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The world first two cases of severe fever with thrombocytopenia syndrome: An epidemiological study in Nagasaki, Japan

Kurihara, Shintaro ; Satoh, Akira ; Yu, Fuxun ; [et al.]

Elsevier BV ; 2016

In: Journal of Infection and Chemotherapy Vol. 22, No. 7 ( 2016-07), p. 461-465

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In: Journal of Infection and Chemotherapy, Elsevier BV, Vol. 22, No. 7 ( 2016-07), p. 461-465

Type of Medium: Online Resource

ISSN: 1341-321X

URL: Article

DOI: 10.1016/j.jiac.2016.04.001

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 1481768-8

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Detection of viral RNA in diverse body fluids in an SFTS patient with encephalopathy, gastrointestinal bleeding and pneumonia: a case report and literature review

Akagi, Kazumasa ; Miyazaki, Taiga ; Oshima, Kazuhiro ; [et al.]

Springer Science and Business Media LLC ; 2020

In: BMC Infectious Diseases Vol. 20, No. 1 ( 2020-12)

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In: BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)

Abstract: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that commonly has a lethal course caused by the tick-borne Huaiyangshan banyang virus [former SFTS virus (SFTSV)]. The viral load in various body fluids in SFTS patients and the best infection control measure for SFTS patients have not been fully established. Case presentation A 79-year-old man was bitten by a tick while working in the bamboo grove in Nagasaki Prefecture in the southwest part of Japan. Due to the occurrence of impaired consciousness, he was referred to Nagasaki University Hospital for treatment. The serum sample tested positive for SFTSV-RNA in the genome amplification assay, and he was diagnosed with SFTS. Furthermore, SFTSV-RNA was detected from the tick that had bitten the patient. He was treated with multimodal therapy, including platelet transfusion, antimicrobials, antifungals, steroids, and continuous hemodiafiltration. His respiration was assisted with mechanical ventilation. On day 5, taking the day on which he was hospitalized as day 0, serum SFTSV-RNA levels reached a peak and then decreased. However, the cerebrospinal fluid collected on day 13 was positive for SFTSV-RNA. In addition, although serum SFTSV-RNA levels decreased below the detectable level on day 16, he was diagnosed with pneumonia with computed tomography. SFTSV-RNA was detected in the bronchoalveolar lavage fluid on day 21. By day 31, he recovered consciousness completely. The pneumonia improved by day 51, but SFTSV-RNA in the sputum remained positive for approximately 4 months after disease onset. Strict countermeasures against droplet/contact infection were continuously conducted. Conclusions Even when SFTSV genome levels become undetectable in the serum of SFTS patients in the convalescent phase, the virus genome remains in body fluids and tissues. It may be possible that body fluids such as respiratory excretions become a source of infection to others; thus, careful infection control management is needed.

Type of Medium: Online Resource

ISSN: 1471-2334

URL: Article

DOI: 10.1186/s12879-020-05012-8

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2041550-3

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A multicenter non-randomized, uncontrolled single arm trial for evaluation of the efficacy and the safety of the treatment with favipiravir for patients with severe fever with thrombocytopenia syndrome

Suemori, Koichiro ; Saijo, Masayuki ; Yamanaka, Atsushi ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Neglected Tropical Diseases Vol. 15, No. 2 ( 2021-2-22), p. e0009103-

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In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 2 ( 2021-2-22), p. e0009103-

Abstract: Severe fever with thrombocytopenia syndrome (SFTS) is a bunyavirus infection with high mortality. Favipiravir has shown effectiveness in preventing and treating SFTS virus (SFTSV) infection in animal models. A multicenter non-randomized, uncontrolled single arm trial was conducted to collect data on the safety and the effectiveness of favipiravir in treatment of SFTS patients. All participants received favipiravir orally (first-day loading dose of 1800 mg twice a day followed by 800 mg twice a day for 7–14 days in total). SFTSV RT-PCR and biochemistry tests were performed at designated time points. Outcomes were 28-day mortality, clinical improvement, viral load evolution, and adverse events (AEs). Twenty-six patients were enrolled, of whom 23 were analyzed. Four of these 23 patients died of multi-organ failure within one week (28-day mortality rate: 17.3%). Oral favipiravir was well tolerated in the surviving patients. AEs (abnormal hepatic function and insomnia) occurred in about 20% of the patients. Clinical symptoms improved in all patients who survived from a median of day 2 to day10. SFTSV RNA levels in the patients who died were significantly higher than those in the survivors (p = 0.0029). No viral genomes were detectable in the surviving patients a median of 8 days after favipiravir administration. The 28-day mortality rate in this study was lower than those of the previous studies in Japan. The high frequency of hepatic dysfunction as an AE was observed. However, it was unclear whether this was merely a side effect of favipiravir, because liver disorders are commonly seen in SFTS patients. The results of this trial support the effectiveness of favipiravir for patients with SFTS.

