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  • 1
    Online Resource
    Online Resource
    Wiley ; 2019
    In:  Vox Sanguinis Vol. 114, No. 2 ( 2019-02), p. 154-161
    In: Vox Sanguinis, Wiley, Vol. 114, No. 2 ( 2019-02), p. 154-161
    Abstract: Previous studies observed a transient increase in well‐being in about one‐third of regular donors after blood donation. In addition, personal contact with donors after donation seems to increase return rates. We were interested whether changes in well‐being and/or personal contact after the first donation impact return rates of first‐time donors ( FTD s). Materials and methods First‐time donors were randomized to a questionnaire group ( QG ), in which questionnaires assessing the well‐being had to be filled in, or a control group ( CG ), which was not contacted with a questionnaire. The QG had to complete the same questionnaire three times at the day of the first donation and then four times over an 8‐week period with reminding calls by the study coordinator. Return rates of participants were followed for 12 months. Results A total of 102 FTD s participated in the QG and 115 in the CG . Changes in well‐being after the first donation had minimal impact on the return rates. In contrast, contacting FTD s after their first donation had a significant impact on the return rate of male donors (89·2% in the QG vs. 58·3% in the CG ; P  = 0·001). Females showed no significant difference in return rates between both groups ( P  = 0·32). Conclusion The well‐being of FTD s had no influence on their return rate. The intervention of regular contacts during a research project follow‐up resulted in an increased return rate of male but not of female FTD s. The pronounced difference of the impact of this intervention between male and female donors requires further studies.
    Type of Medium: Online Resource
    ISSN: 0042-9007 , 1423-0410
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1483587-3
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  • 2
    In: Pharmaceuticals, MDPI AG, Vol. 15, No. 11 ( 2022-11-19), p. 1437-
    Abstract: Background: Phenprocoumon has been used as an oral anticoagulant in patients with thromboembolic disease for more than 40 years. So far its pharmacokinetics have not been analyzed in emergency situations. Methods: Phenprocoumon-treated patients with major bleeding or urgent surgery were included in a prospective, observational registry. Phenprocoumon drug concentrations were analyzed in samples, collected as part of routine care using ultraperformance liquid chromatography tandem mass spectrometry. Moreover, anticoagulant intensity and drug half-life (t1/2) were calculated. Results: 115 patients were included. Phenprocoumon levels declined over time with a half-life of 5.27 and 5.29 days in patients with major bleedings (n = 82) and with urgent surgery (n = 33). Baseline phenprocoumon levels were 2.2 times higher in the bleeding group compared to the surgery group (1.92 vs. 0.87 ng/mL, p 〈 0.0001). International normalized ratio (INR) values decreased rapidly during the first 24 h. In 27.6% of patients a rebound of INR (recurrent increase 〉 1.5) was observed which was associated with significantly increased bleeding rates (22% vs. 4.2% in patients with or without INR rebound, p = 0.012). Conclusions: In emergency situations, the long half-life of phenprocoumon may cause INR rebound and associated recurrent bleedings. Optimal management may need to include repeated vitamin K supplementation over days.
    Type of Medium: Online Resource
    ISSN: 1424-8247
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2193542-7
    SSG: 15,3
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  • 3
    In: Transfusion Medicine and Hemotherapy, S. Karger AG, Vol. 48, No. 4 ( 2021), p. 220-227
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 To maintain a sufficient donor pool, deferred first-time donors (FTD) should be motivated to return for blood donation. This pilot study investigates how deferral affects momentary mood, satisfaction with the donation process, and subsequent return behavior to examine their potential for motivating (deferred) FTD. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 All of the subjects ( 〈 i 〉 n 〈 /i 〉 = 96) completed a first questionnaire (A1) before pre-donation assessment. Deferred FTD ( 〈 i 〉 n 〈 /i 〉 = 22) were asked to complete a second questionnaire (A2) immediately after deferral, while non-deferred FTD ( 〈 i 〉 n 〈 /i 〉 = 74) filled in the second questionnaire (A3) after blood donation. The impact of deferral, momentary mood, and satisfaction with the donation process on return behavior within 12 months was tested by calculating two path analyses, controlling for sex and age. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Mood ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) and satisfaction with social aspects of the donation process ( 〈 i 〉 p 〈 /i 〉 = 0.01) were decreased after deferral. Deferred FTD were less likely than non-deferred FTD to return to the blood donation center within 12 months (60.8 vs. 36.4%; 〈 i 〉 p 〈 /i 〉 = 0.043). However, path analyses revealed that deferral effects on mood and satisfaction were not connected to return behavior. Instead, age had a significant influence on return behavior ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05) such that, overall, non-returning FTD were older than returning FTD, regardless of their deferral status. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our findings suggest that mood and satisfaction with the donation process are directly affected by deferral but not clearly responsible for low return rates. It seems promising to embed these variables in established health behavior models in further studies to increase the return rates of deferred FTD.
