KOBV Portal

Hits per page

hits 1 - 10 | 39 hits

Sorting

Online Resource

Epigenetic age is a cell‐intrinsic property in transplanted human hematopoietic cells

Søraas, Arne ; Matsuyama, Mieko ; de Lima, Marcos ; [et al.]

Wiley ; 2019

In: Aging Cell Vol. 18, No. 2 ( 2019-04)

add to watchlist on the watchlist

Details

In: Aging Cell, Wiley, Vol. 18, No. 2 ( 2019-04)

Abstract: The age of tissues and cells can be accurately estimated by DNA methylation analysis. The multitissue DNA methylation (DNAm) age predictor combines the DNAm levels of 353 CpG dinucleotides to arrive at an age estimate referred to as DNAm age. Recent studies based on short‐term observations showed that the DNAm age of reconstituted blood following allogeneic hematopoietic stem cell transplantation (HSCT) reflects the age of the donor. However, it is not known whether the DNAm age of donor blood remains independent of the recipient's age over the long term. Importantly, long‐term studies including child recipients have the potential to clearly reveal whether DNAm age is cell‐intrinsic or whether it is modulated by extracellular cues in vivo. Here, we address this question by analyzing blood methylation data from HSCT donor and recipient pairs who greatly differed in chronological age (age differences between 1 and 49 years). We found that the DNAm age of the reconstituted blood was not influenced by the recipient's age, even 17 years after HSCT, in individuals without relapse of their hematologic disorder. However, the DNAm age of recipients with relapse of leukemia was unstable. These data are consistent with our previous findings concerning the abnormal DNAm age of cancer cells, and it can potentially be exploited to monitor the health of HSCT recipients. Our data demonstrate that transplanted human hematopoietic stem cells have an intrinsic DNAm age that is unaffected by the environment in a recipient of a different age.

Type of Medium: Online Resource

ISSN: 1474-9718 , 1474-9726

URL: Issue

URL: Article

DOI: 10.1111/acel.2019.18.issue-2

DOI: 10.1111/acel.12897

Language: English

Publisher: Wiley

Publication Date: 2019

detail.hit.zdb_id: 2099130-7

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

ISARIC Clinical Characterization Group ; Abbas, Ali ; Abdukahil, Sheryl Ann ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Scientific Data Vol. 9, No. 1 ( 2022-07-30)

add to watchlist on the watchlist

Details

In: Scientific Data, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2022-07-30)

Abstract: The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.

Type of Medium: Online Resource

ISSN: 2052-4463

URL: Article

DOI: 10.1038/s41597-022-01534-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2775191-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial

Brunvoll, Sonja H ; Nygaard, Anders B ; Ellingjord-Dale, Merete ; [et al.]

BMJ ; 2022

In: BMJ

add to watchlist on the watchlist

Details

In: BMJ, BMJ

Abstract: To determine if daily supplementation with cod liver oil, a low dose vitamin D supplement, in winter, prevents SARS-CoV-2 infection, serious covid-19, or other acute respiratory infections in adults in Norway. Design Quadruple blinded, randomised placebo controlled trial. Setting Norway, 10 November 2020 to 2 June 2021. Participants 34 601 adults (aged 18-75 years), not taking daily vitamin D supplements. Intervention 5 mL/day of cod liver oil (10 µg of vitamin D, n=17 278) or placebo (n=17 323) for up to six months. Main outcome measures Four co-primary endpoints were predefined: the first was a positive SARS-CoV-2 test result determined by reverse transcriptase-quantitative polymerase chain reaction and the second was serious covid-19, defined as self-reported dyspnoea, admission to hospital, or death. Other acute respiratory infections were indicated by the third and fourth co-primary endpoints: a negative SARS-CoV-2 test result and self-reported symptoms. Side effects related to the supplementation were self-reported. The fallback method was used to handle multiple comparisons. Results Supplementation with cod liver oil was not associated with a reduced risk of any of the co-primary endpoints. Participants took the supplement (cod liver oil or placebo) for a median of 164 days, and 227 (1.31%) participants in the cod liver oil group and 228 (1.32%) participants in the placebo group had a positive SARS-CoV-2 test result (relative risk 1.00, multiple comparison adjusted confidence interval 0.82 to 1.22). Serious covid-19 was identified in 121 (0.70%) participants in the cod liver oil group and in 101 (0.58%) participants in the placebo group (1.20, 0.87 to 1.65). 8546 (49.46%) and 8565 (49.44%) participants in the cod liver oil and placebo groups, respectively, had ≥1 negative SARS-CoV-2 test results (1.00, 0.97 to 1.04). 3964 (22.94%) and 3834 (22.13%) participants in the cod liver oil and placebo groups, respectively, reported ≥1 acute respiratory infections (1.04, 0.97 to 1.11). Only low grade side effects were reported in the cod liver oil and placebo groups. Conclusion Supplementation with cod liver oil in the winter did not reduce the incidence of SARS-CoV-2 infection, serious covid-19, or other acute respiratory infections compared with placebo. Trial registration ClinicalTrials.gov NCT04609423 .

