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Identification of breast cancer biomarkers in transgenic mouse models: A proteomics approach

Rodenburg, Wendy ; Pennings, Jeroen L. A. ; van Oostrom, Conny T. M. ; [et al.]

Wiley ; 2010

In: PROTEOMICS – Clinical Applications Vol. 4, No. 6-7 ( 2010-07), p. 603-612

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In: PROTEOMICS – Clinical Applications, Wiley, Vol. 4, No. 6-7 ( 2010-07), p. 603-612

Abstract: Purpose : Transgenic mouse models for cancer circumvent many challenges that hamper human studies aimed at biomarker discovery. Lower biological variances among mice combined with controllable factors such as food uptake and health status may enable the detection of more subtle protein expression differences. This is envisioned to result in the identification of biomarkers better discriminating cancer cases from controls. Experimental design: The current study used two innovative mouse models for breast‐cancer to identify new serum biomarkers. Multi‐analyte profiling technique was used to analyze 70 proteins in individual serum samples of non‐tumor and mammary tumor‐bearing Tg.NK (MMTV/ c‐neu ) mice. Results : A small set of proteins fully differentiated tumor samples from controls. These comprised osteopontin, interleukin‐18, cystatin C and CD40 antigen. Comparison of protein expression in another breast‐cancer mouse model, the humanized p53.R270H mice, showed common discriminatory expression of osteopontin. However, other biomarkers showed distinct expression in the two different breast‐cancer models, indicating that different mammary tumor sub‐types with respect to molecular and estrogen receptor status reveal divergent serum biomarker sets. Conclusions and clinical relevance: The current study supports the concept that serum proteins can discriminate mammary tumor cases from controls, and yielded interesting biomarkers that need further testing and validation in human studies.

Type of Medium: Online Resource

ISSN: 1862-8346 , 1862-8354

URL: Issue

URL: Article

DOI: 10.1002/prca.v4:6/7

DOI: 10.1002/prca.200900175

Language: English

Publisher: Wiley

Publication Date: 2010

detail.hit.zdb_id: 2317130-3

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2

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Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models

Vitins, Alexa P. ; Kienhuis, Anne S. ; Speksnijder, Ewoud N. ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Archives of Toxicology

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In: Archives of Toxicology, Springer Science and Business Media LLC

Type of Medium: Online Resource

ISSN: 0340-5761 , 1432-0738

URL: Article

DOI: 10.1007/s00204-014-1211-0

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 1458459-1

SSG: 15,3

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3

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Transcriptional profiling reveals progeroid Ercc1 -/Δ mice as a model system for glomerular aging

Schermer, Bernhard ; Bartels, Valerie ; Frommolt, Peter ; [et al.]

Springer Science and Business Media LLC ; 2013

In: BMC Genomics Vol. 14, No. 1 ( 2013-12)

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In: BMC Genomics, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2013-12)

Abstract: Aging-related kidney diseases are a major health concern. Currently, models to study renal aging are lacking. Due to a reduced life-span progeroid models hold the promise to facilitate aging studies and allow examination of tissue-specific changes. Defects in genome maintenance in the Ercc1 -/Δ progeroid mouse model result in premature aging and typical age-related pathologies. Here, we compared the glomerular transcriptome of young and aged Ercc1 -deficient mice to young and aged WT mice in order to establish a novel model for research of aging-related kidney disease. Results In a principal component analysis, age and genotype emerged as first and second principal components. Hierarchical clustering of all 521 genes differentially regulated between young and old WT and young and old Ercc1 -/Δ mice showed cluster formation between young WT and Ercc1 -/Δ as well as old WT and Ercc1 -/Δ samples. An unexpectedly high number of 77 genes were differentially regulated in both WT and Ercc1 -/Δ mice (p 〈 0.0001). GO term enrichment analysis revealed these genes to be involved in immune and inflammatory response, cell death, and chemotaxis. In a network analysis, these genes were part of insulin signaling, chemokine and cytokine signaling and extracellular matrix pathways. Conclusion Beyond insulin signaling, we find chemokine and cytokine signaling as well as modifiers of extracellular matrix composition to be subject to major changes in the aging glomerulus. At the level of the transcriptome, the pattern of gene activities is similar in the progeroid Ercc1 -/Δ mouse model constituting a valuable tool for future studies of aging-associated glomerular pathologies.