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0009103

DOI: 10.1371/journal.pntd.0009103.g001

DOI: 10.1371/journal.pntd.0009103.g002

DOI: 10.1371/journal.pntd.0009103.g003

DOI: 10.1371/journal.pntd.0009103.g004

DOI: 10.1371/journal.pntd.0009103.t001

DOI: 10.1371/journal.pntd.0009103.t002

DOI: 10.1371/journal.pntd.0009103.t003

DOI: 10.1371/journal.pntd.0009103.t004

DOI: 10.1371/journal.pntd.0009103.t005

DOI: 10.1371/journal.pntd.0009103.t006

DOI: 10.1371/journal.pntd.0009103.s001

DOI: 10.1371/journal.pntd.0009103.s002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2429704-5

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Respiratory Tract Infection and Respiratory Syncytial Virus in Young Infants

SAIJO, Masayuki ; YAMAMOTO, Michio ; SAIJO, Harumi ; [et al.]

The Japanese Association for Infectious Diseases ; 1995

In: Journal of the Japanese Association for Infectious Diseases Vol. 69, No. 1 ( 1995), p. 68-72

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In: Journal of the Japanese Association for Infectious Diseases, The Japanese Association for Infectious Diseases, Vol. 69, No. 1 ( 1995), p. 68-72

Type of Medium: Online Resource

ISSN: 1884-569X , 0387-5911

Uniform Title: 幼若乳児の気道感染症とRespiratory Syncytial Virus

URL: Article

DOI: 10.11150/kansenshogakuzasshi1970.69.68

Language: English , Japanese

Publisher: The Japanese Association for Infectious Diseases

Publication Date: 1995

detail.hit.zdb_id: 2622004-0

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Thrombocytopenic Purpura Associated with Primary Human Herpesvirus-6 Infection

SAIJO, Masayuki ; YAMAMOTO, Michio ; SAIJO, Harumi ; [et al.]

The Japanese Association for Infectious Diseases ; 1995

In: Journal of the Japanese Association for Infectious Diseases Vol. 69, No. 3 ( 1995), p. 316-319

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In: Journal of the Japanese Association for Infectious Diseases, The Japanese Association for Infectious Diseases, Vol. 69, No. 3 ( 1995), p. 316-319

Type of Medium: Online Resource

ISSN: 1884-569X , 0387-5911

Uniform Title: 血清学的に証明されたHuman herpesvirus-6初感染に合併した血小板減少性紫斑病の1例

URL: Article

DOI: 10.11150/kansenshogakuzasshi1970.69.316

Language: English , Japanese

Publisher: The Japanese Association for Infectious Diseases

Publication Date: 1995

detail.hit.zdb_id: 2622004-0

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THROMBOCYTOPENIC PURPURA ASSOCIATED WITH PRIMRY HUMAN HERPESVIRUS 6 INFECTION

Saijo, Masayuki ; Saijo, Harumi ; Yamamoto, Michio ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 1995

In: The Pediatric Infectious Disease Journal Vol. 14, No. 5 ( 1995-05), p. 405-

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In: The Pediatric Infectious Disease Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 14, No. 5 ( 1995-05), p. 405-

Type of Medium: Online Resource

ISSN: 0891-3668

URL: Article

DOI: 10.1097/00006454-199505000-00022

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 1995

detail.hit.zdb_id: 2020216-7

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Sensitive and Specific PCR Systems for Detection of Both Chinese and Japanese Severe Fever with Thrombocytopenia Syndrome Virus Strains and Prediction of Patient Survival Based on Viral Load

Yoshikawa, Tomoki ; Fukushi, Shuetsu ; Tani, Hideki ; [et al.]

