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Tick species from cattle in the Adama Region of Ethiopia and pathogens detected

Tufa, Tafese Beyene ; Wölfel, Silke ; Zubriková, Dana ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Experimental and Applied Acarology Vol. 84, No. 2 ( 2021-06), p. 459-471

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In: Experimental and Applied Acarology, Springer Science and Business Media LLC, Vol. 84, No. 2 ( 2021-06), p. 459-471

Abstract: Ticks will diminish productivity among farm animals and transmit zoonotic diseases. We conducted a study to identify tick species infesting slaughter bulls from Adama City and to screen them for tick-borne pathogens. In 2016, 291 ticks were collected from 37 bulls in Adama, which were ready for slaughter. Ticks were identified morphologically. Total genomic DNA was extracted from ticks and used to test for Rickettsia spp. with real-time PCR. Species identification was done by phylogenetic analysis using sequencing that targeted the 23S-5S intergenic spacer region and ompA genes. Four tick species from two genera, Amblyomma and Rhipicephalus , were identified. Amblyomma cohaerens was the dominant species (n = 241, 82.8%), followed by Amblyomma variegatum (n = 22, 7.5%), Rhipicephalus pulchellus (n = 19, 6.5%), and Rhipicephalus decoloratus (n = 9, 3.0%). Among all ticks, 32 (11%) were positive for Rickettsia spp. and 15 (5.2%) of these were identified as R. africae comprising at least two genetic clades, occurring in A. variegatum (n = 10) and A. cohaerens (n = 5). The remainder of Rickettsia -positive samples could not be amplified due to low DNA yield. Furthermore, another 15 (5.2%) samples carried other pathogenic bacteria: Ehrlichia ruminantium (n = 9; 3.1%) in A. cohaerens , Ehrlichia sp. (n = 3; 1%) in Rh. pulchellus and A. cohaerens , Anaplasma sp. (n = 1; 0.5%) in A. cohaerens , and Neoehrlichia mikurensis (n = 2; 0.7%) in A. cohaerens. All ticks were negative for Bartonella spp., Babesia spp., Theileria spp., and Hepatozoon spp. We reported for the first time E. ruminatium , N. mikurensis , Ehrlichia sp., and Anaplasma sp. in A. cohaerens. Medically and veterinarily important pathogens were mostly detected from A. variegatum and A. cohaerens. These data are relevant for a One-health approach for monitoring and prevention of tick-borne disease transmission.

Type of Medium: Online Resource

ISSN: 0168-8162 , 1572-9702

URL: Article

DOI: 10.1007/s10493-021-00623-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 1497718-7

SSG: 12

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Do Instructional Videos on Sputum Submission Result in Increased Tuberculosis Case Detection? A Randomized Controlled Trial

Mhalu, Grace ; Hella, Jerry ; Doulla, Basra ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS ONE Vol. 10, No. 9 ( 2015-9-29), p. e0138413-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 10, No. 9 ( 2015-9-29), p. e0138413-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0138413

DOI: 10.1371/journal.pone.0138413.g001

DOI: 10.1371/journal.pone.0138413.g002

DOI: 10.1371/journal.pone.0138413.g003

DOI: 10.1371/journal.pone.0138413.g004

DOI: 10.1371/journal.pone.0138413.g005

DOI: 10.1371/journal.pone.0138413.t001

DOI: 10.1371/journal.pone.0138413.t002

DOI: 10.1371/journal.pone.0138413.s001

DOI: 10.1371/journal.pone.0138413.s002

DOI: 10.1371/journal.pone.0138413.s003

DOI: 10.1371/journal.pone.0138413.s004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2267670-3

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Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations

Xu, Zhi Ming ; Rüeger, Sina ; Zwyer, Michaela ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS Computational Biology Vol. 18, No. 1 ( 2022-1-13), p. e1009628-

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In: PLOS Computational Biology, Public Library of Science (PLoS), Vol. 18, No. 1 ( 2022-1-13), p. e1009628-

Abstract: Genome-wide association studies rely on the statistical inference of untyped variants, called imputation, to increase the coverage of genotyping arrays. However, the results are often suboptimal in populations underrepresented in existing reference panels and array designs, since the selected single nucleotide polymorphisms (SNPs) may fail to capture population-specific haplotype structures, hence the full extent of common genetic variation. Here, we propose to sequence the full genomes of a small subset of an underrepresented study cohort to inform the selection of population-specific add-on tag SNPs and to generate an internal population-specific imputation reference panel, such that the remaining array-genotyped cohort could be more accurately imputed. Using a Tanzania-based cohort as a proof-of-concept, we demonstrate the validity of our approach by showing improvements in imputation accuracy after the addition of our designed add-on tags to the base H3Africa array.