Type of Medium: Online Resource

ISSN: 1471-2164

URL: Article

DOI: 10.1186/1471-2164-14-559

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 2041499-7

SSG: 12

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Broad segmental progeroid changes in short-lived Ercc1 −/Δ7 mice

Dollé, Martijn E.T. ; Kuiper, Raoul V. ; Roodbergen, Marianne ; [et al.]

Informa UK Limited ; 2011

In: Pathobiology of Aging & Age-related Diseases Vol. 1, No. 1 ( 2011-01), p. 7219-

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In: Pathobiology of Aging & Age-related Diseases, Informa UK Limited, Vol. 1, No. 1 ( 2011-01), p. 7219-

Type of Medium: Online Resource

ISSN: 2001-0001

URL: Article

DOI: 10.3402/pba.v1i0.7219

Language: English

Publisher: Informa UK Limited

Publication Date: 2011

detail.hit.zdb_id: 2616890-X

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5

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Hydrosurgical and conventional debridement of burns: randomized clinical trial

Legemate, Catherine M. ; Kwa, Kelly A. A. ; Goei, Harold ; [et al.]

Oxford University Press (OUP) ; 2022

In: British Journal of Surgery Vol. 109, No. 4 ( 2022-03-15), p. 332-339

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In: British Journal of Surgery, Oxford University Press (OUP), Vol. 109, No. 4 ( 2022-03-15), p. 332-339

Abstract: Tangential excision of burned tissue followed by skin grafting is the cornerstone of burn surgery. Hydrosurgery has become popular for tangential excision, with the hypothesis that enhanced preservation of vital dermal tissue reduces scarring. The aim of this trial was to compare scar quality after hydrosurgical versus conventional debridement before split-skin grafting. Methods A double-blind randomized within-patient multicentre controlled trial was conducted in patients with burns that required split-skin grafting. One wound area was randomized to hydrosurgical debridement and the other to Weck knife debridement. The primary outcome was scar quality at 12 months, assessed with the observer part of the Patient and Observer Scar Assessment Scale (POSAS). Secondary outcomes included complications, scar quality, colour, pliability, and histological dermal preservation. Results Some 137 patients were randomized. At 12 months, scars of the hydrosurgical debrided wounds had a lower POSAS observer total item score (mean 2.42 (95 per cent c.i. 2.26 to 2.59) versus 2.54 (95 per cent c.i. 2.36 to 2.72; P = 0.023)) and overall opinion score (mean 3.08 (95 per cent c.i. 2.88 to 3.28) versus 3.30 (95 per cent c.i. 3.09–3.51); P = 0.006). Patient-reported scar quality and pliability measurements were significantly better for the hydrosurgically debrided wounds. Complication rates did not differ between both treatments. Histologically, significantly more dermis was preserved with hydrosurgery (P & lt; 0.001). Conclusion One year after surgery scar quality and pliability was better for hydrosurgically debrided burns, probably owing to enhanced histological preservation of dermis. Registration number Trial NL6085 (NTR6232 (http://www.trialregister.nl)).

Type of Medium: Online Resource

ISSN: 0007-1323 , 1365-2168

URL: Article

DOI: 10.1093/bjs/znab470

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2022

detail.hit.zdb_id: 2006309-X

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Identification of proteome markers for drug-induced liver injury in zebrafish embryos

Driessen, Marja ; van der Plas - Duivesteijn, Suzanne ; Kienhuis, Anne S. ; [et al.]

Elsevier BV ; 2022

In: Toxicology Vol. 477 ( 2022-07), p. 153262-

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In: Toxicology, Elsevier BV, Vol. 477 ( 2022-07), p. 153262-

Type of Medium: Online Resource

ISSN: 0300-483X

URL: Article

DOI: 10.1016/j.tox.2022.153262

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 1500781-9

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7

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Accelerated aging pathology in ad libitum fed XpdTTD mice is accompanied by features suggestive of caloric restriction

Wijnhoven, Susan W.P. ; Beems, Rudolf B. ; Roodbergen, Marianne ; [et al.]