    Type of Medium: Online Resource
    ISSN: 1660-3796 , 1660-3818
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 2100533-3
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  • 4
    Online Resource
    Online Resource
    S. Karger AG ; 2015
    In:  Transfusion Medicine and Hemotherapy Vol. 42, No. 5 ( 2015), p. 340-343
    In: Transfusion Medicine and Hemotherapy, S. Karger AG, Vol. 42, No. 5 ( 2015), p. 340-343
    Abstract: 〈 b 〉 Background: 〈 /b 〉 The phenomena of co-incidence of transfusion-induced allo- and autoantibodies, blockage and/or loss of red blood cell (RBC) antigens are conspicuous and may result in confusion and misdiagnosis. 〈 b 〉 Case Report: 〈 /b 〉 A 67-year-old female was transferred to the intensive care unit due to hemolysis which developed 2 days following transfusion of three Rh(D)-negative RBC units in the presence of strongly reactive autoantibodies. Standard serological testing and genotyping were performed. Upon arrival, the patient was typed as Ccddee. Her hemolysis was decompensated, and an immediate blood transfusion was required. In addition, direct and indirect antiglobulin tests (DAT and IAT) as well as the eluate were strongly positive. Emergency transfusion of Rh(D)-negative RBCs resulted in increased hemolysis and renal failure. An exhaustive testing revealed anti-D, anti-c, CCddee phenotype and CCD.ee genotype. Three units of cryopreserved CCddee RBCs were transfused, and the patient's condition immediately improved. The discrepancy between Rh-D phenotyping and genotyping was likely caused by masking of the D-epitopes by the autoantibodies. In fact, further enquiry revealed that the patient had been phenotyped as Rh(D)-positive 6 months ago and had been transfused at that time following hip surgery. 〈 b 〉 Conclusion: 〈 /b 〉 The phenomena of transfusion-induced autoantibodies, masked alloantibodies, antigen blockage and/or loss are rare but important features which should be considered in patients presenting with autoimmune hemolytic anemia and/or hemolytic transfusion reactions.
    Type of Medium: Online Resource
    ISSN: 1660-3796 , 1660-3818
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 2100533-3
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  • 5
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2018
    In:  Transfusionsmedizin - Immunhämatologie, Hämotherapie, Immungenetik, Zelltherapie Vol. 8, No. 01 ( 2018-02), p. 24-32
    In: Transfusionsmedizin - Immunhämatologie, Hämotherapie, Immungenetik, Zelltherapie, Georg Thieme Verlag KG, Vol. 8, No. 01 ( 2018-02), p. 24-32
    Abstract: Das derzeitige Verhältnis von Vollblutspendern und -empfängern 1 wird in Zukunft weiter aus dem Gleichgewicht geraten: Der demografische Wandel und die Zunahme von Spenderausschlusskriterien führen zu einer Reduktion potenzieller Vollblutspender, während der Bedarf an Blutprodukten weiterhin steigt. Aus diesem Grund wird die Rekrutierung von Neuspendern allein nicht ausreichend sein, um einen stabilen Spenderpool zu erhalten. Um die Versorgung mit Blutprodukten zukünftig trotzdem gewährleisten zu können, rücken alternative Interventionsoptionen zunehmend in den Vordergrund. Der vorliegende Artikel zeigt psychologische Optionen auf, die auf die Begrenzung des drohenden Blutkonservenmangels abzielen, und richtet dabei den Fokus auf die wichtigste Ressource 2 – den Blutspender. Dafür sollen ergänzende Reaktivierungsmaßnahmen, die der Initiierung eines erneuten Blutspendeversuchs dienen, erläutert und diskutiert werden. Anschließend wird das Konstrukt der Spenderloyalität als eine aussichtsreiche Möglichkeit der langfristigen Spenderbindung vorgestellt.