Type of Medium: Online Resource

ISSN: 1553-7358

URL: Article

DOI: 10.1371/journal.pcbi.1009628

DOI: 10.1371/journal.pcbi.1009628.g001

DOI: 10.1371/journal.pcbi.1009628.g002

DOI: 10.1371/journal.pcbi.1009628.g003

DOI: 10.1371/journal.pcbi.1009628.g004

DOI: 10.1371/journal.pcbi.1009628.t001

DOI: 10.1371/journal.pcbi.1009628.t002

DOI: 10.1371/journal.pcbi.1009628.s001

DOI: 10.1371/journal.pcbi.1009628.s002

DOI: 10.1371/journal.pcbi.1009628.s003

DOI: 10.1371/journal.pcbi.1009628.s004

DOI: 10.1371/journal.pcbi.1009628.s005

DOI: 10.1371/journal.pcbi.1009628.s006

DOI: 10.1371/journal.pcbi.1009628.s007

DOI: 10.1371/journal.pcbi.1009628.s008

DOI: 10.1371/journal.pcbi.1009628.s009

DOI: 10.1371/journal.pcbi.1009628.s010

DOI: 10.1371/journal.pcbi.1009628.s011

DOI: 10.1371/journal.pcbi.1009628.s012

DOI: 10.1371/journal.pcbi.1009628.s013

DOI: 10.1371/journal.pcbi.1009628.r001

DOI: 10.1371/journal.pcbi.1009628.r002

DOI: 10.1371/journal.pcbi.1009628.r003

DOI: 10.1371/journal.pcbi.1009628.r004

DOI: 10.1371/journal.pcbi.1009628.r005

DOI: 10.1371/journal.pcbi.1009628.r006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2193340-6

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Limited value of whole blood Xpert® MTB/RIF for diagnosing tuberculosis in children

Pohl, Christian ; Rutaihwa, Liliana K. ; Haraka, Frederick ; [et al.]

Elsevier BV ; 2016

In: Journal of Infection Vol. 73, No. 4 ( 2016-10), p. 326-335

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In: Journal of Infection, Elsevier BV, Vol. 73, No. 4 ( 2016-10), p. 326-335

Type of Medium: Online Resource

ISSN: 0163-4453

URL: Article

DOI: 10.1016/j.jinf.2016.04.041

RVK:

XA 54270

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2012883-6

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Evaluation of drug susceptibility profile of Mycobacterium tuberculosis Lineage 1 from Brazil based on whole genome sequencing and phenotypic methods

Guimarães, Arthur Emil dos Santos ; Sharma, Abhinav ; Furlaneto, Ismari Perini ; [et al.]

FapUNIFESP (SciELO) ; 2020

In: Memórias do Instituto Oswaldo Cruz Vol. 115 ( 2020)

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In: Memórias do Instituto Oswaldo Cruz, FapUNIFESP (SciELO), Vol. 115 ( 2020)

Type of Medium: Online Resource

ISSN: 1678-8060 , 0074-0276

URL: Article

DOI: 10.1590/0074-02760200520

Language: English

Publisher: FapUNIFESP (SciELO)

Publication Date: 2020

detail.hit.zdb_id: 2017165-1

SSG: 12

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Table_4.csv

Rutaihwa, Liliana K. ; Menardo, Fabrizio ; Stucki, David ; [et al.]

Frontiers Media SA ; 2019

In: Frontiers in Ecology and Evolution Vol. 7 ( 2019-4-16)

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In: Frontiers in Ecology and Evolution, Frontiers Media SA, Vol. 7 ( 2019-4-16)

Type of Medium: Online Resource

ISSN: 2296-701X

URL: Article

DOI: 10.3389/fevo.2019.00112

DOI: 10.3389/fevo.2019.00112.s001

DOI: 10.3389/fevo.2019.00112.s002

DOI: 10.3389/fevo.2019.00112.s003

DOI: 10.3389/fevo.2019.00112.s004

DOI: 10.3389/fevo.2019.00112.s005

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2019

detail.hit.zdb_id: 2745634-1

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Prevalence and molecular identification of zoonotic Anisakis and Pseudoterranova species in fish destined to human consumption in Chile

Muñoz-Caro, Tamara ; Machuca, Alvaro ; Morales, Pamela ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Parasitology Research Vol. 121, No. 5 ( 2022-05), p. 1295-1304

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In: Parasitology Research, Springer Science and Business Media LLC, Vol. 121, No. 5 ( 2022-05), p. 1295-1304

