In:
Cancer Prevention Research, American Association for Cancer Research (AACR), Vol. 4, No. 10_Supplement ( 2011-10-01), p. A89-A89
Abstract:
Background: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation and proliferation and have been found to be associated with risk of cancer of various sites. The results of the prospective studies with respect to pancreatic cancer are rather inconsistent, with most studies showing no clear association of circulating IGF-I or IGFBP-3 levels with pancreatic cancer risk (Douglas et al, 2010; Lin et al, 2004; Stolzenberg-Solomon et al, 2004; Wolpin et al, 2007). Because of the inconsistencies of previous studies, we examined the association between IGF-I, IGFBP-3 and pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Following recruitment of the study participants between 1992 and 2000, 638 pancreatic cancer cases were observed until December 2006; 578 of them were primary exocrine pancreatic tumors. Blood specimens were available for 422 of these cases. Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in these 422 cases and 422 controls matched on age, sex, study center, recruitment date, and time since last meal. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) adjusted for smoking, history of diabetes, and body mass index. Results: Neither circulating levels of IGF-I (OR=1.13, 95% CI 0.63–1.81 for top vs. bottom quartile, p-trend 0.57) nor IGFBP-3 (OR=0.94, 95% CI 0.60–1.47, p-trend 0.65) were statistically significantly associated with the risk of pancreatic cancer. There was also no association of the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level, with pancreatic cancer risk (OR=1.35, 95% CI 0.79–2.31, p-trend 0.31). No associations were observed when using only microscopically confirmed cases (n=307) or when we stratified the analyses by sex, follow-up time, waist circumference, history of type-2 diabetes, or circulating C-peptide concentrations. Conclusion: Based on these results, circulating levels of components of the insulin-like growth factor axis do not appear to be a risk factor for pancreatic cancer, which is consistent with most results of previously published prospective studies. Citation Information: Cancer Prev Res 2011;4(10 Suppl):A89.
Type of Medium:
Online Resource
ISSN:
1940-6207
,
1940-6215
DOI:
10.1158/1940-6207.PREV-11-A89
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2011
detail.hit.zdb_id:
2422346-3
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