In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 10 ( 2021-10-28), p. e0258622-
Abstract:
Chronic Chagas Cardiomyopathy (CCM) is a unique form of cardiomyopathy compared to other etiologies of heart failure. In CCM, risk prediction based on biomarkers has not been well-studied. We assessed the prognostic value of a biomarker panel to predict a composite outcome (CO), including the need for heart transplantation, use of left ventricular assist devices, and mortality. Methods Prospective cohort study of 100 adults with different stages of CCM. Serum concentrations of amino-terminal pro-B type natriuretic peptide (NT-proBNP), galectin-3 (Gal-3), neutrophil gelatinase-associated lipocalin (NGAL), high sensitivity troponin T (hs-cTnT), soluble (sST2), and cystatin-C (Cys-c) were measured. Survival analyses were performed using Cox proportional hazard models. Results During a median follow-up of 52 months, the mortality rate was 20%, while the CO was observed in 25% of the patients. Four biomarkers (NT-proBNP, hs-cTnT, sST2, and Cys-C) were associated with the CO; concentrations of NT-proBNP and hs-cTnT were associated with the highest AUC (85.1 and 85.8, respectively). Combining these two biomarkers above their selected cut-off values significantly increased risk for the CO (HR 3.18; 95%CI 1.31–7.79). No events were reported in the patients in whom the two biomarkers were under the cut-off values, and when both levels were above cut-off values, the CO was observed in 60.71%. Conclusion The combination of NT-proBNP and hs-TnT above their selected cut-off values is associated with a 3-fold increase in the risk of the composite outcome among CCM patients. The use of cardiac biomarkers may improve prognostic evaluation of patients with CCM.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0258622
DOI:
10.1371/journal.pone.0258622.g001
DOI:
10.1371/journal.pone.0258622.g002
DOI:
10.1371/journal.pone.0258622.g003
DOI:
10.1371/journal.pone.0258622.g004
DOI:
10.1371/journal.pone.0258622.t001
DOI:
10.1371/journal.pone.0258622.t002
DOI:
10.1371/journal.pone.0258622.s001
DOI:
10.1371/journal.pone.0258622.s002
DOI:
10.1371/journal.pone.0258622.s003
DOI:
10.1371/journal.pone.0258622.r001
DOI:
10.1371/journal.pone.0258622.r002
DOI:
10.1371/journal.pone.0258622.r003
DOI:
10.1371/journal.pone.0258622.r004
DOI:
10.1371/journal.pone.0258622.r005
DOI:
10.1371/journal.pone.0258622.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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