American Society for Microbiology ; 2014

In: Journal of Clinical Microbiology Vol. 52, No. 9 ( 2014-09), p. 3325-3333

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In: Journal of Clinical Microbiology, American Society for Microbiology, Vol. 52, No. 9 ( 2014-09), p. 3325-3333

Abstract: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high case fatality risk and is caused by the SFTS virus (SFTSV). A retrospective study conducted after the first identification of an SFTS patient in Japan revealed that SFTS is endemic to the region, and the virus exists indigenously in Japan. Since the nucleotide sequence of Japanese SFTSV strains contains considerable differences compared with that of Chinese strains, there is an urgent need to establish a sensitive and specific method capable of detecting the Chinese and Japanese strains of SFTSV. A conventional one-step reverse transcription-PCR (RT-PCR) (cvPCR) method and a quantitative one-step RT-PCR (qPCR) method were developed to detect the SFTSV genome. Both cvPCR and qPCR detected a Chinese SFTSV strain. Forty-one of 108 Japanese patients suspected of having SFTS showed a positive reaction by cvPCR. The results from the samples of 108 Japanese patients determined by the qPCR method were in almost complete agreement with those determined by cvPCR. The analyses of the viral copy number level in the patient blood samples at the acute phase determined by qPCR in association with the patient outcome confirmed that the SFTSV RNA load in the blood of the nonsurviving patients was significantly higher than that of the surviving patients. Therefore, the cvPCR and qPCR methods developed in this study can provide a powerful means for diagnosing SFTS. In addition, the detection of the SFTSV genome level by qPCR in the blood of the patients at the acute phase may serve as an indicator to predict the outcome of SFTS.

Type of Medium: Online Resource

ISSN: 0095-1137 , 1098-660X

URL: Article

DOI: 10.1128/JCM.00742-14

RVK:

XA 10000

Language: English

Publisher: American Society for Microbiology

Publication Date: 2014

detail.hit.zdb_id: 1498353-9

SSG: 12

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The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan

Takahashi, Toru ; Maeda, Ken ; Suzuki, Tadaki ; [et al.]

Oxford University Press (OUP) ; 2014

In: The Journal of Infectious Diseases Vol. 209, No. 6 ( 2014-3-15), p. 816-827

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In: The Journal of Infectious Diseases, Oxford University Press (OUP), Vol. 209, No. 6 ( 2014-3-15), p. 816-827

Type of Medium: Online Resource

ISSN: 1537-6613 , 0022-1899

URL: Article

DOI: 10.1093/infdis/jit603

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2014

detail.hit.zdb_id: 1473843-0

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RIG-I-Like Receptor and Toll-Like Receptor Signaling Pathways Cause Aberrant Production of Inflammatory Cytokines/Chemokines in a Severe Fever with Thrombocytopenia Syndrome Virus Infection Mouse Model

Yamada, Shintaro ; Shimojima, Masayuki ; Narita, Ryo ; [et al.]

American Society for Microbiology ; 2018

In: Journal of Virology Vol. 92, No. 13 ( 2018-07)

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In: Journal of Virology, American Society for Microbiology, Vol. 92, No. 13 ( 2018-07)