    Type of Medium: Online Resource
    ISSN: 2191-8805 , 2191-8813
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2018
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2018
    In:  Transfusion Vol. 58, No. 10 ( 2018-10), p. 2257-2259
    In: Transfusion, Wiley, Vol. 58, No. 10 ( 2018-10), p. 2257-2259
    Abstract: Social media platforms have become an important lifestyle aspect. Therefore, we implemented communication via social media platforms to recruit new donors and to motivate repeat donors. Here, we report a survey among donors of our blood donation facility to evaluate the impact of different strategies for donor motivation from the donors’ perspective. STUDY DESIGN AND METHODS During 8 consecutive weeks, all whole blood donors were asked to participate. The survey consisted of a questionnaire including the demographic items sex, age, number of prior donations, and 14 potential motivators for blood donation. Social media included the items “ Facebook ” and “ Jodel” (German local mobile application). RESULTS Of 3320 consecutive donors, 2920 (88%) participated in the survey. Social media motivated 7.4% of our donors, among them mainly young and female donors. For first‐time donors (FTDs; n = 157) the three strongest motivational factors were friends and/or relatives (73%), social media (15%), and “I do not need additional motivation” (11%). Repeat donors (n = 2693) most often stated that they do not need additional motivation (72%) and only 7% were motivated by social media. CONCLUSION Social media have become the second most important motivator to recruit FTDs beside relatives and friends who are by far the main motivators for FTDs. For repeat donors, social media play a less important role. Social media are becoming increasingly important for transfusion services.
    Type of Medium: Online Resource
    ISSN: 0041-1132 , 1537-2995
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2018415-3
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  • 7
    In: Deutsches Ärzteblatt international, Deutscher Arzte-Verlag GmbH, ( 2020-05-01)
    Type of Medium: Online Resource
    ISSN: 1866-0452
    Language: German
    Publisher: Deutscher Arzte-Verlag GmbH
    Publication Date: 2020
    detail.hit.zdb_id: 2406159-1
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  • 8
    In: Transfusion Medicine and Hemotherapy, S. Karger AG, Vol. 44, No. 4 ( 2017), p. 232-239
    Abstract: 〈 b 〉 Background: 〈 /b 〉 We assessed the effect of the uniform donor questionnaire (UDQ) on deferral rates in first-time and repeat donors. We focused on the introduced question about unprotected sexual contact with a new partner. Another goal was a stratified comparison of the deferral rates of the donor questionnaire (DQ) and UDQ. 〈 b 〉 Methods: 〈 /b 〉 Data on donors and deferrals using the DQ and UDQ were collected at four blood establishments. The comparison included a 2-year period by questionnaire version. For the comparison of the questionnaires, an adjusted multinomial logistic regression was performed. 〈 b 〉 Results: 〈 /b 〉 The analysis included 260,848 donations. First-time (FTD) and repeat donations (RD) showed higher deferral rates with the UDQ (FTD +5.4%, RD +1.4%). Deferral due to a new partner was 3.0% in first-time and 0.4% in repeat donors. The majority of these occurred in the youngest age groups. The most frequent deferral criterion was ‘disease' (5.1%). 〈 b 〉 Conclusion: 〈 /b 〉 The regression revealed stronger predictors for deferral than the questionnaire version. Especially younger age carried a higher and independent risk for deferral. The additional deferrals of mainly young first-time donors due to a new sexual partner may identify those donors with potential heterosexual risk behavior who would otherwise not be identified.
