In:
Journal of Surgical Oncology, Wiley, Vol. 109, No. 7 ( 2014-06), p. 659-664
Abstract:
Preoperative chemoradiotherapy (CRT) significantly decreases local recurrence in advanced rectal cancer. We studied whether the degree of tumor shrinkage can be used as a predictor of histologic response. Methods The subjects were 114 patients with locally advanced rectal cancer who underwent total mesorectal excision after receiving radiotherapy combined with uracil/tegafur (UFT) or S‐1. The degree of tumor shrinkage based on barium enema examination and magnetic resonance imaging (MRI) were assessed before CRT and immediately before surgery. Results A histologic complete response (ypCR), histologic marked regression, T and N downstaging were associated with significantly higher tumor‐shrinkage rates on barium enema ( P 〈 0.01, P 〈 0.01, P 〈 0.01, and P 〈 0.01, respectively) as well as on MRI ( P 〈 0.01, P 〈 0.01, P 〈 0.01, and P = 0.01, respectively). On multivariate analysis, ypCR and histologic marked regression were significantly related only to tumor‐shrinkage rates on barium enema ( P 〈 0.01 and P 〈 0.01, respectively), and were not related to tumor‐shrinkage rates on MRI. Conclusions The degree of tumor shrinkage is closely related to the final histologic response. Two‐dimensionally evaluated tumor‐shrinkage rates based on barium enema are adequate for the prediction of histologic response. J. Surg. Oncol 2014; 109:659–664 . © 2013 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
0022-4790
,
1096-9098
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1475314-5
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