Type of Medium: Online Resource

ISSN: 1756-1833

URL: Article

DOI: 10.1136/bmj-2022-071245

Language: English

Publisher: BMJ

Publication Date: 2022

detail.hit.zdb_id: 1479799-9

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Persisting symptoms three to eight months after non-hospitalized COVID-19, a prospective cohort study

Søraas, Arne ; Kalleberg, Karl Trygve ; Dahl, John Arne ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 8 ( 2021-8-26), p. e0256142-

add to watchlist on the watchlist

Details

In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 8 ( 2021-8-26), p. e0256142-

Abstract: Long-COVID-19 is a proposed syndrome negatively affecting the health of COVID-19 patients. We present data on self-rated health three to eight months after laboratory confirmed COVID-19 disease compared to a control group of SARS-CoV-2 negative patients. We followed a cohort of 8786 non-hospitalized patients who were invited after SARS-CoV-2 testing between February 1 and April 15, 2020 (794 positive, 7229 negative). Participants answered online surveys at baseline and follow-up including questions on demographics, symptoms, risk factors for SARS-CoV-2, and self-rated health compared to one year ago. Determinants for a worsening of self-rated health as compared to one year ago among the SARS-CoV-2 positive group were analyzed using multivariate logistic regression and also compared to the population norm. The follow-up questionnaire was completed by 85% of the SARS-CoV-2 positive and 75% of the SARS-CoV-2 negative participants on average 132 days after the SARS-CoV-2 test. At follow-up, 36% of the SARS-CoV-2 positive participants rated their health “somewhat” or “much” worse than one year ago. In contrast, 18% of the SARS-CoV-2 negative participants reported a similar deterioration of health while the population norm is 12%. Sore throat and cough were more frequently reported by the control group at follow-up. Neither gender nor follow-up time was associated with the multivariate odds of worsening of self-reported health compared to one year ago. Age had an inverted-U formed association with a worsening of health while being fit and being a health professional were associated with lower multivariate odds. A significant proportion of non-hospitalized COVID-19 patients, regardless of age, have not returned to their usual health three to eight months after infection.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0256142

DOI: 10.1371/journal.pone.0256142.g001

DOI: 10.1371/journal.pone.0256142.g002

DOI: 10.1371/journal.pone.0256142.g003

DOI: 10.1371/journal.pone.0256142.t001

DOI: 10.1371/journal.pone.0256142.t002

DOI: 10.1371/journal.pone.0256142.t003

DOI: 10.1371/journal.pone.0256142.t004

DOI: 10.1371/journal.pone.0256142.s001

DOI: 10.1371/journal.pone.0256142.s002

DOI: 10.1371/journal.pone.0256142.s003

DOI: 10.1371/journal.pone.0256142.s004

DOI: 10.1371/journal.pone.0256142.s005

DOI: 10.1371/journal.pone.0256142.r001

DOI: 10.1371/journal.pone.0256142.r002

DOI: 10.1371/journal.pone.0256142.r003

DOI: 10.1371/journal.pone.0256142.r004

DOI: 10.1371/journal.pone.0256142.r005

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Dispersion of SARS‐CoV‐2 in air surrounding COVID‐19‐infected individuals with mild symptoms

Gohli, Jostein ; Anderson, Ane Marie ; Brantsæter, Arne Broch ; [et al.]