Abstract: Zoonotic larvae of the family Anisakidae found in several fish species represent a serious risk in public health since they may cause food-borne anisakidosis in humans. Chile has culinary preferences including eating raw fish in many traditional preparations. In the present study, a total of 180 fish specimens representing three different fish species, i.e., Chilean hake ( Merluccius gayi ), snoek ( Thyrsites atun ), and sea bream ( Brama australis ), were caught at central coast of Chile. Parasitological examination was performed on musculature and abdominal cavity for subsequent extraction and quantification of anisakid larvae. Estimation of infection parameters, such as prevalence, was performed indicating 100% (CI: 0.94–1.0) prevalence of anisakid L3 in Chilean hakes and snoeks . Moreover, sea breams reached a prevalence of 35% (CI: 0.23–0.48). Prevalence of anisakid larvae in muscle was also analyzed showing values of 18.6% (CI: 0.097–0.309) in Chilean hakes, 15% (CI: 0.07–0.26) in snoeks, and 1.7% (CI: 0–0.089) in sea breams. Meanwhile, prevalence of anisakid larvae in internal organs showed highest values for peritoneum (100% and 83.3%) for snoeks and Chilean hakes, respectively, for liver (96.7%) and gonads (86.6%) in Chilean hakes, and for intestine (98.3%) in snoeks. Molecular analysis of collected anisakid L3 unveiled presence of two potentially zoonotic nematode species, i.e., Pseudoterranova cattani and Anisakis pegreffii . P. cattani was found in Chilean hakes and snoeks being the first molecular host species report for Chilean snoeks. Besides, A. pegreffii was also identified in these species being the first molecular report on this regard. These findings are relevant for better understanding of epidemiology of anisakiasis in Chilean coasts and for public health issues considering potential risk of human population due to its culinary preferences in eating raw fish.

Type of Medium: Online Resource

ISSN: 0932-0113 , 1432-1955

URL: Article

DOI: 10.1007/s00436-022-07459-x

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 1462976-8

SSG: 12

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Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim

Menardo, Fabrizio ; Rutaihwa, Liliana K. ; Zwyer, Michaela ; [et al.]

F1000 Research Ltd ; 2021

In: F1000Research Vol. 10 ( 2021-2-1), p. 60-

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In: F1000Research, F1000 Research Ltd, Vol. 10 ( 2021-2-1), p. 60-

Type of Medium: Online Resource

ISSN: 2046-1402

URL: Journal

URL: Article

DOI: 10.12688/f1000research

DOI: 10.12688/f1000research.28318.1

Language: English

Publisher: F1000 Research Ltd

Publication Date: 2021

detail.hit.zdb_id: 2699932-8

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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Stucki, David ; Brites, Daniela ; Jeljeli, Leïla ; [et al.]

Springer Science and Business Media LLC ; 2016

In: Nature Genetics Vol. 48, No. 12 ( 2016-12), p. 1535-1543

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 48, No. 12 ( 2016-12), p. 1535-1543

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.3704

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 1494946-5

SSG: 12

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Data_Sheet_1.PDF

Ticlla, Monica R. ; Hella, Jerry ; Hiza, Hellen ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Microbiology Vol. 12 ( 2021-8-20)

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In: Frontiers in Microbiology, Frontiers Media SA, Vol. 12 ( 2021-8-20)

Abstract: Each day, approximately 27,000 people become ill with tuberculosis (TB), and 4,000 die from this disease. Pulmonary TB is the main clinical form of TB, and affects the lungs with a considerably heterogeneous manifestation among patients. Immunomodulation by an interplay of host-, environment-, and pathogen-associated factors partially explains such heterogeneity. Microbial communities residing in the host's airways have immunomodulatory effects, but it is unclear if the inter-individual variability of these microbial communities is associated with the heterogeneity of pulmonary TB. Here, we investigated this possibility by characterizing the microbial composition in the sputum of 334 TB patients from Tanzania, and by assessing its association with three aspects of disease manifestations: sputum mycobacterial load, severe clinical findings, and chest x-ray (CXR) findings. Compositional data analysis of taxonomic profiles based on 16S-rRNA gene amplicon sequencing and on whole metagenome shotgun sequencing, and graph-based inference of microbial associations revealed that the airway microbiome of TB patients was shaped by inverse relationships between Streptococcus and two anaerobes: Selenomonas and Fusobacterium . Specifically, the strength of these microbial associations was negatively correlated with Faith's phylogenetic diversity (PD) and with the accumulation of transient genera. Furthermore, low body mass index (BMI) determined the association between abnormal CXRs and community diversity and composition. These associations were mediated by increased abundance of Selenomonas and Fusobacterium , relative to the abundance of Streptococcus , in underweight patients with lung parenchymal infiltrates and in comparison to those with normal chest x-rays. And last, the detection of herpesviruses and anelloviruses in sputum microbial assemblage was linked to co-infection with HIV. Given the anaerobic metabolism of Selenomonas and Fusobacterium , and the hypoxic environment of lung infiltrates, our results suggest that in underweight TB patients, lung tissue remodeling toward anaerobic conditions favors the growth of Selenomonas and Fusobacterium at the expense of Streptococcus . These new insights into the interplay among particular members of the airway microbiome, BMI, and lung parenchymal lesions in TB patients, add a new dimension to the long-known association between low BMI and pulmonary TB. Our results also drive attention to the airways virome in the context of HIV-TB coinfection.

Type of Medium: Online Resource

ISSN: 1664-302X

URL: Article

DOI: 10.3389/fmicb.2021.633396

DOI: 10.3389/fmicb.2021.633396.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2587354-4

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