KOBV Portal

Hits per page

hits 1 - 10 | 45 hits

Sorting

Online Resource

Colombian surgical outcomes study insights on perioperative mortality rate, a main indicator of the lancet commission on global surgery – a prospective cohort study

Pérez Rivera, Carlos J. ; Lozano-Suárez, Nicolás ; Velandia-Sánchez, Alejandro ; [et al.]

Elsevier BV ; 2024

In: The Lancet Regional Health - Americas Vol. 38 ( 2024-10), p. 100862-

add to watchlist on the watchlist

Details

In: The Lancet Regional Health - Americas, Elsevier BV, Vol. 38 ( 2024-10), p. 100862-

Type of Medium: Online Resource

ISSN: 2667-193X

URL: Article

DOI: 10.1016/j.lana.2024.100862

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 3096925-6

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

Pan, Hongchao ; Peto, Richard ; Henao Restrepo, Ana Maria ; [et al.]

Elsevier BV ; 2022

In: The Lancet Vol. 399, No. 10339 ( 2022-05), p. 1941-1953

add to watchlist on the watchlist

Details

In: The Lancet, Elsevier BV, Vol. 399, No. 10339 ( 2022-05), p. 1941-1953

Type of Medium: Online Resource

ISSN: 0140-6736

URL: Article

DOI: 10.1016/S0140-6736(22)00519-0

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2067452-1

detail.hit.zdb_id: 3306-6

detail.hit.zdb_id: 1476593-7

SSG: 5,21

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Estrés en la Carrera de Ingeniería Civil

Espinosa, Jennifer ; Ochoa, Karla ; Saavedra, María ; [et al.]

Universidad Tecnologica de Panama ; 2020

In: Revista de Iniciación Científica Vol. 5, No. 2 ( 2020-03-23), p. 90-95

add to watchlist on the watchlist

Details

In: Revista de Iniciación Científica, Universidad Tecnologica de Panama, Vol. 5, No. 2 ( 2020-03-23), p. 90-95

Abstract: Este estudio tuvo como objetivo identificar en qué año de la carrera de Ingeniería Civil se genera más estrés en los estudiantes universitarios. El estudio se realizó durante el primer semestre 2019 de la Universidad Tecnológica de Panamá. Para conocer en qué año se generó el mayor nivel de estrés se le aplicó una encuesta a una muestra representativa de estudiantes de cada año donde se analizó diferentes puntos relativos a reacciones físicas, psicológicas y cognitivas generadas por estrés, estresores y mecanismos de afrontamientos. Debido a los resultados encontrados, se concluyó que el año en el cual los estudiantes generan más estrés es el cuarto año de la carrera universitaria, destacándose diferentes estresores como, sobrecarga de tareas y trabajos, tiempo limitado para trabajos y la evaluación por parte de los profesores, y los mecanismos de afrontamiento más utilizados fueron la elaboración de un plan y ejecución de sus tareas, y la habilidad de asertividad.

Type of Medium: Online Resource

ISSN: 2413-6786 , 2412-0464

URL: Article

DOI: 10.33412/rev-ric.v5.2.2510

Language: Unknown

Publisher: Universidad Tecnologica de Panama

Publication Date: 2020

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico

Saavedra-Rodriguez, Karla ; Maloof, Farah Vera ; Campbell, Corey L. ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Scientific Reports Vol. 8, No. 1 ( 2018-04-30)

add to watchlist on the watchlist

Details

In: Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-04-30)

Abstract: Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and effective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larval and adult populations. Insecticidal control of Ae. aegypti is challenging, due to a recent rapid global increase in knockdown-resistance (kdr) to pyrethroid insecticides. Widespread, heavy use of pyrethroid space-sprays has created an immense selection pressure for kdr, which is primarily under the control of the voltage-gated sodium channel gene ( vgsc ). To date, eleven replacements in vgsc have been discovered, published and shown to be associated with pyrethroid resistance to varying degrees. In Mexico, F1,534C and V1,016I have co-evolved in the last 16 years across Ae. aegypti populations. Recently, a novel replacement V410L was identified in Brazil and its effect on vgsc was confirmed by electrophysiology. Herein, we screened V410L in 25 Ae. aegypti historical collections from Mexico, the first heterozygote appeared in 2002 and frequencies have increased in the last 16 years alongside V1,016I and F1,534C. Knowledge of the specific vgsc replacements and their interaction to confer resistance is essential to predict and to develop strategies for resistance management.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-018-25222-0

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 2615211-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Insecticide resistance in Aedes aegypti from Tapachula, Mexico: Spatial variation and response to historical insecticide use

