In:
Journal of Hepato-Biliary-Pancreatic Sciences, Wiley, Vol. 17, No. 6 ( 2010-11), p. 865-870
Abstract:
Gallbladder cancer occurs frequently in patients with pancreaticobiliary maljunction due to pancreatobiliary reflux. Pancreatobiliary reflux is also detected in some patients with a relatively long common channel. This study aimed to clarify the correlation between pancreatobiliary reflux and the length of a common channel. Methods Two hundred and three patients, in whom both the length of a common channel and amylase level in the bile were measured, were enrolled from nine centers. Results Bile amylase level was correlated with the length of a common channel ( p 〈 0.01). The minimum length of a common channel that could induce a markedly elevated amylase level in the bile ( 〉 1,000 mg/dl) was determined as 5 mm. We redefined high confluence of pancreatobiliary ducts (HCPBD) as cases with a common channel ≥5 mm, in which the communication between the pancreatic and bile ducts was occluded with the sphincter contraction. Gallbladder cancer was found in 20% of 56 redefined HCPBD patients. Bile amylase level 〉 1,000 mg/dl and biliopancreatic reflux were detected in 79 and 95% of the patients, respectively. Conclusions Patients with a common channel ≥5 mm (redefined HCPBD) should be monitored for the development of gallbladder cancer, as they frequently showed significant pancreatobiliary reflux.
Type of Medium:
Online Resource
ISSN:
1868-6974
,
1868-6982
DOI:
10.1007/s00534-010-0282-4
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
2536390-6
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