Abstract: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a tick-borne phlebovirus of the family Bunyaviridae , SFTS virus (SFTSV). Wild-type and type I interferon (IFN-I) receptor 1-deficient (IFNAR1 −/− ) mice have been established as nonlethal and lethal models of SFTSV infection, respectively. However, the mechanisms of IFN-I production in vivo and the factors causing the lethal disease are not well understood. Using bone marrow-chimeric mice, we found that IFN-I signaling in hematopoietic cells was essential for survival of lethal SFTSV infection. The disruption of IFN-I signaling in hematopoietic cells allowed an increase in viral loads in serum and produced an excess of multiple inflammatory cytokines and chemokines. The production of IFN-I and inflammatory cytokines was abolished by deletion of the signaling molecules IPS-1 and MyD88, essential for retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) and Toll-like receptor (TLR) signaling, respectively. However, IPS-1 −/− MyD88 −/− mice exhibited resistance to lethal SFTS with a moderate viral load in serum. Taken together, these results indicate that adequate activation of RLR and TLR signaling pathways under low to moderate levels of viremia contributed to survival through the IFN-I-dependent antiviral response during SFTSV infection, whereas overactivation of these signaling pathways under high levels of viremia resulted in abnormal induction of multiple inflammatory cytokines and chemokines, causing the lethal disease. IMPORTANCE SFTSV causes a severe infectious disease in humans, with a high fatality rate of 12 to 30%. To know the pathogenesis of the virus, we need to clarify the innate immune response as a front line of defense against viral infection. Here, we report that a lethal animal model showed abnormal induction of multiple inflammatory cytokines and chemokines by an uncontrolled innate immune response, which triggered the lethal SFTS. Our findings suggest a new strategy to target inflammatory humoral factors to treat patients with severe SFTS. Furthermore, this study may help the investigation of other tick-borne viruses.

Type of Medium: Online Resource

ISSN: 0022-538X , 1098-5514

URL: Article

DOI: 10.1128/JVI.02246-17

Language: English

Publisher: American Society for Microbiology

Publication Date: 2018

detail.hit.zdb_id: 1495529-5

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Analysis of Lujo Virus Cell Entry using Pseudotype Vesicular Stomatitis Virus

Tani, Hideki ; Iha, Koichiro ; Shimojima, Masayuki ; [et al.]

American Society for Microbiology ; 2014

In: Journal of Virology Vol. 88, No. 13 ( 2014-07), p. 7317-7330

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In: Journal of Virology, American Society for Microbiology, Vol. 88, No. 13 ( 2014-07), p. 7317-7330

Abstract: Several arenaviruses are known to cause viral hemorrhagic fever (VHF) in sub-Saharan Africa and South America, where VHF is a major public health and medical concern. The biosafety level 4 categorization of these arenaviruses restricts their use and has impeded biological studies, including therapeutic drug and/or vaccine development. Due to difficulties associated with handling live viruses, pseudotype viruses, which transiently bear arenavirus envelope proteins based on vesicular stomatitis virus (VSV) or retrovirus, have been developed as surrogate virus systems. Here, we report the development of a pseudotype VSV bearing each envelope protein of various species of arenaviruses (AREpv), including the newly identified Lujo virus (LUJV) and Chapare virus. Pseudotype arenaviruses generated in 293T cells exhibited high infectivity in various mammalian cell lines. The infections by New World and Old World AREpv were dependent on their receptors (human transferrin receptor 1 [hTfR1] and α-dystroglycan [αDG] , respectively). However, infection by pseudotype VSV bearing the LUJV envelope protein (LUJpv) occurred independently of hTfR1 and αDG, indicating that LUJpv utilizes an unidentified receptor. The pH-dependent endocytosis of AREpv was confirmed by the use of lysosomotropic agents. The fusion of cells expressing these envelope proteins, except for those expressing the LUJV envelope protein, was induced by transient treatment at low pH values. LUJpv infectivity was inhibited by U18666A, a cholesterol transport inhibitor. Furthermore, the infectivity of LUJpv was significantly decreased in the Niemann-Pick C1 (NPC1)-deficient cell line, suggesting the necessity for NPC1 activity for efficient LUJpv infection. IMPORTANCE LUJV is a newly identified arenavirus associated with a VHF outbreak in southern Africa. Although cell entry for many arenaviruses has been studied, cell entry for LUJV has not been characterized. In this study, we found that LUJpv utilizes neither αDG nor hTfR1 as a receptor and found unique characteristics of LUJV glycoprotein in membrane fusion and cell entry. Proper exclusion of cholesterol or some kinds of lipids may play important roles in LUJpv cell entry.

Type of Medium: Online Resource

ISSN: 0022-538X , 1098-5514

URL: Article

DOI: 10.1128/JVI.00512-14

Language: English

Publisher: American Society for Microbiology

Publication Date: 2014

detail.hit.zdb_id: 1495529-5

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