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  • 1
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    Systems biology under heat stress in Indian cattle
    Elsevier BV ; 2021
    In:  Gene Vol. 805 ( 2021-12), p. 145908-
    Details
    In: Gene, Elsevier BV, Vol. 805 ( 2021-12), p. 145908-
    Type of Medium: Online Resource
    ISSN: 0378-1119
    URL: Article
    DOI: 10.1016/j.gene.2021.145908
    RVK:
    WA 15000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1491012-3
    SSG: 12
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  • 2
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    Abstract 17153: Trends in Coronary Revascularization Among Cancer Patients in the United States, 2005-2014
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Circulation Vol. 138, No. Suppl_1 ( 2018-11-06)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 138, No. Suppl_1 ( 2018-11-06)
    Abstract: Introduction: Although co-existing coronary artery disease (CAD) and cancers are increasing, trends of coronary revascularization in patients with cancer history is scarce. Hence, we examined trends, costs, hospital length of stay and in-hospital mortality among cancer patients who underwent percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) surgery in the United States. Methods: The current study was a retrospective analysis of the National Inpatient Sample, collected during the period 2005-2014. Coronary revascularizations were identified among patients ≥45 years by procedure codes 36.01-36.07, 36.09, or 00.66 for PCI, and 36.1x for CABG surgery. Cancer hospitalizations were identified if any of the CCS codes were 11-43. Results: A total of 8,428,811 weighted coronary revascularizations were done during the study period, and 636,819 (7.6%) were among cancer patients. Of this, 454,138 (71.3%) were PCI and 182,681 (28.7%) were CABG. About 35.0% were in the age group 65-74 years and 41.0% in the age group ≥70 years. Majority of patients had Medicare coverage (72.0%), followed by private insurance (22.15%). Among patients with history of cancer, coronary revascularizations increased significantly from 6.5% to 8.5% (relative increase, 30.8%; P trend 〈 0.001). PCI increased significantly from 4.7% to 6.0% (relative increase, 27.7%; P trend 〈 0.001) and CABG increased significantly from 1.8% to 2.5% (relative increase, 38.9%; P trend =0.056) during the study period. The median (interquartile range [IQR]) length of stay decreased significantly from 2.8 (0.86-6.3) to 3.2 (1.6-6.4) days (relative decrease, 14.3%; P trend =0.003) and overall in-hospital mortality rate increased significantly from 1.7% to 2.4% (relative decrease, 41.2%; P trend =0.031). Median cost of hospitalizations increased significantly from $51,206 to $87,935 (relative increase, 71.7%; P trend =0.047). Conclusion: Cancer patients had increasing number of coronary revascularization interventions and adverse hospital outcomes. Prevention and management of risk factors, early disease diagnosis, and advanced treatments should be implemented to improve CAD outcomes in this population.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.138.suppl_1.17153
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 1466401-X
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  • 3
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    Abstract P338: Cardiovascular And Cerebrovascular Events Associated With Cancer Surgery In The United States
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Circulation Vol. 141, No. Suppl_1 ( 2020-03-03)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 141, No. Suppl_1 ( 2020-03-03)
    Abstract: Background: Major adverse cardiovascular and cerebrovascular events (MACCE) are significant causes of perioperative morbidity and mortality but, the incidence and effects following cancer surgeries are unknown. The aims of this study were to evaluate national trends in MACCE after major cancer surgeries and to identify cancer types associated with cardiovascular events using a large national database. Methods: Patients who had major cancer surgeries from 2005 to 2014 were identified from the National Inpatient Sample database. Hospitalizations for surgeries for cancer of prostate, bladder, esophagus, pancreas, lung, liver, breast, colon and rectum were identified by ICD9 diagnosis and procedure codes. The main outcome was perioperative MACCE, defined as in-hospital, all-cause death, acute myocardial infarction (AMI), or acute ischemic stroke, and was evaluated over time. Results: Among 2,854,810 hospitalizations for major cancer surgeries, perioperative MACCE occurred in 67,316 hospitalizations (2.4%). Mean (SE) age of patients was 65.4 (0.07) years and 54.2% were male patients. MACCE occurred most frequently in patients undergoing surgeries for lung (6.8%), pancreatic (4.5%), and colorectal (3.3%) cancers. Between 2005 and 2014, the frequency of MACCE declined from 2.7% to 2.2% ( P 〈 0.001) and was driven by a decline in the frequency of perioperative death ( P 〈 0.001) and AMI ( P = 0.002). However, no significant changes were observed for acute ischemic stroke ( P = 0.6) during the study period. Conclusion: Perioperative MACCE occurs in 1 out of every 42 hospitalizations for major cancer surgeries. Despite reductions in the rate of death and AMI among patients undergoing major cardiac surgeries, perioperative ischemic stroke remained constant over time. The lack of improvements in perioperative ischemic stroke rate is concerning and requires additional interventions. Significant efforts should be directed towards improving cardiovascular care during the perioperative period of cancer surgeries.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.141.suppl_1.P338
