In:
American Journal of Rhinology & Allergy, SAGE Publications, Vol. 30, No. 1 ( 2016-01), p. 44-47
Abstract:
Chronic rhinosinusitis (CRS) is a common disease in the United States. There are a significant number of patients with CRS who are refractory to standard medical and surgical therapy. Many of these patients also have comorbid allergic rhinitis (AR) and asthma, although the underlying pathophysiology that connects these three conditions remains unclear. Objective The goal of this article is to review the relationships among CRS, AR and asthma. Methods Scientific literature that addresses the prevalence of AR and asthma in CRS populations, the effect of AR and asthma on CRS disease severity, and whether treatment of AR and asthma can affect CRS outcomes was reviewed. Results The literature supports the relationship between AR and CRS, but there is no direct evidence of causality the between the two conditions. There is a high prevalence of CRS in patients with asthma and the presence of CRS is associated with worse asthma outcomes. There is weak evidence that treatment of CRS may improve asthma outcomes. Targeting type 2 inflammation via biologics is being investigated in the treatment of asthma and CRS. Conclusion AR, asthma, and CRS are closed related and understanding the associations among these comorbid diseases will have significant clinical implication.
Type of Medium:
Online Resource
ISSN:
1945-8924
,
1945-8932
DOI:
10.2500/ajra.2016.30.4252
Language:
English
Publisher:
SAGE Publications
Publication Date:
2016
detail.hit.zdb_id:
2554548-6
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