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Weekday-dependent long-term outcomes in gastrointestinal cancer surgery: a german population-based retrospective cohort study

Maier, Christopher Fabian ; Schölch, Caroline ; Zhu, Lei ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2023

In: International Journal of Surgery

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In: International Journal of Surgery, Ovid Technologies (Wolters Kluwer Health)

Abstract: For most solid cancers, surgery represents the mainstay of curative treatment. Several studies investigating the effects of the weekday of surgery (WOS) on patient outcomes have yielded conflicting results. Barmer, the second-largest health insurance company in Germany, serves roughly 10% of the German population. We have used the Barmer database to evaluate how the weekday on which the surgery is performed influences long-term oncologic outcomes. Methods: For this retrospective cohort study, the Barmer database was used to investigate the effect of the WOS (Monday–Friday) on outcomes following oncological resections of the colorectum (n=49,003), liver (n=1,302), stomach (n=5027), esophagus (n=1126), and pancreas (n=6,097). In total, 62,555 cases from 2008 to 2018 were included in the analysis. The endpoints were overall survival (OS), postoperative complications, and necessity for therapeutic interventions or re-operations. We furthermore examined whether the annual caseload or certification as a cancer center influenced the weekday effect. Results: We observed a significantly impaired OS for patients receiving gastric or colorectal resections on a Monday. Colorectal surgery performed on Mondays was associated with more postoperative complications and higher probability of re-operations. The annual caseload or a certification as a colorectal cancer center had no bearing on the observed weekday effect. There is evidence that hospitals schedule older patients with more comorbidities earlier in the week, possibly explaining these findings. Conclusion: This is the first study investigating the influence of the WOS on long-term survival in Germany. Our findings indicate that, in the German healthcare system, patients undergoing colorectal cancer surgery on Mondays have more postoperative complications and, therefore, require significantly more re-operations, ultimately lowering OS. This surprising finding appears to reflect an attempt to schedule patients with higher postoperative risk earlier in the week as well as semi-elective patients admitted on weekends scheduled for surgery on the next Monday.

Type of Medium: Online Resource

ISSN: 1743-9191

URL: Article

DOI: 10.1097/JS9.0000000000000580

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2023

detail.hit.zdb_id: 2201966-2

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Wissenschaftspark Albert Einstein

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TH Wildau

FH Potsdam

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Porcine uterus cryopreservation: An analysis of contractile function using different uterotonics

Schölch, Daniel ; Schölch, Sebastian ; Strahl, Olga ; [et al.]

Elsevier BV ; 2012

In: Cryobiology Vol. 65, No. 2 ( 2012-10), p. 88-92

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In: Cryobiology, Elsevier BV, Vol. 65, No. 2 ( 2012-10), p. 88-92

Type of Medium: Online Resource

ISSN: 0011-2240

URL: Article

DOI: 10.1016/j.cryobiol.2012.05.009

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1463192-1

detail.hit.zdb_id: 80098-3

SSG: 12

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Prognostic value of DLGAP5 in colorectal cancer

Branchi, Vittorio ; García, Sebastián A. ; Radhakrishnan, Praveen ; [et al.]

Springer Science and Business Media LLC ; 2019

In: International Journal of Colorectal Disease Vol. 34, No. 8 ( 2019-8), p. 1455-1465

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In: International Journal of Colorectal Disease, Springer Science and Business Media LLC, Vol. 34, No. 8 ( 2019-8), p. 1455-1465

Type of Medium: Online Resource

ISSN: 0179-1958 , 1432-1262

URL: Article

DOI: 10.1007/s00384-019-03339-6

RVK:

XA 50991

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 1459217-4

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TH Wildau

FH Potsdam

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Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer

Kochall, Susan ; Thepkaysone, May-Linn ; García, Sebastián A. ; [et al.]

MyJove Corporation ; 2017

In: Journal of Visualized Experiments , No. 125 ( 2017-07-18)

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In: Journal of Visualized Experiments, MyJove Corporation, , No. 125 ( 2017-07-18)

Type of Medium: Online Resource

ISSN: 1940-087X

URL: Article

DOI: 10.3791/55357-v

Language: English

Publisher: MyJove Corporation

Publication Date: 2017

detail.hit.zdb_id: 2259946-0

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Community-driven development of a modified progression-free survival ratio for precision oncology

Mock, Andreas ; Heilig, Christoph E ; Kreutzfeldt, Simon ; [et al.]

Elsevier BV ; 2019

In: ESMO Open Vol. 4, No. 6 ( 2019), p. e000583-

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In: ESMO Open, Elsevier BV, Vol. 4, No. 6 ( 2019), p. e000583-

Type of Medium: Online Resource

ISSN: 2059-7029

URL: Article

DOI: 10.1136/esmoopen-2019-000583

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 2844985-X

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TH Wildau

FH Potsdam

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Circulating tumor cells exhibit stem cell characteristics in an orthotopic mouse model of colorectal cancer

Schölch, Sebastian ; García, Sebastián A. ; Iwata, Naoki ; [et al.]

Impact Journals, LLC ; 2016

In: Oncotarget Vol. 7, No. 19 ( 2016-05-10), p. 27232-27242

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In: Oncotarget, Impact Journals, LLC, Vol. 7, No. 19 ( 2016-05-10), p. 27232-27242

Type of Medium: Online Resource

ISSN: 1949-2553

URL: Issue

URL: Article

DOI: 10.18632/oncotarget.v7i19

DOI: 10.18632/oncotarget.8373

Language: English

Publisher: Impact Journals, LLC

Publication Date: 2016

detail.hit.zdb_id: 2560162-3

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BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

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A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Betzler, Alexander M. ; Kochall, Susan ; Blickensdörfer, Linda ; [et al.]

MyJove Corporation ; 2017

In: Journal of Visualized Experiments , No. 125 ( 2017-07-06)

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In: Journal of Visualized Experiments, MyJove Corporation, , No. 125 ( 2017-07-06)

Type of Medium: Online Resource

ISSN: 1940-087X

URL: Article

DOI: 10.3791/55952-v

Language: English

Publisher: MyJove Corporation

Publication Date: 2017

detail.hit.zdb_id: 2259946-0

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Wissenschaftspark Albert Einstein

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TH Wildau

FH Potsdam

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Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice

Elßner, Christin ; Goeppert, Benjamin ; Longerich, Thomas ; [et al.]

Elsevier BV ; 2019

In: Gastroenterology Vol. 156, No. 4 ( 2019-03), p. 1190-1205.e14

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In: Gastroenterology, Elsevier BV, Vol. 156, No. 4 ( 2019-03), p. 1190-1205.e14

Type of Medium: Online Resource

ISSN: 0016-5085

URL: Article

DOI: 10.1053/j.gastro.2018.11.018

RVK:

XA 44500

Language: English

Publisher: Elsevier BV

Publication Date: 2019

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Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations

Seidlitz, Therese ; Chen, Yi-Ting ; Uhlemann, Heike ; [et al.]

Elsevier BV ; 2019

In: Gastroenterology Vol. 157, No. 6 ( 2019-12), p. 1599-1614.e2

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In: Gastroenterology, Elsevier BV, Vol. 157, No. 6 ( 2019-12), p. 1599-1614.e2

Type of Medium: Online Resource

ISSN: 0016-5085

URL: Article

DOI: 10.1053/j.gastro.2019.09.026

RVK:

XA 44500

Language: English

Publisher: Elsevier BV

Publication Date: 2019

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Human gastric cancer modelling using organoids

Seidlitz, Therese ; Merker, Sebastian R ; Rothe, Alexander ; [et al.]

BMJ ; 2019

In: Gut Vol. 68, No. 2 ( 2019-02), p. 207-217

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In: Gut, BMJ, Vol. 68, No. 2 ( 2019-02), p. 207-217

Abstract: Gastric cancer is the second leading cause of cancer-related deaths and the fifth most common malignancy worldwide. In this study, human and mouse gastric cancer organoids were generated to model the disease and perform drug testing to delineate treatment strategies. Design Human gastric cancer organoid cultures were established, samples classified according to their molecular profile and their response to conventional chemotherapeutics tested. Targeted treatment was performed according to specific druggable mutations. Mouse gastric cancer organoid cultures were generated carrying molecular subtype-specific alterations. Results Twenty human gastric cancer organoid cultures were established and four selected for a comprehensive in-depth analysis. Organoids demonstrated divergent growth characteristics and morphologies. Immunohistochemistry showed similar characteristics to the corresponding primary tissue. A divergent response to 5-fluoruracil, oxaliplatin, irinotecan, epirubicin and docetaxel treatment was observed. Whole genome sequencing revealed a mutational spectrum that corresponded to the previously identified microsatellite instable, genomic stable and chromosomal instable subtypes of gastric cancer. The mutational landscape allowed targeted therapy with trastuzumab for ERBB2 alterations and palbociclib for CDKN2A loss. Mouse cancer organoids carrying Kras and Tp53 or Apc and Cdh1 mutations were characterised and serve as model system to study the signalling of induced pathways. Conclusion We generated human and mouse gastric cancer organoids modelling typical characteristics and altered pathways of human gastric cancer. Successful interference with activated pathways demonstrates their potential usefulness as living biomarkers for therapy response testing.

Type of Medium: Online Resource

ISSN: 0017-5749 , 1468-3288

URL: Article

DOI: 10.1136/gutjnl-2017-314549

DOI: 10.1136/gutjnl-2017-314549.supp8

DOI: 10.1136/gutjnl-2017-314549.supp12

DOI: 10.1136/gutjnl-2017-314549.supp1

DOI: 10.1136/gutjnl-2017-314549.supp3

DOI: 10.1136/gutjnl-2017-314549.supp4

DOI: 10.1136/gutjnl-2017-314549.supp9

DOI: 10.1136/gutjnl-2017-314549.supp10

DOI: 10.1136/gutjnl-2017-314549.supp5

DOI: 10.1136/gutjnl-2017-314549.supp6

DOI: 10.1136/gutjnl-2017-314549.supp11

DOI: 10.1136/gutjnl-2017-314549.supp7

DOI: 10.1136/gutjnl-2017-314549.supp2

DOI: 10.1136/gutjnl-2017-314549.supp13

RVK:

XA 10000

Language: English

Publisher: BMJ

Publication Date: 2019

detail.hit.zdb_id: 1492637-4

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