Hindawi Limited ; 2022

In: Indoor Air Vol. 32, No. 2 ( 2022-02)

add to watchlist on the watchlist

Details

In: Indoor Air, Hindawi Limited, Vol. 32, No. 2 ( 2022-02)

Type of Medium: Online Resource

ISSN: 0905-6947 , 1600-0668

URL: Issue

URL: Article

DOI: 10.1111/ina.v32.2

DOI: 10.1111/ina.13001

Language: English

Publisher: Hindawi Limited

Publication Date: 2022

detail.hit.zdb_id: 2028169-9

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

The use of public transport and contraction of SARS-CoV-2 in a large prospective cohort in Norway

Ellingjord-Dale, Merete ; Kalleberg, Karl Trygve ; Istre, Mette S. ; [et al.]

Springer Science and Business Media LLC ; 2022

In: BMC Infectious Diseases Vol. 22, No. 1 ( 2022-12)

add to watchlist on the watchlist

Details

In: BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)

Abstract: For many people public transport is the only mode of travel, and it can be challenging to keep the necessary distances in such a restricted space. The exact role of public transportation and risk of SARS-CoV-2 transmission is not known. Methods Participants (n = 121,374) were untested adult Norwegian residents recruited through social media who in the spring of 2020 completed a baseline questionnaire on demographics and the use of public transport. Incident cases (n = 1069) had a positive SARS-CoV-2 polymerase chain reaction test registered at the Norwegian Messaging System for Infectious Diseases by January 27, 2021. We investigated the association between the use of public transport and SARS-CoV-2 using logistic regression. Odds ratios (ORs) with 95% confidence intervals (CIs) adjusted for age, calendar time, gender, municipality, smoking, income level, fitness and underlying medical conditions were estimated. Frequency of the use of public transport was reported for 2 week-periods. Results Before lockdown, those who tested positive on SARS-CoV-2 were more likely to have used public transport 1–3 times (OR = 1.28, CI 1.09–1.51), 4–10 times (OR = 1.49, CI 1.26–1.77) and ≥ 11 times (OR = 1.50, CI 1.27–1.78, p for trend 〈 0.0001) than those who had not tested positive. Conclusion The use of public transport was positively associated with contracting SARS-CoV-2 both before and after lockdown.

Type of Medium: Online Resource

ISSN: 1471-2334

URL: Article

DOI: 10.1186/s12879-022-07233-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2041550-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Post-acute symptoms 3-15 months after COVID-19 among unvaccinated and vaccinated individuals with a breakthrough infection

Brunvoll, Sonja H. ; Nygaard, Anders B. ; Fagerland, Morten W. ; [et al.]

Elsevier BV ; 2023

In: International Journal of Infectious Diseases Vol. 126 ( 2023-01), p. 10-13

add to watchlist on the watchlist

Details

In: International Journal of Infectious Diseases, Elsevier BV, Vol. 126 ( 2023-01), p. 10-13

Type of Medium: Online Resource

ISSN: 1201-9712

URL: Article

DOI: 10.1016/j.ijid.2022.11.009

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2070533-5

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after COVID-19 hospitalization: an international multicenter prospective observational study

Cho, Sung-Min ; Premraj, Lavienraj ; Battaglini, Denise ; [et al.]

Oxford University Press (OUP) ; 2024

In: Brain Communications

add to watchlist on the watchlist

Details

In: Brain Communications, Oxford University Press (OUP)

