In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 28, No. 9 ( 2013-09), p. 1526-1531
Abstract:
Liver cirrhosis ( LC ) is accompanied by hepatic arterializations, intrahepatic shunts, and hyperdynamic circulations. These changes shorten the arrival time ( AT ) of ultrasound contrast agents to the hepatic vein ( HV ). Whether treatment of gastric fundal varices ( GV s) by balloon‐occluded transvenous obliteration ( B ‐ RTO ) improves the AT in LC patients was prospectively investigated. Methods A total of 32 LC patients with GV s and 10 normal controls ( NC s) were enrolled. This study was approved by the clinical research ethics committee. Images of hepatic artery ( HA ), portal vein ( PV ), and HV were monitored after an injection of a contrast agent using quantification software. The AT before and after B ‐ RTO in LC patients and that in NC s were compared. Results All GV s were treated effectively, and indocyanine green retention rate was improved ( P 〈 0.0001). The mean values of the HA , PV , and HV AT s in the NC s were 21.9 ± 3.3, 28.2 ± 2.0, and 40.5 ± 2.1 s, respectively. Those in LC patients were 17.4 ± 4.4, 21.9 ± 5.6, and 26.3 ± 6.7, respectively, which were shorter than those in NC s ( P 〈 0.01, P 〈 0.002, P 〈 0.0001, respectively). However, these AT s were significantly prolonged 1 week after B ‐ RTO , with mean values of 18.7 ± 4.8, 23.8 ± 6.0, and 30.0 ± 7.2 s ( P = 0.043, P 〈 0.01, P 〈 0.001). Conclusion Obliteration of GV s shifted the AT in LC patients to the normalization, raising the possibility of improvement of arterialization and intrahepatic shunt.
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1111/jgh.2013.28.issue-9
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2006782-3
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