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1

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The interaction between physical frailty and prognostic impact of heart failure medication in elderly patients

Abe, Takuro ; Jujo, Kentaro ; Maeda, Daichi ; [et al.]

Wiley ; 2023

In: ESC Heart Failure Vol. 10, No. 3 ( 2023-06), p. 1698-1705

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In: ESC Heart Failure, Wiley, Vol. 10, No. 3 ( 2023-06), p. 1698-1705

Abstract: Frailty is highly prevalent and associated with poor prognoses in elderly patients with heart failure (HF). However, the potential effects of physical frailty on the benefits of HF medications in elderly patients with HF are unclear. We aimed to determine the influence of physical frailty on the prognosis of HF medications in elderly patients with HF with reduced and mildly reduced ejection fraction (HFr/mrEF). Methods and results From the combined HF database of the FRAGILE‐HF and Kitasato cohorts, hospitalized HF patients with a left ventricular ejection fraction 〈 50% and age ≥ 65 years were analysed. Patients treated with or without renin‐angiotensin‐aldosterone system inhibitors (RAASi) and beta‐blockers at discharge were compared. Physical frailty was defined by the presence of ≥3 items on the Japanese version of the Cardiovascular Health Study criteria. The primary endpoint was all‐cause mortality rate. Among the 1021 enrolled patients, 604 patients (59%) received both RAASi and beta‐blockers, and 604 patients (59%) were diagnosed as physically frail. Patients receiving both RAASi and beta‐blockers showed a significantly lower 1 year mortality than those not receiving either, even after adjusting for covariates (hazard ratio: 0.50, 95% confidence interval: 0.34–0.75). This beneficial effect of both medications on 1 year mortality was comparable between patients with and without physical frailty (hazard ratio: 0.53 and 0.51, respectively; P for interaction = 0.77). Conclusions The presence of physical frailty did not interact with the beneficial prognostic impact of RAASi and beta‐blocker combination therapy in elderly patients with HFr/mrEF.

Type of Medium: Online Resource

ISSN: 2055-5822 , 2055-5822

URL: Issue

URL: Article

DOI: 10.1002/ehf2.v10.3

DOI: 10.1002/ehf2.14114

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 2814355-3

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2

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Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Kondo, Takayuki ; Hara, Norikazu ; Koyama, Satoshi ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Nature Aging Vol. 2, No. 2 ( 2022-02-17), p. 125-139

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In: Nature Aging, Springer Science and Business Media LLC, Vol. 2, No. 2 ( 2022-02-17), p. 125-139

Type of Medium: Online Resource

ISSN: 2662-8465

URL: Article

DOI: 10.1038/s43587-021-00158-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 3029419-8

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3

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Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Masuda, Hiroki ; Mori, Masahiro ; Hirano, Shigeki ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Scientific Reports Vol. 13, No. 1 ( 2023-08-03)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-08-03)

Abstract: We aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer’s Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. − 0.14, P = 0.018). The maximum spinal cord lesion length negatively correlated with NWV at baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho = − 0.41, P = 0.027). The annualized NWV atrophy rate negatively correlated with the time between initiation of persistent prednisolone usage and baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho = − 0.43, P = 0.019). Patients with AQP4 + NMOSD had a greater annualized NWV atrophy rate than HCs. Suppressing disease activity may prevent brain atrophy in patients with AQP4 + NMOSD.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-023-38893-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2615211-3

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A high- T C heavy rare earth monoxide semiconductor TbO with a more than half-filled 4f orbital

Sasaki, Satoshi ; Oka, Daichi ; Kaminaga, Kenichi ; [et al.]

Royal Society of Chemistry (RSC) ; 2022

In: Dalton Transactions Vol. 51, No. 43 ( 2022), p. 16648-16652

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In: Dalton Transactions, Royal Society of Chemistry (RSC), Vol. 51, No. 43 ( 2022), p. 16648-16652

Abstract: Terbium monoxide, TbO, with an unusual valence state of Tb 2+ ([Xe]4f 8 5d 1 ) has been known to exist as a gas phase. In this study, we report a solid phase rock-salt structured TbO in the form of an epitaxial thin film. This TbO is a narrow gap ferromagnetic semiconductor with a bandgap of ∼0.1 eV and high Curie temperature of 231 K, and exhibited negative magnetoresistance of −14% at 9 T and 2 K. Its magnetization steeply increased with the appearance of a wasp-waisted hysteresis curve significantly below the Curie temperature at about 20 K. These results suggested that both 4f and 5d magnetic sublattices were formed at a single magnetic Tb 2+ site in TbO.

Type of Medium: Online Resource

ISSN: 1477-9226 , 1477-9234

URL: Article

DOI: 10.1039/D2DT02710K

Language: English

Publisher: Royal Society of Chemistry (RSC)

Publication Date: 2022

detail.hit.zdb_id: 1472887-4

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Thickness-dependent magnetotransport properties of rocksalt NdO epitaxial thin films: observation of a ferromagnetic phase far above the Curie temperature

Saito, Daichi ; Oka, Daichi ; Kaminaga, Kenichi ; [et al.]

Royal Society of Chemistry (RSC) ; 2023

In: Journal of Materials Chemistry C Vol. 11, No. 36 ( 2023), p. 12400-12405

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In: Journal of Materials Chemistry C, Royal Society of Chemistry (RSC), Vol. 11, No. 36 ( 2023), p. 12400-12405

Abstract: We investigated magnetotransport properties of rocksalt NdO (001) epitaxial thin films with various thicknesses. For the thickness of 45 nm, the NdO thin film behaved as a ferromagnetic metal with the Curie temperature ( T C ) of 19 K as was reported recently. With decreasing film thickness down to 3 nm, the resistivity increased monotonically, and the T C was reduced. Intriguingly, 9 nm-thick and 12 nm-thick films showed non-zero remanent magnetization and anomalous Hall effect far above the T C , up to 40 K, indicating the emergence of a weak ferromagnetic phase above the T C .