Abstract: Although it is known that COVID-19 can present with a range of neurological manifestations and in-hospital complications, sparse data exist if these initial neurological symptoms of COVID-19 are closely associated with post-acute neurological sequelae of SARS-CoV-2 (PANSC) and if female versus male sex impacts the symptom resolution. In this international, multicentre, prospective observational study across 407 sites from 15 countries (January/30th/2020-April/30th/2022), we report the prevalence and risk factors of PANSC among hospitalized adults and investigate the differences between males and females on neurological symptom resolution over time. PANSC included altered consciousness/confusion, fatigue/malaise, anosmia, dysgeusia, and muscle aches/joint pain, which were collected at the index hospitalization and during the follow-up assessments. The analysis considered time to resolution of individual and all neurological symptoms. Resulting times were modeled by Weibull regression, assuming mixed-case interval censoring, with sex and age included as covariates. Model results were summarized as cumulative probability functions and age- and sex-adjusted median times to resolution. We included 6,862 hospitalized adults with COVID-19, who had follow-up assessments. The median age of participants was 57 years (39.2% females). Males and females had similar baseline characteristics except that more males (vs. females) were admitted to Intensive Care Unit (30.5% vs. 20.3%) and received mechanical ventilation (17.2% vs. 11.8%). Approximately 70% of patients had multiple neurological symptoms at the first follow-up (median=102 days). Fatigue (49.9%) and myalgia/arthralgia (45.2%) were the most prevalent symptoms of PANSC at the initial follow-up. Reported prevalence in females was generally higher (vs. males) for all symptoms. At 12 months, anosmia and dysgeusia were resolved in most patients, though fatigue, altered consciousness, and myalgia remained unresolved in & gt;10% of the cohort. Females had a longer time to resolution (5.2 vs. 3.4 months) of neurological symptoms at follow-up for those with more than one neurological symptom. In multivariable analysis, males were associated with a shorter time to resolution of symptoms (Hazard Ratio=1.53; 95% Confidence Interval =1.39–1.69). Intensive Care Unit admission was associated with a longer time to the resolution of symptoms (Hazard Ratio =0.68; 95% Confidence Interval=0.60–0.77). Post-discharge stroke was uncommon (0.3% in females; 0.5% in males). Despite the methodological challenges of survey data, this international multicentre prospective cohort study demonstrates that PANSC following index hospitalization is high. Symptom prevalence was higher and took longer to resolve in females than in males. This supports that whilst males were sicker during acute illness, females were disproportionately affected by PANSC.

Type of Medium: Online Resource

ISSN: 2632-1297

URL: Article

DOI: 10.1093/braincomms/fcae036

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2024

detail.hit.zdb_id: 3020013-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

EWAS of post-COVID-19 patients shows methylation differences in the immune-response associated gene, IFI44L, three months after COVID-19 infection

Lee, Yunsung ; Riskedal, Espen ; Kalleberg, Karl Trygve ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Scientific Reports Vol. 12, No. 1 ( 2022-07-07)

add to watchlist on the watchlist

Details

In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-07-07)

Abstract: Although substantial progress has been made in managing COVID-19, it is still difficult to predict a patient’s prognosis. We explored the epigenetic signatures of COVID-19 in peripheral blood using data from an ongoing prospective observational study of COVID-19 called the Norwegian Corona Cohort Study. A series of EWASs were performed to compare the DNA methylation profiles between COVID-19 cases and controls three months post-infection. We also investigated differences associated with severity and long-COVID. Three CpGs—cg22399236, cg03607951, and cg09829636—were significantly hypomethylated (FDR 〈 0.05) in COVID-19 positive individuals. cg03607951 is located in IFI44L which is involved in innate response to viral infection and several systemic autoimmune diseases. cg09829636 is located in ANKRD9 , a gene implicated in a wide variety of cellular processes, including the degradation of IMPDH2. The link between ANKRD9 and IMPDH2 is striking given that IMPDHs are considered therapeutic targets for COVID-19. Furthermore, gene ontology analyses revealed pathways involved in response to viruses. The lack of significant differences associated with severity and long-COVID may be real or reflect limitations in sample size. Our findings support the involvement of interferon responsive genes in the pathophysiology of COVID-19 and indicate a possible link to systemic autoimmune diseases.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-022-15467-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2615211-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Epigenetic aging of human blood cells is influenced by the age of the host body

Holland, Petter ; Istre, Mette ; Ali, Maryan M. ; [et al.]

Wiley ; 2024

In: Aging Cell

add to watchlist on the watchlist

Details

In: Aging Cell, Wiley

Abstract: Allogenic hematopoietic stem cell transplantation is a therapeutic procedure performed over a wide range of donor and recipient age combinations, representing natural experiments of how the age of the recipient affects aging in transplanted donor cells in vivo. We measured DNA methylation and epigenetic aging in donors and recipients and found that biological epigenetic clocks are accelerated in cells transplanted into an older body and decelerated in a younger body. This is the first evidence that the age of the circulating environment influences human epigenetic aging in vivo.

Type of Medium: Online Resource

ISSN: 1474-9718 , 1474-9726

URL: Article

DOI: 10.1111/acel.14112

Language: English

Publisher: Wiley

Publication Date: 2024

detail.hit.zdb_id: 2099130-7

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 39 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg