In:
Annual Review of Immunology, Annual Reviews, Vol. 28, No. 1 ( 2010-03-01), p. 79-105
Abstract:
T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called immunological kinapses or prolonged contacts from stable junctions called immunological synapses. Kinapses operate in the steady state to allow referencing to self-peptide-MHC (pMHC) and searching for pathogen-derived pMHC. Synapses are induced by T cell receptor (TCR) interactions with agonist pMHC under specific conditions and correlate with robust immune responses that generate effector and memory T cells. High-resolution imaging has revealed that the synapse is highly coordinated, integrating cell adhesion, TCR recognition of pMHC complexes, and an array of activating and inhibitory ligands to promote or prevent T cell signaling. In this review, we examine the molecular components, geometry, and timing underlying kinapses and synapses. We integrate recent molecular and physiological data to provide a synthesis and suggest ways forward.
Type of Medium:
Online Resource
ISSN:
0732-0582
,
1545-3278
DOI:
10.1146/immunol.2010.28.issue-1
DOI:
10.1146/annurev-immunol-030409-101308
Language:
English
Publisher:
Annual Reviews
Publication Date:
2010
detail.hit.zdb_id:
1470451-1
SSG:
12
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