    Type of Medium: Online Resource
    ISSN: 1660-3796 , 1660-3818
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 2100533-3
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  • 9
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 122, No. 04 ( 2022-04), p. 552-559
    Abstract: Background Direct oral anticoagulants (DOACs) are increasingly used worldwide. Little is known so far about their pharmacokinetics in emergency situations. Methods A prospective, observational registry was performed to determine the clinical course in consecutive patients with major bleeding or urgent surgery treated with DOACs. In samples collected as part of routine care DOAC drug concentrations were measured using ultraperformance liquid chromatography-tandem mass spectrometry. Anticoagulant intensity at first presentation and drug half-life (t 1/2), tested in repeat samples, were evaluated. Results A total of 140 patients were prospectively included. Pharmacokinetic data were available in 94% (132/140) of patients. Note that 67% (89/132) experienced life-threatening bleeding and 33% (43/132) needed an urgent surgery. For pharmacokinetic analysis a total of 605 blood samples was available. Median concentration on admission was 205 ng/mL for rivaroxaban and 108 ng/mL for apixaban. All treatment groups showed a high variation of drug concentrations at baseline. In rivaroxaban-treated patients t ½ was 17.3 hours (95% confidence interval [CI] : 15.4–19.7) without significant difference in both groups (major bleeding: t ½ 16.7 hours, 95% CI: 14.7–19.3; urgent surgery: t ½ 19.7 hours, 95% CI: 15.2–27.9; p = 0.292). In apixaban-treated patients t ½ was 25.0 hours (95% CI: 22.9–27.6) with a longer t ½ after urgent surgery (t 1/2: 30.8 hours; 95% CI: 26.9–36.4) compared with severe bleeding (t 1/2: 20.8 hours; 95% CI: 18.8–23.2; p  〈  0.001). Conclusion Emergency patients under DOAC treatment show a high variation of anticoagulant concentrations at baseline. Compared with rivaroxaban, apixaban showed a lower median concentration on admission and a longer t ½.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
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  • 10
    Online Resource
    Online Resource
    S. Karger AG ; 2022
    In:  Transfusion Medicine and Hemotherapy Vol. 49, No. 2 ( 2022), p. 67-75
    In: Transfusion Medicine and Hemotherapy, S. Karger AG, Vol. 49, No. 2 ( 2022), p. 67-75
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Previous studies suggest that blood donation impacts blood donors’ psychological state, with either positive or negative effects, such as feeling more energetic or more exhausted. It has not yet been described how long these effects last. 〈 b 〉 〈 i 〉 Materials and Methods: 〈 /i 〉 〈 /b 〉 This prospective cohort study consisted of a qualitative and a quantitative part: (1) Psychological characteristics which changed after blood donation were identified by structured interviews of regular whole blood donors ( 〈 i 〉 n 〈 /i 〉 = 42). Based on this, a questionnaire addressing 7 psychological dimensions was established. (2) The psychological state of 100 blood donors was assessed after blood donation by applying the questionnaire 15–30 min before and during donation, as well as 15–30 min, 6 h, 24 h, 72 h, 1 week, and 8 weeks after donation. The resulting changes were summarized to a score. Furthermore, potential correlations of the score with pre-donation blood pressure, hemoglobin, or body mass index were calculated. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Seven items were identified which changed in at least 25% of blood donors (mood, concentration, satisfaction, resilience, spirit of initiative, physical well-being, energy level). In the 100 blood donors, the well-being score increased (positive effects, 〈 i 〉 n 〈 /i 〉 = 23), showed minor changes ( 〈 i 〉 n 〈 /i 〉 = 53), or decreased (negative effects, 〈 i 〉 n 〈 /i 〉 = 24). The positive effects lasted for about 1 week and the negative effects for 3 days. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 While the frequency of psychological effects following blood donation identified by our study was comparable to others, the changes of the psychological state in our donors were traceable for a longer period than previously acknowledged.
    Type of Medium: Online Resource
    ISSN: 1660-3796 , 1660-3818
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 2100533-3
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