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 1466401-X
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  • 4
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    Abstract 013: Racial Disparities in Maternal Hypertension and Pregnancy Outcomes a Population-Based Study
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Hypertension Vol. 74, No. Suppl_1 ( 2019-09)
    Details
    In: Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 74, No. Suppl_1 ( 2019-09)
    Abstract: Objective: Maternal pre-pregnancy hypertension is an established risk factor for preterm births and infant deaths. We sought to investigate the effects of maternal pre-pregnancy hypertension and tobacco use on preterm and infant deaths. Methods: We analyzed National Vital Statistics System’s 2013 and 2015 linked birth/ infant death data from a total sample of 6,629,652 live births. There were 11,782 preterm deaths due to “Newborn affected by maternal factors and by complications.” Maternal factors and complications were defined as deaths at less than 1 year of age with ICD-10 codes P00-P04. Regression model was accounted for tobacco use, cigarette use before and during pregnancy, prenatal care, maternal age and demographics. Results: Disease specific preterm mortality due to pre-pregnancy hypertension was 1.9 per/1000 live births. Preterm risk increased by two folds (adjusted odds ratio (AOR)=2.12; 95% confidence interval (CI) 1.92-2.18) with maternal pre-pregnancy hypertension history. Presence of pre-pregnancy hypertension and tobacco use doubled the risk of preterm (AOR=3.82 (95% CI: 3.67-4.82). African American mothers with pre-pregnancy hypertension were 1.72 time more likely to have preterm mortality than White females. Conclusion: Black race, maternal risk factor pre-pregnancy hypertension and tobacco use during pregnancy were associated with higher risk of preterm mortality. Further investigation is crucial to better understand the risk factors for the disparities in preterm so that women who are at risk pre-pregnancy can be identified and provided risk-specific services.
    Type of Medium: Online Resource
    ISSN: 0194-911X , 1524-4563
    URL: Article
    DOI: 10.1161/hyp.74.suppl_1.013
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2094210-2
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  • 5
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    Abstract 11698: Family History of Atherosclerotic Cardiovascular Disease and Subclinical Coronary Atherosclerosis Among Asymptomatic Individuals: The Miami Heart Study at Baptist Health South Florida
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Circulation Vol. 146, No. Suppl_1 ( 2022-11-08)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
    Abstract: Introduction: We sought to examine whether a positive family history of coronary heart disease and/or stroke (FamHx) is associated with presence of subclinical coronary atherosclerosis, as evaluated using CAC and CCTA, in asymptomatic individuals. We also evaluated whether these associations differ by FamHx type. Hypothesis: Coronary atherosclerotic plaque burden by CCTA and baseline CAC score will differ depending on the FamHx domain assessed. Methods: We included 2,359 asymptomatic participants free from known ASCVD from the Miami Heart Study, an ongoing, community-based, prospective cohort study where all participants underwent CAC, CCTA, and FHx assessment at baseline. Self-reported FamHx in first-degree relatives was evaluated using 5 definitions: any, premature, parental, sibling, and both parents and siblings. We used multivariable logistic regression models to estimate adjusted the associations between each FamHx definition, CAC 〉 0, and presence of any coronary plaque on CCTA. Results: A total of 546 (23%) participants reported any FamHx (mean age 53.5 +/- 6.8 years, 54% female, 45% with CAC 〉 0, and 50% with any coronary plaque). In analyses adjusted for sociodemographics, any FamHx was associated with CAC 〉 0, and FamHx of both parents and siblings showed the strongest association with CAC 〉 0 (OR 2.17; 95% CI 1.01, 4.67), followed by premature FamHx ( Table ). The associations for any and parental FamHx remained statistically significant after further adjusting for traditional risk factors, while the other definitions trended in the same direction, but the confidence intervals included the null value. Associations with any plaque on CCTA were weaker than for CAC 〉 0, and none was statistically significant. Conclusion: FamHx, particularly a FamHx in both parents and siblings and premature FamHx, is associated with presence of CAC 〉 0. The number of participants with several definitions of FHx was low, likely limiting statistical power.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.146.suppl_1.11698
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1466401-X
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  • 6
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    Survival outcomes of sarcomatoid versus classic urothelial carcinoma of bladder.