Solis-Santoyo, Francisco ; Rodriguez, Americo D. ; Penilla-Navarro, R. Patricia ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Neglected Tropical Diseases Vol. 15, No. 9 ( 2021-9-27), p. e0009746-

add to watchlist on the watchlist

Details

In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 9 ( 2021-9-27), p. e0009746-

Abstract: Insecticide use continues as the main strategy to control Aedes aegypti , the vector of dengue, Zika, chikungunya, and yellow fever. In the city of Tapachula, Mexico, mosquito control programs switched from pyrethroids to organophosphates for outdoor spatial spraying in 2013. Additionally, the spraying scheme switched from total coverage to focused control, prioritizing areas with higher entomological-virological risk. Five years after this strategy had been implemented, we evaluated the status and variability of insecticide resistance among Ae . aegypti collected at 26 sites in Tapachula. Methodology/Principal findings We determined the lethal concentrations at 50% of the tested populations (LC 50 ) using a bottle bioassay, and then, we calculated the resistance ratio (RR) relative to the susceptible New Orleans strain. Permethrin and deltamethrin (pyrethroids), chlorpyrifos and malathion (organophosphates), and bendiocarb (carbamate) were tested. The frequencies of the substitutions V1016I and F1534C, which are in the voltage-gated sodium channel and confer knockdown-resistance ( kdr ) to pyrethroid insecticides, were calculated. Despite 5 years having passed since the removal of pyrethroids from the control programs, Ae . aegypti remained highly resistant to permethrin and deltamethrin (RR 〉 10-fold). In addition, following 5 years of chlorpyrifos use, mosquitoes at 15 of 26 sites showed moderate resistance to chlorpyrifos (5- to 10-fold), and the mosquitoes from one site were highly resistant. All sites had low resistance to malathion ( 〈 5-fold). Resistance to bendiocarb was low at 19 sites, moderate at five, and high at two. Frequencies of the V1016I ranged from 0.16–0.71, while C1534 approached fixation at 23 sites (0.8–1). Resistance profiles and kdr allele frequencies varied across Tapachula. The variability was not associated with a spatial pattern at the scale of the sampling. Conclusion/Significance Mosquito populations respond to selection pressure at a focal scale in the field. Spatial variation across sites highlights the importance of testing multiple sites within geographical regions.

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0009746

DOI: 10.1371/journal.pntd.0009746.g001

DOI: 10.1371/journal.pntd.0009746.g002

DOI: 10.1371/journal.pntd.0009746.g003

DOI: 10.1371/journal.pntd.0009746.g004

DOI: 10.1371/journal.pntd.0009746.t001

DOI: 10.1371/journal.pntd.0009746.t002

DOI: 10.1371/journal.pntd.0009746.t003

DOI: 10.1371/journal.pntd.0009746.s001

DOI: 10.1371/journal.pntd.0009746.s002

DOI: 10.1371/journal.pntd.0009746.s003

DOI: 10.1371/journal.pntd.0009746.s004

DOI: 10.1371/journal.pntd.0009746.r001

DOI: 10.1371/journal.pntd.0009746.r002

DOI: 10.1371/journal.pntd.0009746.r003

DOI: 10.1371/journal.pntd.0009746.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2429704-5

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Association among Terminally Differentiated T Cells, Frailty, and Dependency in a Group of Cuban Centenarians

Añé-Kourí, Ana Laura ; Ledón, Nuris ; Ramos, Mercedes Bárbara ; [et al.]

S. Karger AG ; 2023

In: Gerontology Vol. 69, No. 3 ( 2023), p. 239-248

add to watchlist on the watchlist

Details

In: Gerontology, S. Karger AG, Vol. 69, No. 3 ( 2023), p. 239-248

Abstract: Introduction: Centenarians are considered a model of successful aging. Cuba exhibits one of the oldest populations in Latin America with more than two thousand centenarians. Methods: This study aimed to evaluate the immune phenotype of forty-three Cuban centenarians, their clinical characteristics such as comorbidities, frailty, body mass index, and some hemochemical parameters. Results: Centenarians had normal body mass indexes, relatively good health status, and 21.95% of them had no comorbidities; 53.6% were classified as frail, and 7% were classified as robust. In addition, 17% of centenarians were independent, and 41.46% were moderately dependent. The seroprevalence against cytomegalovirus was 100%. Concerning pro-inflammatory markers, the majority of them had very low cytokine levels and serum C-reactive protein around the normal limit. We also found the predominance of memory subsets over naive compartments in CD4+ and CD8+ T cells. Terminally differentiated CD8+CD28− T cells were higher in frail centenarians than in pre-frail, while CD8+CD57+ and CD8+EMRA T cells were higher in moderately and severely dependent individuals than in independent individuals. Severely dependent centenarians had a lower CD4+/CD8+ ratio. Conclusion: This study describes for the first time the predominance of memory subsets over naive compartments in CD4+ and CD8+ T cells, as well as its relation to frailty and/or dependency in a group of Cuban centenarians. Further studies are needed to continue understanding the natural biological aging mechanism and the relationship between terminally differentiated lymphocytes and inflammaging in the context of extreme longevity.

Type of Medium: Online Resource

ISSN: 0304-324X , 1423-0003

URL: Article

DOI: 10.1159/000525062

Language: English

Publisher: S. Karger AG

Publication Date: 2023

detail.hit.zdb_id: 1482689-6

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Loss of pyrethroid resistance in newly established laboratory colonies of Aedes aegypti

Vera-Maloof, Farah Z. ; Saavedra-Rodriguez, Karla ; Penilla-Navarro, Rosa P. ; [et al.]

Public Library of Science (PLoS) ; 2020

In: PLOS Neglected Tropical Diseases Vol. 14, No. 3 ( 2020-3-16), p. e0007753-

add to watchlist on the watchlist

Details

In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 14, No. 3 ( 2020-3-16), p. e0007753-

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0007753

DOI: 10.1371/journal.pntd.0007753.g001

DOI: 10.1371/journal.pntd.0007753.g002

DOI: 10.1371/journal.pntd.0007753.g003

DOI: 10.1371/journal.pntd.0007753.g004

DOI: 10.1371/journal.pntd.0007753.g005

DOI: 10.1371/journal.pntd.0007753.g006

DOI: 10.1371/journal.pntd.0007753.g007

DOI: 10.1371/journal.pntd.0007753.g008

DOI: 10.1371/journal.pntd.0007753.t001

DOI: 10.1371/journal.pntd.0007753.t002

DOI: 10.1371/journal.pntd.0007753.t003

DOI: 10.1371/journal.pntd.0007753.t004

DOI: 10.1371/journal.pntd.0007753.t005

DOI: 10.1371/journal.pntd.0007753.t006

DOI: 10.1371/journal.pntd.0007753.t007

DOI: 10.1371/journal.pntd.0007753.s001

DOI: 10.1371/journal.pntd.0007753.s002

DOI: 10.1371/journal.pntd.0007753.s003

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2020

detail.hit.zdb_id: 2429704-5

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Aedes aegypti, Ae. albopictus and Culex quinquefasciatus Adults Found Coexisting in Urban and Semiurban Dwellings of Southern Chiapas, Mexico

Lopez-Solis, Alma D. ; Solis-Santoyo, Francisco ; Saavedra-Rodriguez, Karla ; [et al.]

MDPI AG ; 2023

In: Insects Vol. 14, No. 6 ( 2023-06-17), p. 565-

add to watchlist on the watchlist

Details

In: Insects, MDPI AG, Vol. 14, No. 6 ( 2023-06-17), p. 565-

Abstract: Tapachula, Mexico, a tropical city, is an endemic area for dengue, in addition to several outbreaks in the last decade with chikungunya and zika. As part of the migratory corridor from Central to North America and the risks of scattered infectious diseases that this implies, the identification and distribution of potential disease vectors in and around residential areas are essential in terms of entomological surveillance for the prevention of disease outbreaks. The identification of mosquito species of medical importance coexisting in houses and cemeteries in Tapachula and two semiurban sites in southern Chiapas was investigated. Adult mosquitoes were collected from May to December 2018, resting inside and outside houses and in the tombstones and fallen tree leaves in cemeteries. A total of 10,883 mosquitoes belonging to three vector species were collected across 20 sites; 6738 were from neighborhood houses, of which 55.4% were Culex quinquefasciatus, 41.6% Aedes aegypti, and 2.9% Ae. albopictus. Aedes aegypti was the most common mosquito resting inside houses (56.7%), while Ae. albopictus and Cx. quinquefasciatus were mostly found resting outside houses (75.7%). In the cemeteries, Cx. quinquefasciatus (60.8%) and Ae. albopictus (37.3%) were the most abundant, while Ae. aegypti (1.9%) was the least abundant. This is the first report to identify adults of three major disease vector species coexisting in the domestic environment of urban and semiurban sites and Ae. albopictus adult resting inside of urban houses in Mexico. It would be opportune to consider comprehensive strategies that can be applied in this region to control the three species at the same time and avoid outbreaks of the diseases they transmit.