Elsevier BV ; 2005

In: DNA Repair Vol. 4, No. 11 ( 2005-11), p. 1314-1324

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In: DNA Repair, Elsevier BV, Vol. 4, No. 11 ( 2005-11), p. 1314-1324

Type of Medium: Online Resource

ISSN: 1568-7864

URL: Article

DOI: 10.1016/j.dnarep.2005.07.002

Language: English

Publisher: Elsevier BV

Publication Date: 2005

detail.hit.zdb_id: 2082770-2

SSG: 12

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Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe

de Vries, Femke A.T. ; Zonneveld, José B.M. ; van Duijn-Goedhart, Annemarie ; [et al.]

Elsevier BV ; 2005

In: DNA Repair Vol. 4, No. 10 ( 2005-9), p. 1121-1128

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In: DNA Repair, Elsevier BV, Vol. 4, No. 10 ( 2005-9), p. 1121-1128

Type of Medium: Online Resource

ISSN: 1568-7864

URL: Article

DOI: 10.1016/j.dnarep.2005.06.002

Language: English

Publisher: Elsevier BV

Publication Date: 2005

detail.hit.zdb_id: 2082770-2

SSG: 12

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9

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Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans

Driessen, Marja ; Kienhuis, Anne S. ; Vitins, Alexa P. ; [et al.]

Elsevier BV ; 2014

In: Toxicology Letters Vol. 230, No. 1 ( 2014-10), p. 48-56

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In: Toxicology Letters, Elsevier BV, Vol. 230, No. 1 ( 2014-10), p. 48-56

Type of Medium: Online Resource

ISSN: 0378-4274

URL: Article

DOI: 10.1016/j.toxlet.2014.06.844

Language: English

Publisher: Elsevier BV

Publication Date: 2014

detail.hit.zdb_id: 1500784-4

SSG: 12

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Mouse Models for Xeroderma Pigmentosum Group A and Group C Show Divergent Cancer Phenotypes

Melis, Joost P.M. ; Wijnhoven, Susan W.P. ; Beems, Rudolf B. ; [et al.]

American Association for Cancer Research (AACR) ; 2008

In: Cancer Research Vol. 68, No. 5 ( 2008-03-01), p. 1347-1353

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In: Cancer Research, American Association for Cancer Research (AACR), Vol. 68, No. 5 ( 2008-03-01), p. 1347-1353

Abstract: The accumulation of DNA damage is a slow but hazardous phenomenon that may lead to cell death, accelerated aging, and cancer. One of the most versatile defense mechanisms against the accumulation of DNA damage is nucleotide excision repair, in which, among others, the Xeroderma pigmentosum group C (XPC) and group A (XPA) proteins are involved. To elucidate differences in the functions of these two proteins, comprehensive survival studies with Xpa−/−, Xpc−/− and wild-type control female mice in a pure C57BL/6J background were done. The median survival of Xpc−/− mice showed a significant decrease, whereas the median survival of Xpa−/− mice did not. Strikingly, Xpa−/− and Xpc−/− mice also showed a phenotypical difference in terms of tumor spectrum. Xpc−/− mice displayed a significant increase in lung tumors and a trend toward increased liver tumors compared with Xpa-deficient or wild-type mice. Xpa−/− mice showed a significant elevation in liver tumors. Additionally, Xpc-deficient mice exhibited a strong increase in mutant frequency in lung compared with Xpa−/− mice, whereas in both models mutant frequency is increased in liver. Our in vitro data displayed an elevated sensitivity to oxygen in Xpc−/− in mouse embryonic fibroblasts (MEF) when compared with Xpa−/− and wild-type fibroblasts. We believe that XPC plays a role in the removal of oxidative DNA damage and that, therefore, Xpc−/− mice display a significant increase in lung tumors and a significant elevation in mutant frequency in lung, and Xpc-deficient MEFs show greater sensitivity to oxygen when compared with Xpa−/− and wild-type mice. [Cancer Res 2008;68(5):1347–53]

Type of Medium: Online Resource

ISSN: 0008-5472 , 1538-7445

URL: Article

DOI: 10.1158/0008-5472.CAN-07-6067

RVK:

XA 36000

RVK:

XA 10000

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2008

detail.hit.zdb_id: 2036785-5

detail.hit.zdb_id: 1432-1

detail.hit.zdb_id: 410466-3

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Kooperativer Bibliotheksverbund

Berlin Brandenburg