    American Society of Clinical Oncology (ASCO) ; 2023
    In:  Journal of Clinical Oncology Vol. 41, No. 16_suppl ( 2023-06-01), p. 4588-4588
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 41, No. 16_suppl ( 2023-06-01), p. 4588-4588
    Abstract: 4588 Background: Sarcomatoid urothelial carcinoma (SUC), a rare bladder cancer variant, has both epithelial and mesenchymal differentiation along with frequent TERT C228T promoter mutations and has poorer prognosis. In this study, we compared survival outcomes of SUC with classic urothelial carcinoma (CUC) in patients with T2-T4, N0-N1 bladder cancer after definitive therapy. Methods: All cases meeting our inclusion criteria for SUC and CUC during 2004-2019 were identified from National Cancer Database. Sociodemographic and clinicopathological characteristics were analyzed via descriptive and comparative statistics. Propensity-score matching was performed to adjust for baseline differences between SUC and CUC. Overall survival (OS) was compared using Cox proportional-hazards modelling and visualized through Kaplan-Meier curves. Results: 30072 cases of CUC and 480 of SUC were identified. Propensity-score matching resulted in N = 478 patients in both groups. Matched cohorts had no baseline differences in age, sex, race, comorbidities, insurance status, income, distance to hospital, hospital location, rural versus urban residence, histological grade, and proportion getting regional lymph node surgery. Overall, there were 675 males and 281 females, 435 underwent surgery (Sx), and 521 surgery plus chemotherapy (Sx+Cx). For SUC, median survival with Sx vs Sx+Cx was 29.5 months (95%CI 20.0-50.6) vs 43.1 months (95%CI 25.3-64.4) respectively. For CUC, median survival was 56.1 (95%CI 53.7-58.6) vs 78.0 (95%CI 75.1-81.1) months with Sx vs Sx+Cx respectively. Conclusions: SUC has poorer prognosis than CUC. Perioperative chemotherapy along with surgery was associated with improved survival outcomes compared to surgery alone in patients with SUC. Further studies investigating novel immunotherapy agents are warranted to improve oncologic outcomes. [Table: see text]
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2023.41.16_suppl.4588
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2023
    detail.hit.zdb_id: 2005181-5
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  • 7
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    Lumican, pro-tumorigenic or anti-tumorigenic: A conundrum
    Elsevier BV ; 2021
    In:  Clinica Chimica Acta Vol. 514 ( 2021-03), p. 1-7
    Details
    In: Clinica Chimica Acta, Elsevier BV, Vol. 514 ( 2021-03), p. 1-7
    Type of Medium: Online Resource
    ISSN: 0009-8981
    URL: Article
    DOI: 10.1016/j.cca.2020.12.011
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1499920-1
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  • 8
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    Insulin Resistance Shows Stronger Correlation With Ectopic Liver Fat Instead of Visceral Fat in Asian Indians
    The Endocrine Society ; 2021
    In:  Journal of the Endocrine Society Vol. 5, No. Supplement_1 ( 2021-05-03), p. A18-A18
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 5, No. Supplement_1 ( 2021-05-03), p. A18-A18
    Abstract: Introduction: Insulin resistance (IR) is associated with abdominal obesity. Asian Indians have higher insulin resistance at lower abdominal obesity levels as compared to the western population. However, the relative association of various compartments of abdominal fat, i.e., Subcutaneous Fat (SCAT), Visceral fat (VAT), and ectopic Liver Fat, is not very clear. Our study’s objective was to look for the association of abdominal fat composition in Asian Indians with IR level and gender and diabetes status. Methodology: Our study is an analytical cross-sectional study conducted from 2018–2020 at SMS Hospital located in northwest India. 91 subjects were studied during the study period and underwent MRI for SCAT, VAT, and Liver fat estimation. We divided subjects into tertile groups, based on HOMA-IR levels, and statistical analysis for SCAT, VAT, and Lipid fat in each tertile and as a whole group carried out. Similarly, we analysed data in male and female and diabetic and non-diabetic groups, as tertiles and as a whole. Results: Of the recruited subjects 49 were diabetics (M: F=23:26) and 42 were non-diabetic (M: F=12:30). In the overall group, HOMA-IR has a weak positive association with VAT and Liver Fat and a weak negative association with SCAT (R=0.28,0.38 and -0.11, respectively). From tertile1 to tertile3, there was a consistent increase in VAT and Liver fat (119.3, 121.1, 156.6 cm2 and 8.18, 10.02, 10.89% respectively), so that R value increases from -0.24 to 0.21 for VAT and -0.195 to 0.58 for Liver Fat. On the other hand, the SCAT levels were not different and correlation with IR declined from -0.299 to -0.39. On Sex wise analysis negative correlation of SCAT with IR become substantial from tertile1 to tertile3 in both males and females but strong correlation was seen in females (-0.189 to -0.515) though amount of SCAT was not different among tertiles. Both VAT and Liver Fat increased with tertile1 to terrtile3; IR was very strongly correlated with Liver Fat in both the sexes at higher tertiles (0.91 for males and 0.71 for females). In the diabetic group, liver fat was significantly associated with IR at higher tertile (R=0.9). The SCAT was negatively associated with IR, and a further decline in correlation coefficient with each tertile, became significant at 3rd tertile (-0.41) with a weak correlation of IR with VAT. These relations have similar SCAT and Liver fat trends but a strong correlation not seen in the non-diabetic group. Conclusion: Insulin resistance strongly correlated with ectopic liver fat in Asian Indians including diabetics with no gender disparity which became significant at higher tertile. As compared to ectopic liver fat, VAT has only a minor role in development of IR. SCAT has a protective role against IR in both diabetics and non-diabetics.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvab048.033
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2021
    detail.hit.zdb_id: 2881023-5
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  • 9
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    In‐hospital outcomes of transesophageal versus intracardiac echocardiography guided left atrial appendage closure
    Wiley ; 2022
    In:  Catheterization and Cardiovascular Interventions Vol. 99, No. 5 ( 2022-04), p. 1572-1581
    Details
    In: Catheterization and Cardiovascular Interventions, Wiley, Vol. 99, No. 5 ( 2022-04), p. 1572-1581
    Abstract: Transesophageal echocardiogram (TEE) is the preferred imaging modality to guide transcatheter left atrial appendage closure (LAAC). Intracardiac echocardiography (ICE) has evolved as a less invasive alternative to TEE. Several observational studies have shown similar success rates and perioperative complications between TEE and ICE for LAAC. Objectives We sought to examine the temporal trends and patient characteristics of TEE versus ICE use in LAAC using a national database. We also evaluated hospital outcomes including periprocedural complications, mortality, and length of hospital stay. Methods This is a retrospective analysis of data from the National Readmission Database, collected from 2016 to 2018. The primary outcome was major adverse events (MAE) defined as in‐hospital mortality, cardiac arrest, pericardial effusion with or without tamponade, pericardiocentesis or window pericardiocentesis and pericardial window, pericardial effusion and tamponade, and hemorrhage requiring transfusion. Results Trend analysis showed that TEE‐guided LAAC increased from 96.6% in 2016 to 98.4% in 2018 (relative increase, 1.9%), while ICE‐guided LAAC decreased from 3.4% to 1.6% during the same period (relative decrease, 53%, p for trend = 0.08). In the unmatched cohorts, the MAE was significantly lower in TEE‐guided LAAC compared to ICE‐guided LAAC (6.5% vs. 9.3%, p  = 0.022). In the propensity score matching analysis, MAE remained significant (5.6% vs. 9.4%, p   〈  0.001). The incidence of pericardial effusion with or without tamponade remained significantly lower in the TEE group (2.3% vs. 5.8%, p   〈  0.001). Length of stay (3.4 vs. 1.9 days, p   〈  0.001) and hospitalization cost ($34,826 vs. $20,563, p   〈  0.001) remained significantly lower for TEE‐guided LAAC. Conclusions Compared to ICE, the incidence of MAE was significantly lower for TEE‐guided LAAC, driven mainly by less pericardial effusion events. Large‐scale randomized trials are needed to confirm the findings of the current and previous studies.
    Type of Medium: Online Resource
    ISSN: 1522-1946 , 1522-726X
    URL: Issue
    URL: Article
    DOI: 10.1002/ccd.v99.5
    DOI: 10.1002/ccd.30086
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001555-0
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  • 10
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    Lipid Metabolite Biomarkers in Cardiovascular Disease: Discovery and Biomechanism Translation from Human Studies
    MDPI AG ; 2021
    In:  Metabolites Vol. 11, No. 9 ( 2021-09-14), p. 621-
    Details
    In: Metabolites, MDPI AG, Vol. 11, No. 9 ( 2021-09-14), p. 621-
    Abstract: Lipids represent a valuable target for metabolomic studies since altered lipid metabolism is known to drive the pathological changes in cardiovascular disease (CVD). Metabolomic technologies give us the ability to measure thousands of metabolites providing us with a metabolic fingerprint of individual patients. Metabolomic studies in humans have supported previous findings into the pathomechanisms of CVD, namely atherosclerosis, apoptosis, inflammation, oxidative stress, and insulin resistance. The most widely studied classes of lipid metabolite biomarkers in CVD are phospholipids, sphingolipids/ceramides, glycolipids, cholesterol esters, fatty acids, and acylcarnitines. Technological advancements have enabled novel strategies to discover individual biomarkers or panels that may aid in the diagnosis and prognosis of CVD, with sphingolipids/ceramides as the most promising class of biomarkers thus far. In this review, application of metabolomic profiling for biomarker discovery to aid in the diagnosis and prognosis of CVD as well as metabolic abnormalities in CVD will be discussed with particular emphasis on lipid metabolites.
    Type of Medium: Online Resource
    ISSN: 2218-1989
    URL: Article
    DOI: 10.3390/metabo11090621
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2662251-8
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