Type of Medium: Online Resource

ISSN: 2050-7526 , 2050-7534

URL: Article

DOI: 10.1039/D3TC02478D

Language: English

Publisher: Royal Society of Chemistry (RSC)

Publication Date: 2023

detail.hit.zdb_id: 2702245-6

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Rocksalt CeO epitaxial thin film as a heavy-fermion system transiting from p -type metal to partially compensated n -type metal by 4 f delocalization

Abe, Nobuto ; Oka, Daichi ; Kaminaga, Kenichi ; [et al.]

American Physical Society (APS) ; 2022

In: Physical Review B Vol. 106, No. 12 ( 2022-9-6)

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In: Physical Review B, American Physical Society (APS), Vol. 106, No. 12 ( 2022-9-6)

Type of Medium: Online Resource

ISSN: 2469-9950 , 2469-9969

URL: Article

DOI: 10.1103/PhysRevB.106.125106

RVK:

UA 6500.3.B

Language: English

Publisher: American Physical Society (APS)

Publication Date: 2022

detail.hit.zdb_id: 2844160-6

detail.hit.zdb_id: 209770-9

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7

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Rocksalt-type PrO epitaxial thin film as a weak ferromagnetic Kondo lattice

Shimizu, Hirokazu ; Oka, Daichi ; Kaminaga, Kenichi ; [et al.]

American Physical Society (APS) ; 2022

In: Physical Review B Vol. 105, No. 1 ( 2022-1-31)

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In: Physical Review B, American Physical Society (APS), Vol. 105, No. 1 ( 2022-1-31)

Type of Medium: Online Resource

ISSN: 2469-9950 , 2469-9969

URL: Article

DOI: 10.1103/PhysRevB.105.014442

RVK:

UA 6500.3.B

Language: English

Publisher: American Physical Society (APS)

Publication Date: 2022

detail.hit.zdb_id: 2844160-6

detail.hit.zdb_id: 209770-9

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High electron mobility with significant spin-orbit coupling in rock-salt YbO epitaxial thin film

Yamamoto, Taku ; Kaminaga, Kenichi ; Saito, Daichi ; [et al.]

AIP Publishing ; 2019

In: Applied Physics Letters Vol. 114, No. 16 ( 2019-04-22)

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In: Applied Physics Letters, AIP Publishing, Vol. 114, No. 16 ( 2019-04-22)

Abstract: We studied the optical and electrical properties of ytterbium monoxide (YbO) epitaxial thin films with unusual Yb2+ (4f145d0) valence grown by the pulsed laser deposition method. The narrow bandgap of 0.25 eV and the large crystal field splitting of 5d orbitals in YbO determined from absorption spectra were consistent with the chemical trends of ytterbium monochalcogenides (YbChs). Electrical resistivity was tunable upon electron doping via introduction of oxygen vacancies. Electron mobility at room temperature increased up to ∼13 cm2 V−1 s−1 with increasing electron carrier density. The heavily electron-doped YbO showed weak antilocalization at low temperature, suggesting significant spin-orbit coupling owing to the heavy Yb nucleus.

Type of Medium: Online Resource

ISSN: 0003-6951 , 1077-3118

URL: Article

DOI: 10.1063/1.5085938

RVK:

UA 1000

Language: English

Publisher: AIP Publishing

Publication Date: 2019

detail.hit.zdb_id: 211245-0

detail.hit.zdb_id: 1469436-0

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Rock salt structure GdO epitaxial thin film with a high ferromagnetic Curie temperature

Yamamoto, Taku ; Kaminaga, Kenichi ; Saito, Daichi ; [et al.]

AIP Publishing ; 2020

In: Applied Physics Letters Vol. 117, No. 5 ( 2020-08-03)

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In: Applied Physics Letters, AIP Publishing, Vol. 117, No. 5 ( 2020-08-03)

Abstract: GdO with unusual valence of Gd2+ (4f75d1) has been known as the only gas phase so far. In this study, we report on the growth of solid phase rock salt structure GdO epitaxial thin films. The GdO thin film was an n-type semiconductor with the bandgap of 0.1 eV. The ferromagnetic Curie temperature (TC) was as high as 276 K, which was much higher than that of archetypal ferromagnetic rare earth monoxide EuO (TC = 69 K). TC increased slightly with electron doping similar to non-stoichiometric EuO1−δ, while decreased significantly with La doping probably caused by the magnetic dilution effect due to substitution of Gd with divalent La.

Type of Medium: Online Resource

ISSN: 0003-6951 , 1077-3118

URL: Article

DOI: 10.1063/5.0017954

RVK:

UA 1000

Language: English

Publisher: AIP Publishing

Publication Date: 2020

detail.hit.zdb_id: 211245-0

detail.hit.zdb_id: 1469436-0

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Itinerant ferromagnetism in rocksalt NdO epitaxial thin films

Saito, Daichi ; Kaminaga, Kenichi ; Oka, Daichi ; [et al.]

American Physical Society (APS) ; 2019

In: Physical Review Materials Vol. 3, No. 6 ( 2019-6-13)

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In: Physical Review Materials, American Physical Society (APS), Vol. 3, No. 6 ( 2019-6-13)

Type of Medium: Online Resource

ISSN: 2475-9953

URL: Article

DOI: 10.1103/PhysRevMaterials.3.064407

Language: English

Publisher: American Physical Society (APS)

Publication Date: 2019

detail.hit.zdb_id: 2898355-5

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Kooperativer Bibliotheksverbund

Berlin Brandenburg