In:
British Journal of Pharmacology, Wiley
Abstract:
Pancreatic cancer is the third leading cause of cancer‐related deaths in the United States, owing to its aggressive nature and suboptimal treatment options, emphasizing the need for novel therapeutic approaches. Emerging studies have exhibited promising results regarding the therapeutic utility of plant‐derived compounds (phytochemicals) in pancreatic cancer. The purpose of this review is to evaluate the potential of phytochemicals in the treatment and prevention of pancreatic cancer. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses was applied to collect articles for this review. Scholarly databases, including PubMed, Scopus, and ScienceDirect, were queried for relevant studies using the following keywords: phytochemicals, phenolics, terpenoids, alkaloids, sulfur‐containing compounds, in vitro , in vivo , clinical studies, pancreatic cancer, tumor, treatment, and prevention. Aggregate results pooled from qualified studies indicate phytochemicals can inhibit pancreatic cancer cell growth or decrease tumor size and volume in animal models. These effects have been attributed to various mechanisms, such as increasing proapoptotic factors, decreasing antiapoptotic factors, or inducing cell death and cell cycle arrest. Notable signaling pathways modulated by phytochemicals include the rat sarcoma/mitogen activated protein kinase, wingless‐related integration site/β‐catenin, and phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin signal transduction pathways. Clinically, phytochemicals have been found to increase survival while being well‐tolerated and safe, though research is scarce. While these promising results have produced great interest in this field, further in‐depth studies are required to characterize the anticancer activities of phytochemicals before they are utilized to prevent or treat pancreatic cancer in clinical practice.
Type of Medium:
Online Resource
ISSN:
0007-1188
,
1476-5381
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2029728-2
SSG:
15,3
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