Type of Medium: Online Resource

ISSN: 2075-4450

URL: Article

DOI: 10.3390/insects14060565

Language: English

Publisher: MDPI AG

Publication Date: 2023

detail.hit.zdb_id: 2662247-6

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Permethrin resistance in Aedes aegypti: Genomic variants that confer knockdown resistance, recovery, and death

Saavedra-Rodriguez, Karla ; Campbell, Corey L. ; Lozano, Saul ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Genetics Vol. 17, No. 6 ( 2021-6-17), p. e1009606-

add to watchlist on the watchlist

Details

In: PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 6 ( 2021-6-17), p. e1009606-

Abstract: Pyrethroids are one of the few classes of insecticides available to control Aedes aegypti , the major vector of dengue, chikungunya, and Zika viruses. Unfortunately, evolving mechanisms of pyrethroid resistance in mosquito populations threaten our ability to control disease outbreaks. Two common pyrethroid resistance mechanisms occur in Ae . aegypti : 1) knockdown resistance, which involves amino acid substitutions at the pyrethroid target site—the voltage-gated sodium channel (VGSC)—and 2) enhanced metabolism by detoxification enzymes. When a heterogeneous population of mosquitoes is exposed to pyrethroids, different responses occur. During exposure, a proportion of mosquitoes exhibit immediate knockdown, whereas others are not knocked-down and are designated knockdown resistant (kdr). When these individuals are removed from the source of insecticide, the knocked-down mosquitoes can either remain in this status and lead to dead or recover within a few hours. The proportion of these phenotypic responses is dependent on the pyrethroid concentration and the genetic background of the population tested. In this study, we sequenced and performed pairwise genome comparisons between kdr, recovered, and dead phenotypes in a pyrethroid-resistant colony from Tapachula, Mexico. We identified single-nucleotide polymorphisms (SNPs) associated with each phenotype and identified genes that are likely associated with the mechanisms of pyrethroid resistance, including detoxification, the cuticle, and insecticide target sites. We identified high association between kdr and mutations at VGSC and moderate association with additional insecticide target site, detoxification, and cuticle protein coding genes. Recovery was associated with cuticle proteins, the voltage-dependent calcium channel, and a different group of detoxification genes. We provide a list of detoxification genes under directional selection in this field-resistant population. Their functional roles in pyrethroid metabolism and their potential uses as genomic markers of resistance require validation.

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1009606

DOI: 10.1371/journal.pgen.1009606.g001

DOI: 10.1371/journal.pgen.1009606.g002

DOI: 10.1371/journal.pgen.1009606.g003

DOI: 10.1371/journal.pgen.1009606.g004

DOI: 10.1371/journal.pgen.1009606.t001

DOI: 10.1371/journal.pgen.1009606.t002

DOI: 10.1371/journal.pgen.1009606.t003

DOI: 10.1371/journal.pgen.1009606.t004

DOI: 10.1371/journal.pgen.1009606.s001

DOI: 10.1371/journal.pgen.1009606.s002

DOI: 10.1371/journal.pgen.1009606.s003

DOI: 10.1371/journal.pgen.1009606.s004

DOI: 10.1371/journal.pgen.1009606.s005

DOI: 10.1371/journal.pgen.1009606.s006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2186725-2

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Evaluation of commercial aerosol insecticides for control of Aedes aegypti susceptible or resistant to pyrethroids

López-Solis, Alma Delia ; Janich, Ashley J. ; Solis-Santoyo, Francisco ; [et al.]

Instituto Nacional de Salud Publica ; 2023

In: Salud Pública de México Vol. 65, No. 2 mar-abr ( 2023-03-10), p. 151-159

add to watchlist on the watchlist

Details

In: Salud Pública de México, Instituto Nacional de Salud Publica, Vol. 65, No. 2 mar-abr ( 2023-03-10), p. 151-159

Abstract: Objective. To evaluate indoor use of commercial aerosols for dengue vector mosquito control, and estimate the number of treatable houses per can. Materials and methods. Four aerosol products containing combinations of pyrethroids (two containing propoxur and one containing synergists too), were evaluated with mosquitoes in a room of a Tapachulastyle house. Eight cages containing 20 insecticide susceptible or resistant females were hung from tripods, another set was placed in sheltered areas of the room. From the entrance of the room, one of 4-9 concentrations was sprayed for each aerosol, leaving the mosquitoes for 30 min after sprayed. Mortality was recorded after 24 h and lethal concentrations were calculated. Results. Aerosol A had the highest LC50, with 0.308 g for mosquitoes hanging from tripods and 0.453 g for sheltered mosquitoes; followed by aerosols C, D and B, with statistical differences between types of exposure. Conclusions. Aerosols B-D could spray 20-25 3-room houses (56 m3-room), killing all resistant mosquitoes. Aerosols may become a good tool for indoor mosquito control, if the optimal concentration and correct spray method are used.

Type of Medium: Online Resource

ISSN: 1606-7916 , 0036-3634

URL: Article

DOI: 10.21149/14232

Language: Unknown

Publisher: Instituto Nacional de Salud Publica

Publication Date: 2023

detail.hit.zdb_id: 2060310-1

SSG: 7,36

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 45 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg