In:
Lahore Garrison University Journal of Life Sciences, Lahore Garrison University, Vol. 7, No. 02 ( 2023-06-26), p. 173-185
Abstract:
The Human Leukocyte Antigen (HLA) system, a set of highly polymorphic genes, has been found to play an effective role in the disease resistance and disease susceptibility. In this study, prevalence of class-I alleles of HLA was characterized at HLAA,- B and -C loci in the 216 individuals randomly selected population at different regions of Punjab province of Pakistan. The study revealed that at HLA-A locus the allele 11 was most prevalent with 16.7 % frequency. Similarly, at HLA-B locus the allele 51 was found abundant with 15% frequency and at HLA-C locus the allele 7 was prevalent with 24% frequency. Among the two-locus HLA class I haplotypes, B*08/C*07 was found to be the most prevalent followed by B*35/C*04. Surprisingly, HLA-B*29 and HLA-B*36 alleles were found in the Punjabi population which is contrary to the previous reports.
Type of Medium:
Online Resource
ISSN:
2521-0130
,
2519-9404
DOI:
10.54692/lgujls.2023.0702259
Language:
Unknown
Publisher:
Lahore Garrison University
Publication Date:
2023
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