0.6 meq/g de sitios básicos. Las pruebas de biosorción con la biomasa de Chlorella sp. mostraron una alta eficiencia de la remoción, superior al 90% misma que se mantiene en al menos tres ciclos de sorción-desorción. Los resultados obtenidos sugieren que el uso de la biomasa de Chlorella sp. como biosorbente de colorantes en agua contaminada es atractivo tanto desde el punto de vista económico como ambiental

Type of Medium: Online Resource

ISSN: 2007-1183

URL: Article

DOI: 10.29105/qh1.4-115

Language: Unknown

Publisher: Universidad Autonoma de Nuevo Leon

Publication Date: 2011

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DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism

Pernaute, Barbara ; Pérez-Montero, Salvador ; Sánchez Nieto, Juan Miguel ; [et al.]

Elsevier BV ; 2022

In: Developmental Cell Vol. 57, No. 11 ( 2022-06), p. 1316-1330.e7

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In: Developmental Cell, Elsevier BV, Vol. 57, No. 11 ( 2022-06), p. 1316-1330.e7

Type of Medium: Online Resource

ISSN: 1534-5807

URL: Article

DOI: 10.1016/j.devcel.2022.04.020

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2053870-4

SSG: 12

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BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm

Paca, Agnieszka ; Séguin, Cheryle A. ; Clements, Melanie ; [et al.]

Elsevier BV ; 2012

In: Developmental Biology Vol. 361, No. 1 ( 2012-01), p. 90-102

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In: Developmental Biology, Elsevier BV, Vol. 361, No. 1 ( 2012-01), p. 90-102

Type of Medium: Online Resource

ISSN: 0012-1606

URL: Article

DOI: 10.1016/j.ydbio.2011.10.013

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1463203-2

SSG: 12

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Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues

Crompton, Lucy A. ; Du Roure, Camille ; Rodriguez, Tristan A.

Wiley ; 2007

In: Developmental Dynamics Vol. 236, No. 11 ( 2007-11), p. 3137-3143

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In: Developmental Dynamics, Wiley, Vol. 236, No. 11 ( 2007-11), p. 3137-3143

Type of Medium: Online Resource

ISSN: 1058-8388 , 1097-0177

URL: Issue

URL: Article

DOI: 10.1002/dvdy.v236:11

DOI: 10.1002/dvdy.21338

Language: English

Publisher: Wiley

Publication Date: 2007

detail.hit.zdb_id: 1473797-8

SSG: 12

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Activin A directs striatal projection neuron differentiation of human pluripotent stem cells

Arber, Charles ; Precious, Sophie V. ; Cambray, Serafí ; [et al.]

The Company of Biologists ; 2015

In: Development Vol. 142, No. 7 ( 2015-04-01), p. 1375-1386

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In: Development, The Company of Biologists, Vol. 142, No. 7 ( 2015-04-01), p. 1375-1386

Abstract: The efficient generation of striatal neurons from human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) is fundamental for realising their promise in disease modelling, pharmaceutical drug screening and cell therapy for Huntington's disease. GABAergic medium-sized spiny neurons (MSNs) are the principal projection neurons of the striatum and specifically degenerate in the early phase of Huntington's disease. Here we report that activin A induces lateral ganglionic eminence (LGE) characteristics in nascent neural progenitors derived from hESCs and hiPSCs in a sonic hedgehog-independent manner. Correct specification of striatal phenotype was further demonstrated by the induction of the striatal transcription factors CTIP2, GSX2 and FOXP2. Crucially, these human LGE progenitors readily differentiate into postmitotic neurons expressing the striatal projection neuron signature marker DARPP32, both in culture and following transplantation in the adult striatum in a rat model of Huntington's disease. Activin-induced neurons also exhibit appropriate striatal-like electrophysiology in vitro. Together, our findings demonstrate a novel route for efficient differentiation of GABAergic striatal MSNs from human pluripotent stem cells.

Type of Medium: Online Resource

ISSN: 1477-9129 , 0950-1991

URL: Article

DOI: 10.1242/dev.117093

Language: English

Publisher: The Company of Biologists

Publication Date: 2015

detail.hit.zdb_id: 2007916-3

SSG: 12

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